Long-term levetiracetam treatment in patients with epilepsy: 3-year follow up

Abstract

Levetiracetam is an effective and well-tolerated option for long-term treatment of epilepsy in adults.

Antiepileptic drug discontinuation by people with epilepsy in the general population

“…Discontinuation for lack of efficacy was most common with γ‐aminobutyric acidergic drugs, whereas discontinuation for adverse events was mostly seen with topiramate, phenytoin, carbamazepine, and levetiracetam, in decreasing order. These findings are not unexpected, although the rates differ from those of other reports on account of differing prescribing patterns and different populations at risk.…”

Efficacy and safety of levetiracetam for migraine prophylaxis: A systematic review

“…The studies conducted for 6 months indicated that levetiracetam remains effective for migraine prophylaxis for the en- TA B L E 2 Recommended dosing schedule of levetiracetam for migraine prophylaxis [21][22][23][24][25][26][27][28] mood disorders such as irritability, which often were transient or could be improved by decreasing the dose. 32,33 Patients may find these adverse effects to be an acceptable risk if long-term efficacy is established.…”

Efficacy and Tolerability of Levetiracetam (Keppra®) in the Treatment of Epilepsy: Review of Literature

“…Однако на фоне приема леветирацетама наруше-ния поведения встречаются с частотой 10-51 % и включают также тревогу, эмоциональную лабиль-ность, невротические реакции, апатию, депрессию [20,53,58,69,72,89]. Леветирацетам может вызывать или усиливать возбудимость, раздражительность, ко-лебания настроения и агрессивность [25].…”

“…В зарубежной литературе при приеме леветирацетама описаны случаи усиления возбудимо-сти, раздражительности, колебаний настроения и пе-риодической агрессивности [20,25,58,72,81,89]. Важно иметь в виду, что усиление раздражительности и возбудимости может усиливать проявления СДВГ у больных эпилепсией [9].…”