Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway

Wang, Shi Qiang; Li, Dan; Yuan, Yang

doi:10.1007/s12576-019-00696-3

Cited by 47 publications

(45 citation statements)

References 52 publications

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“…As a specific inhibitor of Smad3, there is no doubt about the blocking effect of SIS3 on the TGF‐ β /Smad3 pathway [23,24]. Commonly, Smad3 and other components in the TGF‐ β /Smad3 signaling pathway were accumulated in patients with T2DM [25,26], and the inhibitions of TGF‐ β /Smad3 signaling pathway were conducive to the treatment of T2DM [27–29]. Therefore, SIS3 is expected to have a good effect on T2DM, due to its inhibitory effect on Smad3.…”

Section: Discussionmentioning

confidence: 99%

SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice

Wang

Yan

Cui

et al. 2020

Fundamemntal Clinical Pharma

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TGF‐β signaling plays an extremely important role in the occurrence and development of type 2 diabetes mellitus (T2DM), and the blockade of TGF‐β/Smad3 pathway protests against the high‐fat diet‐induced obesity and diabetes. As a specific small molecule inhibitor of Smad3 protein, the biological activities of compound SIS3 were evaluated by high‐fat diet‐induced T2DM model mice. In vivo results indicated that SIS3 can not only significantly reduce the body weight, fat mass, and fasting blood glucose in high‐fat diet‐induced T2DM model mice, but also improve insulin sensitivity and oral glucose tolerance of high‐fat diet‐induced T2DM model mice after the injection of SIS3 with 5 mg/kg for 45 days.

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Section: Discussionmentioning

confidence: 99%

SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice

Wang

Yan

Cui

et al. 2020

Fundamemntal Clinical Pharma

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“…The low level of ROS can regulate specific signal pathways, and too many ROS participate in the pathogenesis of many fibrotic diseases such as tendon adhesion [ 26 – 28 ]. It can be attenuated by various antioxidant enzymes such as SOD and GPx, which could indirectly reflect the oxidative state [ 29 , 30 ]. Malondialdehyde (MDA, a marker of lipid peroxidation) is usually used as a biomarker of oxidative damage [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin reduces tendon adhesion in rat through suppression of oxidative stress

Liang

Zhang

et al. 2020

BMC Musculoskelet Disord

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Background Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as a popular drug at present, it has various biological functions, including anti-inflammatory, anti-ischemic, anti-peroxidation, and antioxidant. The purpose of this study was to investigate the effect of quercetin on tendon adhesion and whether quercetin can inhibit oxidative stress. Method Thirty-six rats were randomly divided into three groups, including control group, low QUE (50 mg/kg/day) group, and high QUE (100 mg/kg/day) group. After 1 week, the levels of SOD, MDA and GPx were measured. The degree of tendon adhesion was assessed by macroscopic evaluation and histological evaluation. After 4 weeks. Besides, the pharmacological toxicity of quercetin to main organs were evaluated by histological analysis. Results The extent of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of tendon tissue in high QUE group was significantly higher than those of low QUE group and control group. And the extent of malondialdehyde (MDA) of tendon tissue in high QUE group was significantly lower than that of low QUE group and control group. By macroscopic evaluation and histological analysis, the extent of tendon adhesion in high QUE group was lower than low QUE group and control group. However, there were no significant changes of the major organs through histological analysis. Conclusions Quercetin may be a good and safe strategy in preventing tendon adhesion. But further clinical research is needed before its recommendation in the prevention and treatment of tendon adhesion.

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“…A balance between free radical production and antioxidant capacity is critical, and oxidative stress results from the accumulation of oxidative products [57]. The excess formation of oxidants can cause oxidative stress [3,58,59]. A HFD increases plasma-free fatty acids and induces oxidative stress from the accumulation of lipid peroxidation in the hippocampus [60].…”

Section: Discussionmentioning

confidence: 99%

Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats

et al. 2020

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High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders. This study aimed to examine the neuroprotective impacts of the H. scabrum Ext on hippocampal synaptic plasticity in rats that were fed HFD. Fifty-four male Wistar rats (220 ± 10 g) were randomly arranged in six groups: (1) HFD group; (2) HFD + Ext300 group; (3) HFD + Ext100 group; (4) Control group; (5) Ext 300 mg/kg group; (6) Ext 100 mg/kg group. These protocols were administrated for 3 months. After this stage, a stimulating electrode was implanted in the perforant pathway (PP), and a bipolar recording electrode was embedded into the dentate gyrus (DG). Long-term potentiation (LTP) was provoked by high-frequency stimulation (HFS) of the PP. Field excitatory postsynaptic potentials (EPSP) and population spikes (PS) were recorded at 5, 30, and 60 min after HFS. The HFD group exhibited a large and significant decrease in their PS amplitude and EPSP slope as compared to the control and extract groups. In reverse, H. scabrum administration in the HFD + Ext rats reversed the effect of HFD on the PS amplitude and EPSP slope. The results of the study support that H. scabrum Ext can inhibit diminished synaptic plasticity caused by the HFD. These effects are probably due to the extreme antioxidant impacts of the Ext and its capability to scavenge free radicals.

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Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway

Cited by 47 publications

References 52 publications

SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice

SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice

Quercetin reduces tendon adhesion in rat through suppression of oxidative stress

Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats

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