Long-term in vivo degradation and biocompatibility of degradable pHEMA hydrogels containing graphene oxide

Moura, Duarte; Rohringer, Sabrina; Ferreira, Helena P.; Pereira, Andreia T.; Barrias, Cristina C.; Magalhães, Fernão D.; Bergmeister, Helga; Gonçalves, Inês C.

doi:10.1016/j.actbio.2023.11.012

Cited by 15 publications

(6 citation statements)

References 42 publications

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“…Blood compatibility is an important indicator when considering the potential application of biomaterials in a blood environment [ 70 ]. According to the International Standards for Biomedical Materials (ISO70:10993), suitable biomedical materials should maintain stable chemical and physical properties when in contact with blood, while avoiding abnormal biological reactions [ 71 ].…”

Section: Resultsmentioning

confidence: 99%

Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Yu,

Yang,

Zhao

et al. 2024

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Yu,

Yang,

Zhao

et al. 2024

Materials Today Bio

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“…Histopathological examination of organs did not reveal any abnormalities. The incorporation of GO held promise for enhancing the stability and biocompatibility of degradable hydrogels in vivo, particularly for biomedical applications like blood-contacting devices . Further research, including in vivo studies and clinical trials, is necessary for a comprehensive understanding of the behavior of these materials.…”

Section: Properties Of 2d Nanomaterials Used In Healthcare Applicationsmentioning

confidence: 99%

“…The incorporation of GO held promise for enhancing the stability and biocompatibility of degradable hydrogels in vivo, particularly for biomedical applications like blood-contacting devices. 178 Further research, including in vivo studies and clinical trials, is necessary for a comprehensive understanding of the behavior of these materials. Future research should focus on optimizing the use of 2D nanoma- terials with minimal environmental impact and maximum safety.…”

Section: Healthcare Applicationsmentioning

confidence: 99%

Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring

Manoharan,

Batcha,

Mahalingam

et al. 2024

ACS Sens.

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The development of advanced technologies for the fabrication of functional nanomaterials, nanostructures, and devices has facilitated the development of biosensors for analyses. Two-dimensional (2D) nanomaterials, with unique hierarchical structures, a high surface area, and the ability to be functionalized for target detection at the surface, exhibit high potential for biosensing applications. The electronic properties, mechanical flexibility, and optical, electrochemical, and physical properties of 2D nanomaterials can be easily modulated, enabling the construction of biosensing platforms for the detection of various analytes with targeted recognition, sensitivity, and selectivity. This review provides an overview of the recent advances in 2D nanomaterials and nanostructures used for biosensor and wearable-sensor development for healthcare and healthmonitoring applications. Finally, the advantages of 2D-nanomaterial-based devices and several challenges in their optimal operation have been discussed to facilitate the development of smart highperformance biosensors in the future.

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“…Hydrogels offer the following advantages as DDSs: (1) Biocompatibility: Hydrogels closely resemble human tissues in their properties. When drugs are encapsulated within hydrogels, they not only avert the rapid degradation of chemotherapy drugs in the body but also shield the brain from drug-related toxicity [100][101][102]. (2) Biodegradability: Ideally, the interaction between the host tissue and the hydrogel should orchestrate and fine-tune the degradation process, leading to its eventual disappearance [103].…”

Section: Advantages Of Hydrogels In the Treatment Of Brain Tumorsmentioning

confidence: 99%

Advances in Hydrogels of Drug Delivery Systems for Local Treatment of Brain Tumors

Yang,

Wang,

et al. 2024

Preprint

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The management of brain tumors presents numerous challenges, despite the employment of multimodal therapies including surgical intervention, radiotherapy, chemotherapy, and immunotherapy. Owing to the distinct location of brain tumors and the presence of the blood-brain barrier (BBB), these tumors exhibit considerable heterogeneity and invasiveness at a histological level. Recent advancements in hydrogel research for the local treatment of brain tumors have sought to overcome the primary challenge of delivering therapeutics past the BBB, thereby ensuring efficient accumulation within brain tumor tissues. This article elaborates on various hydrogel-based delivery vectors, examining their efficacy in the local treatment of brain tumors. Additionally, it reviews the fundamental principles involved in designing intelligent hydrogels that can circumvent the BBB and penetrate larger tumor areas, thereby facilitating precise, controlled drug release. Hydrogel-based drug delivery systems (DDSs) are posited to offer a groundbreaking approach in addressing the challenges and limitations inherent in traditional oncological therapies, which are significantly impeded by the unique structural and pathological characteristics of brain tumors.

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Long-term in vivo degradation and biocompatibility of degradable pHEMA hydrogels containing graphene oxide

Cited by 15 publications

References 42 publications

Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Natural blackcurrant extract contained gelatin hydrogel with photothermal and antioxidant properties for infected burn wound healing

Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring

Advances in Hydrogels of Drug Delivery Systems for Local Treatment of Brain Tumors

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