Long-term in vivo corrosion behavior, biocompatibility and bioresorption mechanism of a bioresorbable nitrided iron scaffold

Lin, Woei; Q, Li; Qi, Haiping; Zhang, Deyuan; Gui, Zhilun; Gao, Runlin; Qiu, Hong; Xia, Ying; Cao, Peng; Wang, Xiang; Zheng, Wei

doi:10.1016/j.actbio.2017.03.020

Cited by 133 publications

(127 citation statements)

References 60 publications

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“…Despite additional alloying and processing, Fe corrosion rates are still lower than the benchmark ideal [17,20,21]. For example, recent long-term studies on biocorrosion of nitride iron scaffolds in rabbit abdominal aorta suggest completion of the degradation process in approximately 4 years [22]. …”

Section: Introductionmentioning

confidence: 99%

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

et al. 2017

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Metallic zinc implanted into the abdominal aorta of rats out to 6 months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20 months post-implantation, despite a steady buildup of passivating corrosion products and intense fibrous encapsulation of the wire. Although fibrous encapsulation was not able to prevent continued implant corrosion, it may be related to the reduced chronic inflammation observed between 10 and 20 months post-implantation. X-ray elemental and infrared spectroscopy analyses confirmed zinc oxide, zinc carbonate, and zinc phosphate as the main components of corrosion products surrounding the Zn implant. These products coincide with stable phases concluded from Pourbaix diagrams of a physiological solution and in vitro electrochemical impedance tests. The results support earlier predictions that zinc stents could become successfully bio-integrated into the arterial environment and safely degrade within a time frame of approximately 1 – 2 years.

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Section: Introductionmentioning

confidence: 99%

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

et al. 2017

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“…Several studies showed, however, that life-threatening complication, emerging several months or years after implantation, may occur, including restenosis due to neointimal hyperplasia and late in-stent thrombosis [2]. Novel therapeutic approaches to reduce persistent inflammation, stenosis and thrombosis are focused on antiproliferative and anti-inflammatory processes such as drug-eluting stents [3], pharmaceutical [4,5] or laser-based approaches [6,7] as well as bioresorbable stents [8].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, an appropriate animal model is paramount to foster the development of new therapies, to provide in vivo preclinical proof of concept, to evaluate the treatment performance and to promote translation to the clinic. The rabbitinjured iliac artery model has been well established to investigate the vascular response to hyperplasia and stenosis or thrombosis [3,8,9].…”

Section: Introductionmentioning

confidence: 99%

High-Resolution Ultrasound Imaging System for the Evaluation of the Vascular Response to Stent or Balloon Injuries in the Rabbit Iliac Arteries

Frobert¹,

Ajalbert²,

Valentin³

et al. 2020

Animal Models in Medicine and Biology

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For novel therapeutic approaches of cardiovascular diseases, the preclinical investigation is of paramount and required appropriate technologies. We investigated the use of high-resolution ultrasound imaging system to evaluate the progression of vascular lesions in a rabbit model. Animals underwent vascular injury using two standard procedures. A bare-metal stent was placed within the left iliac artery, and a balloon injury was induced in the contralateral artery. The animals were kept on a regular diet for 8 weeks. A Vevo3100© VisualSonic high-resolution ultrasound imaging system and the associated software VevoVasc were used for the longitudinal evaluation of the injured arteries and the distal abdominal aorta. The lumen size increased rapidly after the intervention in both iliac arteries. In the balloon-injured artery, the augmentation was transient and significantly reversed, inducing an alteration of the blow flow. In contrast, in the stented segment, the lumen size was maintained enlarged overtime. We demonstrated a significant correlation for the wall thickness and the lumen size between ultrasonic and histological quantification. High-resolution ultrasound imaging in rabbit iliac arteries and the distal abdominal aorta is feasible, reliable and of relevance to investigate novel strategies for the inhibition of hyperplasia induced with standard injury models.

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“…[1][2][3][4] Some of the possible alloys for such applications, especially in orthopaedics (bone-fixation screws, pins, plates, disks), are those based on Fe. [5][6][7][8][9][10][11][12][13] At the beginning of the healing process, injuries need stable mechanical properties to provide sufficient support. However, as the healing process progresses, the mechanical properties of the implants can be reduced, until finally they are no longer required.…”

Section: Introductionmentioning

confidence: 99%

“…Fe-based biodegradable metals offer a great potential for low, long-term exposure complications, chronic inflammation, side-effect risks or an inability to adapt to the implant. [12,15,[18][19][20] Biodegradable metals are also expected to have a positive interaction during the healing process, and with metals, the degradation process and its products are not supposed to adversely affect the healing process. Fe-Mn-based alloys have suitable characteristics for interactions with human tissue.…”

Section: Introductionmentioning

confidence: 99%

Improved biodegradability of Fe–Mn alloy after modification of surface chemistry and topography by a laser ablation

Donik

Kocijan

Paulin

et al. 2018

Applied Surface Science

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In this study we report the influence of laser ablation on the controlled biodegradability of a Fe-Mn alloy developed for medical implants. After texturing by a nanosecond Nd:YAG laser, the surface expressed extreme super-hydrophilic wetting properties, since laser ablation led to micro-channels and chemical modification resulting in nanostructured metal oxides. The influence of functionalized surface properties on corrosion behaviour was examined on molecular level by using X-ray photoelectron spectroscopy. Results reveal that the oxide layer after the laser texturing of Fe-Mn alloy consists mainly of Fe 2 O 3 and FeO, with the content of Mn in the oxide layer being significantly higher than in the bulk. The results of the electrochemical measurements clearly demonstrate the superior biodegradability of the Fe-Mn alloy samples functionalized by laser ablation. Here, the laser-triggered corrosion is selfdriven by further production of corrosion products that leads to biodegradability of the whole sample.

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Long-term in vivo corrosion behavior, biocompatibility and bioresorption mechanism of a bioresorbable nitrided iron scaffold

Cited by 133 publications

References 60 publications

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

High-Resolution Ultrasound Imaging System for the Evaluation of the Vascular Response to Stent or Balloon Injuries in the Rabbit Iliac Arteries

Improved biodegradability of Fe–Mn alloy after modification of surface chemistry and topography by a laser ablation

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