Long-Term Humoral and Hemodynamic Effects of Celiprolol

Ar, Lucarini; Simonini, N.; Palmieri, L; Salvetti, A.

doi:10.1093/ajh/1.3.211s

Cited by 5 publications

(2 citation statements)

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“…In this respect, not only carvedilol, but also bopindolol and celiprolol, seem to be excellent antihypertensive agents, although carvedilol was superior to the other two beta‐blockers. In support of our findings, all three beta‐blockers have been documented to maintain renal blood flow when blood pressure is decreased by treatment 15–17 18 …”

Section: Discussionsupporting

confidence: 89%

“…In support of our findings, all three beta-blockers have been documented to maintain renal blood flow when blood pressure is decreased by treatment. [15][16][17] Recently, it was found that nitric oxide could be released by celiprolol, bopindolol and nebivolol, but not by propranolol or bisoprolol, via stimulation of 5-HT1A receptors in the kidney and that it dilates the renal vasculature. 18 Another interesting finding in the present study was the effect of the beta-blockers on the blood flow in brown fat.…”

Section: Discussionmentioning

confidence: 99%

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Effect Of Vasodilatory β‐Adrenoceptor Blockers On Cardiovascular Haemodynamics In Anaesthetized Rats

Takahashi

Masaki

Komiyama

et al. 2002

Clin Exp Pharma Physio

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1. The effect of vasodilatory beta-adrenoceptor blockers on regional blood flow in the major organs of anaesthetized rats was investigated using radioactive microspheres. The administration of propranolol and saline was used as a control. 2. Intravenous injections of carvedilol (2 mg/rat), celiprolol (20 mg/rat) and bopindolol (1 mg/rat) equally decreased systemic blood pressure (SBP) by approximately 20 mmHg, whereas propranolol (1 mg/rat) decreased SBP only slightly but not significantly. 3. Heart rate was significantly decreased by carvedilol, celiprolol, bopindolol and propranolol. 4. Coronary blood flow was markedly increased by carvedilol, but not by the other three drugs. 5. Cardiac output tended to decrease following the administration of all four drugs. 6. Total peripheral vascular resistance was not significantly affected by carvedilol, celiprolol and bopindolol, but was markedly increased following propranolol. 7. Renal blood flow was markedly increased by carvedilol. 8. Blood flow in the brown fat was markedly increased by carvedilol and bopindolol, but not by celiprolol and propranolol. 9. These findings indicate that the newer vasodilatory beta-blockers, such as carvedilol and bopindolol, have a beneficial effect on the regional circulation in contrast with the classical beta-blocker propranolol. 10. The regional haemodynamic effects observed in the present study following intravenous injection of the beta-blockers may help explain the clinical experience that vasodilatory beta-blockers increase insulin sensitivity and decrease mortality in patients with congestive heart failure.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Effect Of Vasodilatory β‐Adrenoceptor Blockers On Cardiovascular Haemodynamics In Anaesthetized Rats

Takahashi

Masaki

Komiyama

et al. 2002

Clin Exp Pharma Physio

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Hemodynamic effects of celiprolol in essential hypertension

Fröhlich

Ketelhut

Kaesser

et al. 1991

The American Journal of Cardiology

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Are renal hemodynamics a key factor in the development and maintenance of arterial hypertension in humans?

Ruilope¹,

Lahera²,

Rodicio³

et al. 1994

Hypertension

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The kidney plays a key role in the control of body fluids and blood pressure. Evidence has shown that impairment of renal function can lead to the development of arterial hypertension. The regulation of renal blood flow appears to be a key element in the pathophysiology of the hypertensive process, because multiple evidence suggests the existence of a functional enhancement of renal vascular tone in this disorder. The existence of renal vasoconstriction and of an inherited defect in the regulation of renal blood flow has been proposed in the prehypertensive stage. The mechanisms responsible for this alteration include a lack of modulation of the renal vasculature to angiotensin II, increased sympathetic activity, or suppressed renal dopaminergic activity. Established hypertension is characterized by elevated renal vascular resistance, decreased renal blood flow, sustained glomerular filtration rate, and increased filtration fraction. The increase in renal vascular resistance is initially due to elevations in renal vascular tone and is reversible, whereas later it becomes irreversible because of structural changes involved in nephrosclerosis. Antihypertensive drugs are able to decrease blood pressure and to prevent the development of further renal vascular damage independently of variable effects on renal hemodynamics. (Hypertension. 1994^3 -3 -9.)Key Words • hemodynamics • glomerular filtration rate • sodium • hypertension, arterial • antihypertensive agents I t has long been known that the kidney plays a central role in the control of body fluids and blood pressure and that a derangement of renal function could lead to the development of hypertension.1 Furthermore, several theories have been proposed as to which specific hemodynamic or tubular alterations could induce an elevation of blood pressure.2 " 8 In this review, the clinical studies investigating changes in renal function accompanying the development and maintenance of essential hypertension are critically examined. The studies indicate that the common manifestation of hypertension is an increase of intrarenal vascular resistance; however, the manner in which this single alteration could trigger all the pathophysiological alterations responsible for hypertension is not completely known. Renal Hemodynamics in the Prehypertensive State in HumansThe role of the kidney in the development of essential hypertension has been examined in studies of control and experimental subjects with a family history of hypertension.9 These studies have revealed conflicting results. Bianchi et al 10 -11 found that renal blood flow and glomerular filtration rate were elevated in offspring of hypertensive parents, whereas filtration fraction remained normal. glomerular filtration rate were normal in the offspring of both normotensive and hypertensive parents; however, renal vascular resistance was increased.13 Van Hooft et al 14 reported that renal blood flow was reduced and renal vascular resistance and filtration fraction were elevated in young people at risk for hy...

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Long-Term Humoral and Hemodynamic Effects of Celiprolol

Cited by 5 publications

References 0 publications

Effect Of Vasodilatory β‐Adrenoceptor Blockers On Cardiovascular Haemodynamics In Anaesthetized Rats

Effect Of Vasodilatory β‐Adrenoceptor Blockers On Cardiovascular Haemodynamics In Anaesthetized Rats

Hemodynamic effects of celiprolol in essential hypertension

Are renal hemodynamics a key factor in the development and maintenance of arterial hypertension in humans?

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