Long‐term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study

Korndewal, Marjolein J.; Oudesluys‐Murphy, Anne Marie; Kroes, Aloys C.M.; Sande, Marianne A. B. van der; Melker, Hester E. de; Vossen, Ann C.T.M.

doi:10.1111/dmcn.13556

Cited by 70 publications

(106 citation statements)

References 27 publications

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“…It is the leading non-genetic cause of sensorineural hearing loss (SNHL) and a major cause of neurological disability. Around 10-15% of neonates with congenital CMV will be symptomatic at birth, and up to 25% of infected children have long-term impairments 6,7 .…”

Section: Cytomegalovirus (Cmv)mentioning

confidence: 99%

ISUOG Practice Guidelines: role of ultrasound in congenital infection

Khalil

Sotiriadis

Chaoui³

et al. 2020

Ultrasound in Obstet & Gyne

130

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ISUOG Practice Guidelines: role of ultrasound in congenital infection Clinical Standards Committee The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice, and high-quality teaching and research related to diagnostic imaging in women's healthcare. The ISUOG Clinical Standards Committee (CSC) has a remit to develop Practice Guidelines and Consensus Statements as educational recommendations that provide healthcare practitioners with a consensus-based approach, from experts, for diagnostic imaging. They are intended to reflect what is considered by ISUOG to be the best practice at the time at which they are issued. Although ISUOG has made every effort to ensure that Guidelines are accurate when issued, neither the Society nor any of its employees or members accepts any liability for the consequences of any inaccurate or misleading data, opinions or statements issued by the CSC. The ISUOG CSC documents are not intended to establish a legal standard of care, because interpretation of the evidence that underpins the Guidelines may be influenced by individual circumstances, local protocol and available resources. Approved Guidelines can be distributed freely with the permission of ISUOG (

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Section: Cytomegalovirus (Cmv)mentioning

confidence: 99%

ISUOG Practice Guidelines: role of ultrasound in congenital infection

Khalil

Sotiriadis

Chaoui³

et al. 2020

Ultrasound in Obstet & Gyne

130

View full text Add to dashboard Cite

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“…Detailed clinical consequences were described elsewhere 12. General practitioner files of 95% of the participating children were collected.…”

Section: Resultsmentioning

confidence: 99%

“…We have previously assessed the clinical consequences of cCMV in the Netherlands in a nationwide retrospective cohort study 12. In this article, the medical resource use during the first 6 years of life of children with cCMV and without cCMV were compared.…”

Section: Introductionmentioning

confidence: 99%

Healthcare costs attributable to congenital cytomegalovirus infection

et al. 2018

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ObjectiveCongenital cytomegalovirus infection (cCMV) can cause symptoms at birth as well as long-term impairment. This study estimates cCMV-related healthcare costs in the Netherlands in early childhood.Design, setting and patientsIn a nationwide retrospective cohort study, 156 children with cCMV were identified by testing 31 484 neonatal dried blood spots for cCMV. Use of healthcare resources in the first 6 years of life by children with cCMV and a matched cCMV-negative control group were analysed. Mean costs per child were calculated by multiplying healthcare resource use by its reference prices.ExposureChildren with cCMV were compared with cCMV-negative children.Main outcome measuresThe average total healthcare costs per child were based on the average costs for hospital admissions and consultations by healthcare providers.ResultsMean healthcare costs of children with cCMV (€6113, n=133) were higher than children without cCMV (€3570, n=274), although statistically not significant, with a mean difference of €2544 (95% CI €-451 to €5538). The costs of children with long-term impairment were two times higher in children with cCMV (€17 205) compared with children without cCMV (€8332).ConclusionsChildren with cCMV, especially those with long-term impairment and those symptomatic at birth, accrue higher healthcare costs than cCMV-negative children in the first 6 years of life, although this is not statistically significant. This economic impact is of importance in the evaluation of preventive measures against cCMV.Trial registration numberNTR3582.

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“…Congenital cytomegalovirus (cCMV) is the most common congenital infection, affecting around 0.7% of children in industrialized countries . This novel epidemiological study from the Netherlands by Korndewal et al gives us new evidence regarding the significant burden of long‐term neurodevelopmental problems in children with cCMV . The study used a consented retrospective design, testing saved newborn dried blood spots from children now 5 to 6 years of age for evidence of CMV DNA by polymerase chain reaction.…”

mentioning

confidence: 99%

“…The technique used for retrospective diagnosis in this study was an optimized DNA polymerase chain reaction on dried blood spots; with a sensitivity of around 85%, potentially 15% of children with cCMV were missed . Neonatal CMV DNA polymerase chain reaction on saliva (very easy to collect) has excellent sensitivity and specificity, and could be scaled up as a screening test.…”

mentioning

confidence: 99%