Long-Term Impact of Capsule Endoscopy in Patients Referred for Iron-Deficiency Anemia

Abstract

Most patients referred for VCE examination to evaluate IDA were no longer anemic at 36 months of follow-up, with or without therapeutic intervention.

A prospective evaluation of iron deficiency anemia in the GI endoscopy setting: role of standard endoscopy, videocapsule endoscopy, and CT-enteroclysis

“…29 In the present study, VCE achieved a final diagnosis in 82.2% of patients; this proportion is higher than that observed in 2 recent reports that described a positive finding in 60% and 66%, respectively, of patients with IDA studied with VCE. 30,31 However, it should be underlined that the retrospective nature of both studies may explain the difference from our results. Nevertheless, the proportion of specific findings in the 2 studies was similar to ours, because arteriovenous malformation was largely the most frequent diagnosis (37% in both studies).…”

Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review

“…25 Seven of them were prospective 15,20,21,28,[33][34][35] and 17 were retrospective studies. [12][13][14][16][17][18][19][22][23][24][25][26][27][29][30][31][32] Only 2 were multicenter studies. 12,13 In all but 4 studies (in 3, not reported 18,23,27 and 1 study 31 with EndoCapsule [Olympus, Tokyo, Japan]), SBCE explorations were performed with capsule endoscopes from Given Imaging Ltd (Yoqneam, Israel).…”

“…Four publications focused exclusively on IDA patients (subset 1), 21,30,33,35 whereas in the remaining 20 articles, patients with IDA represented only a subgroup of a larger patient cohort undergoing SBCE (subset 2). [12][13][14][15][16][17][18][19][20][22][23][24][25][26][27][28][29]31,32,34 The QUADAS evaluation of the included studies is shown in Table 2. Nine QUADAS items (items 3-11) were not relevant and thus not assessed.…”

“…Based on the remaining 5 items (items 1, 2, 12-14), the studies included were of low or moderate quality. Nine studies (39%) 12,13,17,20,21,27,30,33,35 provided data on mean or median pre-SBCE hemoglobin (Hb) levels, 11 (43.5%) 12,13,[19][20][21][22]27,30,31,33,35 reported data on mean or median patient age. Where median and interquartile range were given instead of mean and standard deviation, approximation was used.…”

Review Article on Current Applications and Future Concepts of Capsule Endoscopy

“…In 1 patient, CE missed an ulcer [23] . Sheibani et al [24] evaluated the long-term impact of CE in patients referred for iron deficiency anemia. CE had a diagnostic yield of 61% and the CE-based diagnosis led to a therapeutic intervention in about 26% of patients.…”