Long-term intermittent cold exposure affects peri-ovarian adipose tissue and ovarian microenvironment in rats

Zhang, Li; An, Gaihong; Wu, Shuai; Wang, Jing; Yang, Dongyan; Zhang, Yongqiang; Xi, Li

doi:10.1186/s13048-021-00851-8

Cited by 2 publications

(4 citation statements)

References 44 publications

(61 reference statements)

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“…Here, and in Table 2, we outline the effects of ICE on body weight (BW), adipose tissue weight (white adipose tissue (WAT) and brown adipose tissue (BAT), adipose tissue morphology (WAT and BAT), EE, and outcomes that may be related to EE. Winter swimmers: higher supraclavicular skin temp in response to cold exposure, no BAT glucose uptake at thermoneutrality (controls had glucose uptake at thermoneutrality), ↑glucose uptake in perirenal BAT during cold exposure (not significant for control), ↑REE during cold exposure Humans Zhang [37] ↓BW, ↑EI (trend) Rats McKie [38] ↑BW, ↑iWAT, ↑eWAT, ↑BAT, ↑EI, ↑↑EI (within 4 h post ICE) Obese Mice Weng [39] ↑sWAT, ↔vWAT Obese Rats Nema [9] ↔BW, ↔BMI, ↔FM, ↔FFM, ↓Waist Circumference (men only) Humans (Soldiers)…”

Section: Ice Effects On Body Weight Energy Expenditure and Adipose Ti...mentioning

confidence: 99%

“…Obese Mice Caloric Restriction During ICE 24 h ad libitum after ICE Zhang [37] ↑peri-ovarian adipose thermogenic gene expression (Ucp1, PGC1α, Prdm16, Fndc5) Rats Weng [39] ↔iWAT ATGL activity, ↑iWAT LPL activity Obese Rats…”

Section: Ice Effects On Adipose Tissue Gene and Protein Expressionmentioning

confidence: 99%

“…The effects of ICE on BW are mixed, with studies reporting increases [ 21 , 25 , 33 , 38 ], decreases [ 19 , 22 , 37 ], and null effects [ 9 , 24 , 27 , 29 , 30 , 35 ]. Still, the methodologies were varied, and a closer look provides some potential insights.…”

Section: Ice Effects On Body Weight Energy Expenditure and Adipose Ti...mentioning

confidence: 99%

“…An overall null effect of ICE on BW is expected when the balance between the EE and energy intake (EI) is maintained, and an expected increase in EI, as an effect of ICE, is reported by most studies [ 19 , 23 , 27 , 37 , 38 ]. Interestingly, Yoo et al capped the EI to pre-ICE intervention levels and still reported an increase in BW [ 25 ].…”

Section: Ice Effects On Body Weight Energy Expenditure and Adipose Ti...mentioning

confidence: 99%

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The Effects of Intermittent Cold Exposure on Adipose Tissue

Scott,

Fuller

2023

IJMS

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Intermittent cold exposure (ICE) has garnered increased attention in popular culture, largely for its proposed effects on mood and immune function, but there are also suggestions that the energy-wasting mechanisms associated with thermogenesis may decrease body weight and fat mass. Considering the continued and worsening prevalence of obesity and type II diabetes, any protocol that can reduce body weight and/or improve metabolic health would be a substantial boon. Here, we present a narrative review exploring the research related to ICE and adipose tissue. Any publicly available original research examining the effects of repeated bouts of ICE on adipose-related outcomes was included. While ICE does not consistently lower body weight or fat mass, there does seem to be evidence for ICE as a positive modulator of the metabolic consequences of obesity, such as glucose tolerance and insulin signaling. Further, ICE consistently increases the activity of brown adipose tissue (BAT) and transitions white adipose tissue to a phenotype more in line with BAT. Lastly, the combined effects of ICE and exercise do not seem to provide any additional benefit, at least when exercising during ICE bouts. The majority of the current literature on ICE is based on rodent models where animals are housed in cold rooms, which does not reflect protocols likely to be implemented in humans such as cold water immersion. Future research could specifically characterize ICE via cold water immersion in combination with controlled calorie intake to clearly determine the effects of ICE as it would be implemented in humans looking to lower their body weight via reductions in fat mass.

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Section: Ice Effects On Body Weight Energy Expenditure and Adipose Ti...mentioning

confidence: 99%

Section: Ice Effects On Adipose Tissue Gene and Protein Expressionmentioning

confidence: 99%

Section: Ice Effects On Body Weight Energy Expenditure and Adipose Ti...mentioning

confidence: 99%

Section: Ice Effects On Body Weight Energy Expenditure and Adipose Ti...mentioning

confidence: 99%

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The Effects of Intermittent Cold Exposure on Adipose Tissue

Scott,

Fuller

2023

IJMS

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Does the ovarian surface epithelium differentiate into primordial follicle and primary follicle precursor structures?

Ünal

Seçme

2022

Cukurova Medical Journal

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Purpose: The aim of this study is to investigate the differentiation capacity of ovarian surface epithelial cells both in cell culture conditions and in ovarian tissue sections. Materials and Methods: The ovaries of two prepubertal (4 weeks old) female rats were divided into small pieces and explant cell culture was created. Ovarian surface epithelium proliferating together with ovarian stromal cells in mixed cell culture was isolated and reproduced. In addition, ovarian surface epithelium was examined in histological sections of ovarian tissue and images were taken under the microscope. Results: The morphological appearance of the ovarian surface epithelium was found to be cobblestone. In the count performed under phase contrast microscopy, it was observed that 2x106 and 3x106 cells were grown in the culture dishes, respectively. Primordial follicle-like structures were observed in some areas of the petri dishes. On the histological sections, primordial and primary follicle precursor structures were observed on the basement membrane. Conclusion: Showing oocyte markers (Gdf-9, C-Mos, Zpc, Stella) and germ cell markers (Dazl, Vasa, Blimp1, Fragilis) both in cell cultures and in histological sections can give us valuable information in terms of monitoring the differentiation capacity of these cells.

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Long-term intermittent cold exposure affects peri-ovarian adipose tissue and ovarian microenvironment in rats

Cited by 2 publications

References 44 publications

The Effects of Intermittent Cold Exposure on Adipose Tissue

The Effects of Intermittent Cold Exposure on Adipose Tissue

Does the ovarian surface epithelium differentiate into primordial follicle and primary follicle precursor structures?

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