Long-Term Lemonade Based Dietary Manipulation in Patients With Hypocitraturic Nephrolithiasis

Kang, David E.; Sur, Roger L.; Haleblian, George E.; Fitzsimons, Nicholas J.; Borawski, Kristy M.; Preminger, Glenn M.

doi:10.1016/j.juro.2006.11.058

Cited by 104 publications

(54 citation statements)

References 15 publications

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“…Meanwhile, citric acid is naturally concentrated in citrus fruits with lemon juice and lime juice being rich sources of citric acid and intake of these has been suggested as an effective means of treating oxalate stones. 1,51,52 These studies have addressed the utility of dietary intervention with fruits and fruit juices with high citrate content (orange juice and lemonade) as an alternative to potassium citrate in increasing urinary pH and citrate, but the combination of citrate supplementation and fruit juices was not evaluated. This latter approach might prove a useful one combining the advantages of both classes of food additives.…”

Section: 26mentioning

confidence: 99%

Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice

Abdel-Salam

Youness²,

Mohammed³

et al. 2014

Journal of Medicinal Food

129

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Citric acid is a weak organic acid found in the greatest amounts in citrus fruits. This study examined the effect of citric acid on endotoxin-induced oxidative stress of the brain and liver. Mice were challenged with a single intraperitoneal dose of lipopolysaccharide (LPS; 200 lg/kg). Citric acid was given orally at 1, 2, or 4 g/kg at time of endotoxin injection and mice were euthanized 4 h later. LPS induced oxidative stress in the brain and liver tissue, resulting in marked increase in lipid peroxidation (malondialdehyde [MDA]) and nitrite, while significantly decreasing reduced glutathione, glutathione peroxidase (GPx), and paraoxonase 1 (PON1) activity. Tumor necrosis factor-alpha (TNF-a) showed a pronounced increase in brain tissue after endotoxin injection. The administration of citric acid (1-2 g/kg) attenuated LPS-induced elevations in brain MDA, nitrite, TNF-a, GPx, and PON1 activity. In the liver, nitrite was decreased by 1 g/kg citric acid. GPx activity was increased, while PON1 activity was decreased by citric acid. The LPS-induced liver injury, DNA fragmentation, serum transaminase elevations, caspase-3, and inducible nitric oxide synthase expression were attenuated by 1-2 g/kg citric acid. DNA fragmentation, however, increased after 4 g/kg citric acid. Thus in this model of systemic inflammation, citric acid (1-2 g/kg) decreased brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation.

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Section: 26mentioning

confidence: 99%

Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice

Abdel-Salam

Youness²,

Mohammed³

et al. 2014

Journal of Medicinal Food

129

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“…In a couple of previous studies, caffeine increased urinary magnesium and citrate in both stone formers and non stone formers [26,46]. The administration of citrate-containing fluids has been recommended as optimal for stone prevention by a number of investigators [47,48,49]. Thus, the decreases in risk seen after caffeine consumption in our results may partly be attributed to the beneficial increase in urinary magnesium and citrate, which was not impaired by the detrimental increase in urinary calcium.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Coffee Intake and Risk of Urolithiasis

Wang¹,

Zhang²,

Mao³

et al. 2014

Urol Int

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Objective: Epidemiologic studies have reported various results relating coffee to urolithiasis. A meta-analysis of cohort and case-control studies was conducted to pool the relative risk (RR) estimates of the association between coffee and urolithiasis. Methods: Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary RR estimates. A dose-response meta-analysis was performed for studies reporting categorical RR estimates for a series of exposure levels. Results: A total of 6 studies (2 cohort and 4 case-control studies) on coffee intake were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest coffee consumption (OR = 0.70, 95% confidence interval 0.60-0.82) on the risk of urolithiasis. Coffee exhibited an inverse dose-response relationship with urolithiasis. In stratified analysis, a significant inverse association between coffee and urolithiasis was observed in study design, geographical region and gender subgroup. Conclusions: The overall current literature suggests that coffee intake is associated with a decreased risk of urolithiasis. Further efforts should be made to clarify the underlying biological mechanisms.

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“…Consumption of sugary drinks such as soda-pop or fruit juice sweetened with high-fructose corn syrup has been associated with increased risk of incident kidney stones [8]. Lemonade consumption has been shown to reduce recurrence in adults with hypocitraturic nephrolithiasis in some studies [9] but not in others [10, 11•]. The accompanying cation is important.…”

Section: Treatment Diet and Lifestylementioning

confidence: 99%

Urolithiasis in Children—Treatment and Prevention

Jackson

Avendt-Reeber

2016

Curr Treat Options Peds

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Long-Term Lemonade Based Dietary Manipulation in Patients With Hypocitraturic Nephrolithiasis

Abstract: Due to its significant citraturic effect, lemonade therapy appears to be a reasonable alternative for patients with hypocitraturia who cannot tolerate first line therapy. Future study in the form of a prospective, randomized trial is needed to validate these findings.

Cited by 104 publications

References 15 publications

Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice

Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice

A Meta-Analysis of Coffee Intake and Risk of Urolithiasis

Urolithiasis in Children—Treatment and Prevention

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