“…However, it should be noted that dermatological toxicities stand for the main immediate chemotherapy-induced adverse events, which are often unanticipated by patients (Gandhi et al, 2010;Hackbarth et al, 2008), and are mainly responsible for QoL impairment (Gandhi et al, 2010;Hackbarth et al, 2008;Ra et al, 2013;Sibaud et al, 2016). Besides, our results were confirmed by a large randomised clinical trial (PACThe study) in 251 patients, which investigated hydrotherapy as supportive treatment in women in breast cancer remission, shortly after chemotherapy completion (Kwiatkowski et al, 2013). This study showed significant positive effect on long-term QoL Follow-up studies would also be necessary to determine if hydrotherapy is a cost-effective approach in limiting dermatological sequelae and their negative impact on QoL.…”