Long-term metabolic, cardiovascular and neoplastic risks with polycystic ovary syndrome

Cattrall, Fleur R; Healy, David

doi:10.1016/j.bpobgyn.2004.05.005

Cited by 46 publications

(33 citation statements)

References 52 publications

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“…The risk of ovarian and breast cancer was not increased in patients with PCOS (122,123,124), whereas the risk of ovarian cancer was increased in patients aged <50 years (123).…”

Section: Cancer Diseasementioning

confidence: 89%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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“…The risk of ovarian and breast cancer was not increased in patients with PCOS (122,123,124), whereas the risk of ovarian cancer was increased in patients aged <50 years (123).…”

Section: Cancer Diseasementioning

confidence: 89%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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“…Sin embargo, en las pacientes con SOP obesas existiría una acción sinérgica, donde todas presentaron alteraciones en RI y/o BTG, por lo que estas pacientes constituyen un grupo de alto riesgo para desarrollar trastornos cardiovasculares (23,27), diabetes mellitus tipo II (24,29), enfermedad coronaria y dislipidemia (17,30). En este gru- po de pacientes existe una tendencia a presentar niveles de testosterona total más altos, lo cual podría contribuir en la génesis de la obesidad encontrada en estas pacientes.…”

Section: Discussionunclassified

“…(14) comunicaron una correlación significativa entre los niveles de andrógenos y los de insulina en pacientes con SOP, encontrándose algunos años más tarde resistencia a la insulina (RI) y SOP en mujeres tanto obesas como normales (15). Algunos estudios han demostrado que al menos 50% del total de pacientes con SOP presenta obesidad (1, 16,17), siendo ésta predominantemente de tipo andrógena o central, manifestándose por un índi-ce cintura/cadera aumentado (>0,85). Este tipo de obesidad se ha asociado con hiperandrogenemia, RI, baja tolerancia a la glucosa (BTG) y dislipidemia (18)(19)(20)(21).…”

Section: Introductionunclassified

Análisis De Resistencia Insulínica, Tolerancia a La Glucosa Y Testosterona en Mujeres Jóvenes Con Síndrome De Ovario Poliquístico Agrupadas Por Índice De Masa Corporal

Cortés³

et al. 2006

Rev. chil. obstet. ginecol.

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RESUMENAntecedentes: El síndrome de ovario poliquístico (SOP) es el desorden endocrino más común en las mujeres en edad reproductiva. Han sido asociadas al SOP resistencia a la insulina, obesidad y diabetes mellitus. Objetivo: Analizar en mujeres con SOP la relación entre testosterona, obesidad y problemas en el metabolismo de carbohidratos. Pacientes y Métodos: 60 pacientes, entre 14-32 años, fueron diagnosticadas según Consenso de Rotterdam. Se midió testosterona total (T total ), se realizó un test de tolerancia oral a glucosa e insulina (TTOG-I) y se calculó índice de masa corporal (IMC) en todas las pacientes. La distribución de cada variable y la relación entre testosterona y las otras variables fueron analizadas. Resultados: La media de T total en todas las pacientes fue 2,2 nmol/L; 71,7% de los sujetos presentan IMC normal, 21,7% presentan IMC sobrepeso y 6,6% presenta IMC obeso. La media de T total para cada grupo según IMC fue 2,2 nmol/L para normal y sobrepeso, y 2,75 nmol/L para obeso. Para TTOG-I, 43,3% tiene respuesta normal, con media de T total = 2,2 nmol/L y media de IMC= 22,3 kg/m 2 , 56,7% tiene respuesta anormal, con media de T total = 2,19 nmol/L e IMC= 23,1 kg/m 2 . Las pacientes normales y sobrepeso muestran respuesta similar al TTOG-I. Todas las pacientes obesas tienen TTOG-I alterado. Conclusiones: La alta prevalencia de desórdenes metabólicos apoya el hecho que éstos deben ser estudiados en estas pacientes. La ausencia de correlación significativa entre T total y las otras variables sugiere que en el SOP múltiples factores están involucrados y que éste incluye diferentes subpoblaciones de pacientes, que requieren un diagnóstico adecuado. La clasificación de las pacientes con SOP en subgrupos podría ser útil antes del inicio del tratamiento.

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“…by its association with the metabolic syndrome, it is still a topic of debate [10]. Studies demonstrate that in patients with PCOS, even if the criteria for the metabolic syndrome are not fully met, there is at least one component of the metabolic syndrome [11].…”

Section: Increased Insulin Resistancementioning

confidence: 99%

Lifestyle Changes and Weight Loss: Effects in PCOS

Ionescu¹,

Popescu²,

Banacu³

et al. 2018

Debatable Topics in PCOS Patients

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Even though controversies surrounding the polycystic ovary syndrome are not yet close to be solved, its clinical manifestations are well known-insulin resistance and obesity, hirsutism, irregular and anovulatory menstrual cycles. The treatment of polycystic ovarian syndrome (PCOS) is mainly symptomatic as its etiology is not yet clear. Lifestyle changes are the primary therapy in overweight and obese women with PCOS. According to majority of the studies, lifestyle changes are the most efective form of treatment not only for weight loss but also for the improvement of insulin sensitivity, decreasing incidence of metabolic syndrome and type 2 diabetes. Studies also show that weight loss has fertility beneits by restoring ovulatory cycles. Although initial studies researching pharmacologic treatment were showing excellent results concerning the weight loss, maintenance of weight loss and reduction of cardiovascular risks, some of these drugs were in the end, has proven to actually increase the risk for cardiovascular events and were removed from the market. Bariatric surgery has been demonstrated to improve or even cure type 2 diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea. More so, there are studies that reported complete resolution of all features of PCOS, even hirsutism, hyperandrogenism, anovulation, and menstrual irregularity.

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Long-term metabolic, cardiovascular and neoplastic risks with polycystic ovary syndrome

Cited by 46 publications

References 52 publications

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Análisis De Resistencia Insulínica, Tolerancia a La Glucosa Y Testosterona en Mujeres Jóvenes Con Síndrome De Ovario Poliquístico Agrupadas Por Índice De Masa Corporal

Lifestyle Changes and Weight Loss: Effects in PCOS

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