Long-term in vivo operation of implanted cardiac nanogenerators in swine

Li, Jun; Hacker, Timothy A.; Wu, Hao; Long, Yin; Ni, Dalong; Rodgers, Allison C.; Cai, Weibo; Wang, Xudong

doi:10.1016/j.nanoen.2021.106507

Cited by 24 publications

(15 citation statements)

References 47 publications

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“…The interdigital electrode was affected by electrostatic induction, and the induced current was generated in the circuit. [ 16 ]…”

Section: Methodsmentioning

confidence: 99%

Self‐Powered Intelligent Voice Navigation Tactile Pavement Based on High‐Output Hybrid Nanogenerator

Jiang

et al. 2022

Adv Materials Technologies

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Improving the safety and usability of the blind movement is of great significance. The blind navigation system has always been the focus of attention. However, achieving an unconscious interaction and long‐term operation with high navigation accuracy is an urgent challenge. In this study, a distributed self‐powered intelligent voice navigation tactile pavement (SVP) based on a hybrid nanogenerator for blind navigation is reported. More than 4‐s effective output time is achieved under a single instantaneous pressure to the hybrid nanogenerator. The system is integrated with an inertial storage hybrid nanogenerator (ISNG), RF transmitter module, and voice broadcast module. It has the advantages of outstanding navigation accuracy, fatigue resistance (16 000 cycles), temperature stability (−50 to 50 °C), no required operation, and easy fabrication. The SVP may solve the difficulties of GPS navigation delay and lack of map information and realize the accurate identification and feedback of key locations, providing an effective and unconscious interaction navigation strategy for the blind. Integrating the hybrid nanogenerator under the road can provide an energy supply for the construction of the Internet of Things and smart city in the future.

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“…The interdigital electrode was affected by electrostatic induction, and the induced current was generated in the circuit. [ 16 ]…”

Section: Methodsmentioning

confidence: 99%

Self‐Powered Intelligent Voice Navigation Tactile Pavement Based on High‐Output Hybrid Nanogenerator

Jiang

et al. 2022

Adv Materials Technologies

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“…Self-powered sensors with low or zero power consumption and high performance for monitoring physiological signals (e.g., for active endocardial monitoring) will make strengths in real-time medical monitoring. Li et al evaluated the safety of a soft and flexible implantable nanogenerators (i-NG) system for long-term in vivo cardiac implantation [ 68 ]. The system consisted of piezoelectric PVDF-based i-NG, leads, and receivers were implanted into the epicardial membrane of pigs for two months.…”

Section: Biomechanical Monitoring In the Cardiovascular Systemmentioning

confidence: 99%

“…Reprinted/adapted with permission from Ref. [ 68 ]. ( B ) Schematic diagram of the mechanism for monitoring blood flow velocity by iTEAS.…”

Section: Figurementioning

confidence: 99%

Mechanical Sensors for Cardiovascular Monitoring: From Battery-Powered to Self-Powered

Tang

Liu

2022

Biosensors

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Cardiovascular disease is one of the leading causes of death worldwide. Long-term and real-time monitoring of cardiovascular indicators is required to detect abnormalities and conduct early intervention in time. To this end, the development of flexible wearable/implantable sensors for real-time monitoring of various vital signs has aroused extensive interest among researchers. Among the different kinds of sensors, mechanical sensors can reflect the direct information of pressure fluctuations in the cardiovascular system with the advantages of high sensitivity and suitable flexibility. Herein, we first introduce the recent advances of four kinds of mechanical sensors for cardiovascular system monitoring, based on capacitive, piezoresistive, piezoelectric, and triboelectric principles. Then, the physio-mechanical mechanisms in the cardiovascular system and their monitoring are described, including pulse wave, blood pressure, heart rhythm, endocardial pressure, etc. Finally, we emphasize the importance of real-time physiological monitoring in the treatment of cardiovascular disease and discuss its challenges in clinical translation.

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“…In addition, biomedical energy harvesters, especially bio-implantable energy harvesters, are required to be biocompatible, which necessitates biocompatible device components including piezoelectric material, electrode, substrate, and encapsulation [ 75 ]. For piezoelectric biomedical energy harvesters, electrode materials have been reported including Cr [ 76 ], Ag [ 77 ], Cu [ 78 ], Au [ 76 ], Al [ 79 ], graphene [ 80 ], and indium tin oxide (ITO) [ 81 ], substrate materials have been reported including plastic films (e.g., polyethylene terephthalate (PET) [ 82 , 83 ], and polyimide(PI) [ 84 ]) and metallic foils (e.g., Ni [ 85 ], Pt [ 86 ], and Ni–Cr alloy [ 87 ]), and encapsulation materials have been reported such as PI [ 84 ], PDMS [ 88 ], and PDMS/Parylene-C [ 89 ]. Initial studies have confirmed their biosafety [ 76 , 89 ], but long-term biocompatibility studies using large animal models or clinical studies are highly desired to conclude on their long-term biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…For piezoelectric biomedical energy harvesters, electrode materials have been reported including Cr [ 76 ], Ag [ 77 ], Cu [ 78 ], Au [ 76 ], Al [ 79 ], graphene [ 80 ], and indium tin oxide (ITO) [ 81 ], substrate materials have been reported including plastic films (e.g., polyethylene terephthalate (PET) [ 82 , 83 ], and polyimide(PI) [ 84 ]) and metallic foils (e.g., Ni [ 85 ], Pt [ 86 ], and Ni–Cr alloy [ 87 ]), and encapsulation materials have been reported such as PI [ 84 ], PDMS [ 88 ], and PDMS/Parylene-C [ 89 ]. Initial studies have confirmed their biosafety [ 76 , 89 ], but long-term biocompatibility studies using large animal models or clinical studies are highly desired to conclude on their long-term biocompatibility. In terms of piezoelectric material, high-performance lead-free piezoelectric ceramics [ 90 , 91 ] and piezoelectric polymers [ 2 ] have been widely reported to be biocompatible, while lead-based ceramics may also be biocompatible in the crystalline state [ 92 ] or under proper encapsulation [ 84 ].…”

Section: Introductionmentioning

confidence: 99%

Expedient secondary functions of flexible piezoelectrics for biomedical energy harvesting

Wang

Hong

Venezuela

et al. 2023

Bioactive Materials

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Long-term in vivo operation of implanted cardiac nanogenerators in swine

Cited by 24 publications

References 47 publications

Self‐Powered Intelligent Voice Navigation Tactile Pavement Based on High‐Output Hybrid Nanogenerator

Self‐Powered Intelligent Voice Navigation Tactile Pavement Based on High‐Output Hybrid Nanogenerator

Mechanical Sensors for Cardiovascular Monitoring: From Battery-Powered to Self-Powered

Expedient secondary functions of flexible piezoelectrics for biomedical energy harvesting

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