Long-term melatonin treatment prolongs interestrus, but does not delay puberty, in domestic cats

Suppression of Fertility in Adult Cats

“…), but not to delay puberty (Faya et al. ). The duration of efficacy seemed to depend on the stage of oestrous cycle when animals were treated with a prolonged duration of efficacy in interoestrus compared with oestrus (113.3 ± 6.1 vs. 61.1 ± 6.8 days) (Gimenez et al.…”

“…Without sufficient care, they might induce severe side effects (Johnston et al 2001;Munson 2006;Greenberg et al 2013) such as cystic endometrial hyperplasia-pyometra complex (Agudelo 2005), mammary tumours and fibroadenomatosis (Wehrend et al 2001;Loretti et al 2005) and insulin resistance causing diabetes mellitus (Johnston et al 2001;Munson 2006). According to the literature, differences regarding the frequency of side effects exist depending on the active ingredient (with a significantly lower frequency observed after megestrol acetate and proligestone treatment compared to medroxyprogesterone acetate) and depending on the duration of treatment Differences between two studies published (Gimenez et al 2009, Faya et al 2011 Leaflet recommendation refers to national registrations in Germany: Intervet Deutschland GmbH, 85716 Unterschleissheim, Germany; Albrecht GmbH, 88326 Aulendorf, Germany; Selectavet Dr. Otto Fischer GmbH, 83629 Weyarn-Holzolling, Germany.…”

“…Melatonin is available on the veterinary market and licensed as an 18 mg implant for oestrus induction in sheep, a 'short-day breeder' (Melovine â ; CEVA Sant e Animal, Libourne, France). So, further studies were conducted showing that the use of the melatonin implant is a promising option for short-term post-ponement of oestrus, while preserving the future reproductive potential (Gimenez et al 2009;Faya et al 2011), but not to delay puberty (Faya et al 2011). The duration of efficacy seemed to depend on the stage of oestrous cycle when animals were treated with a prolonged duration of efficacy in interoestrus compared with oestrus (113.3 AE 6.1 vs. 61.1 AE 6.8 days) (Gimenez et al 2009).…”

“…The duration of efficacy seemed to depend on the stage of oestrous cycle when animals were treated with a prolonged duration of efficacy in interoestrus compared with oestrus (113.3 AE 6.1 vs. 61.1 AE 6.8 days) (Gimenez et al 2009). In a more recent study, Faya et al (2011) investigated 41 anovulatory cycles of 28 queens comparing oral (4 mg/cat/day, n = 12) to implant (18 mg, n = 17) melatonin treatment in interoestrus. Both interoestrous interval (p < 0.01) and treatment to oestrous interval (p < 0.05) were significantly longer in both melatonin groups compared with untreated controls, but did not differ between oral and implant treatment (interoestrous intervals were as follows: 63.8 AE 5.4 days, implant; 63.0 AE 5.3 days, oral; and 19.2 AE 1.4 days, untreated, respectively).…”

Medicamenteuze contraceptie bij de kat is nodig

“…Ook zijn er in enkele andere landen discussie en controverse over het opereren van een gezond dier. Bovendien is sterilisatie of castratie van zwerfkatten voor vele regio's duur, arbeidsintensief en technische kennis van een dierenarts is noodzakelijk (Faya et al, 2011;Levy et al, 2011;Goericke-Pesch et al, 2013;Goericke-Pesch et al, 2014a;Lucas, 2014). In dit artikel wordt een overzicht gegeven van de recente ontwikkelingen van medicamenteuze contraceptie bij de kattin en de kater en wordt de noodzaak van verplichte sterilisatie van raskatten of rasloze binnenkatten in vraag gesteld.…”