Long-term high-protein diet induces biochemical and ultrastructural changes in rat liver mitochondria

Jordá, A.; Zaragozá, Remedios; Portolés, Manuel; Báguena-Cervellera, R.; Renau‐Piqueras, Jaime

doi:10.1016/0003-9861(88)90124-5

Cited by 16 publications

(7 citation statements)

References 12 publications

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“…Nevertheless, based on the evidence reviewed above, the weight loss observed while on not in a high-protein diet also could be a direct result of the increased water intake. Furthermore, an increased protein diet is also associated with an increase in size and number of functionally normal liver cell mitochondria ( 122 , 123 ). This would correlate with an increase in cell size following an increase in hydration as mentioned above.…”

Section: Diets Drinking and Weight Lossmentioning

confidence: 99%

Increased Hydration Can Be Associated with Weight Loss

Thornton

2016

Front. Nutr.

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This mini-review develops the hypothesis that increased hydration leads to body weight loss, mainly through a decrease in feeding, and a loss of fat, through increased lipolysis. The publications cited come from animal, mainly rodent, studies where manipulations of the central and/or the peripheral renin–angiotensin system lead to an increased drinking response and a decrease in body weight. This hypothesis derives from a broader association between chronic hypohydration (extracellular dehydration) and raised levels of the hormone angiotensin II (AngII) associated with many chronic diseases, such as obesity, diabetes, cancer, and cardiovascular disease. Proposed mechanisms to explain these effects involve an increase in metabolism due to hydration expanding cell volume. The results of these animal studies often can be applied to the humans. Human studies are consistent with this hypothesis for weight loss and for reducing the risk factors in the development of obesity and type 2 diabetes.

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Section: Diets Drinking and Weight Lossmentioning

confidence: 99%

Increased Hydration Can Be Associated with Weight Loss

Thornton

2016

Front. Nutr.

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“…Sympathetic activation [99] and increases in metabolic rate [87] were detected following water intake in humans. Secondly, animal studies showed that higher protein concentrations in experimental diets significantly enhanced water intake in mice [100], rats [101–103], and pigs [94] accompanied by higher urine volumes. Interestingly, mice fed high-protein diets exhibited higher liver water contents [91].…”

Section: Metabolic Consequences Of Increased Water Intake In Responsementioning

confidence: 99%

Beyond the Role of Dietary Protein and Amino Acids in the Prevention of Diet-Induced Obesity

Petzke

Freudenberg

Klaus

2014

IJMS

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High-protein diets have been shown to prevent the development of diet-induced obesity and can improve associated metabolic disorders in mice. Dietary leucine supplementation can partially mimic this effect. However, the molecular mechanisms triggering these preventive effects remain to be satisfactorily explained. Here we review studies showing a connection between high protein or total amino nitrogen intake and obligatory water intake. High amino nitrogen intake may possibly lower lipid storage, and prevent insulin resistance. Suggestions are made for further systematical studies to explore the relationship between water consumption, satiety, and energy expenditure. Moreover, these examinations should better distinguish between leucine-specific and unspecific effects. Research in this field can provide important information to justify dietary recommendations and strategies in promoting long-term weight loss and may help to reduce health problems associated with the comorbidities of obesity.

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“…It is postulated that the increased production of free radicals is primarily a result of disorders of energy process in the mitochondrial respiratory chain [ 44 ]. In addition, it has been demonstrated that a long-term high-protein diet causes significant biochemical and ultrastructural changes in rat liver mitochondria and thus increase ROS production [ 45 ]. In our study, we found an increase of the MDA concentration in the liver of rats receiving WPC-80 at a dose of 0.5 g/kg of body weight compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Whey Protein Concentrate WPC-80 Intensifies Glycoconjugate Catabolism and Induces Oxidative Stress in the Liver of Rats

et al. 2018

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The aim of this study was to evaluate the effect of whey protein concentrate (WPC-80) on glycoconjugate catabolism, selected markers of oxidative stress and liver inflammation. The experiment was conducted on male Wistar rats (n = 63). The animals from the study group were administered WPC-80 at a dose of 0.3 or 0.5 g/kg body weight for 7, 14 or 21 days, while rats from the control group received only 0.9% NaCl. In liver homogenates, we assayed the activity of N-acetyl-β-D-hexosaminidase (HEX), β-glucuronidase (GLU), β-galactosidase (GAL), α-mannosidase (MAN), α-fucosidase (FUC), as well as the level of reduced glutathione (GSH), malondialdehyde (MDA), interleukin-1β (IL-1β) and transforming growth factor-β1 (TGF-β1). A significantly higher activity of HEX, GLU, MAN and FUC were found in the livers of rats receiving WPC-80 compared to controls. Serum ALT and AST were significantly higher in the animals supplemented with WPC-80 at a dose of 0.5 g/kg body weight for 21 days. In the same group of animals, enhanced level of GSH, MDA, IL-1β and TGF-β1 were also observed. WPC-80 is responsible for intensive remodelling of liver tissue and induction of oxidative stress especially at a dose of 0.5 g/kg body weight.

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Long-term high-protein diet induces biochemical and ultrastructural changes in rat liver mitochondria

Cited by 16 publications

References 12 publications

Increased Hydration Can Be Associated with Weight Loss

Increased Hydration Can Be Associated with Weight Loss

Beyond the Role of Dietary Protein and Amino Acids in the Prevention of Diet-Induced Obesity

Whey Protein Concentrate WPC-80 Intensifies Glycoconjugate Catabolism and Induces Oxidative Stress in the Liver of Rats

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