2020
DOI: 10.1002/cam4.3669
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Long‐term monitoring of dynamic changes in plasma EBV DNA for improved prognosis prediction of nasopharyngeal carcinoma

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cited by 20 publications
(17 citation statements)
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“…We clarified the clinical validity of nonviral ctDNA monitoring using individualized dPCR primer‐probes in HNSCC patients. ctDNA monitoring in HNSCC has been previously reported in nasopharyngeal carcinoma, where detection of EBV‐DNA in plasma is associated with recurrence rate, overall survival, and relapse‐free survival 16,17 . Recently, there have been many reports of HPV‐related OPC in which the E6/E7 genes were detected in the plasma, and treatment efficacy and recurrence were monitored 13,18 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We clarified the clinical validity of nonviral ctDNA monitoring using individualized dPCR primer‐probes in HNSCC patients. ctDNA monitoring in HNSCC has been previously reported in nasopharyngeal carcinoma, where detection of EBV‐DNA in plasma is associated with recurrence rate, overall survival, and relapse‐free survival 16,17 . Recently, there have been many reports of HPV‐related OPC in which the E6/E7 genes were detected in the plasma, and treatment efficacy and recurrence were monitored 13,18 .…”
Section: Discussionmentioning
confidence: 99%
“…ctDNA monitoring in HNSCC has been previously reported in nasopharyngeal carcinoma, where detection of EBV‐DNA in plasma is associated with recurrence rate, overall survival, and relapse‐free survival. 16 , 17 Recently, there have been many reports of HPV‐related OPC in which the E6/E7 genes were detected in the plasma, and treatment efficacy and recurrence were monitored. 13 , 18 Thus, in some HNSCCs caused by viruses such as HPV and EBV, detecting virus‐derived genes in plasma is expected to be a useful biomarker.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, EBV DNA levels are highly prognostic for survival in patients with NPC [ 37 ]. Furthermore, Li et al [ 38 ] reported that long-term monitoring of dynamic changes in plasma EBV DNA may improve the prognostic prediction of NPC. The dynamic changes in plasma EBV DNA before and after therapy may predict long-term survival and provide accurate risk stratification for NPC.…”
Section: Discussionmentioning
confidence: 99%
“…The infection of EBV is common in NPC in endemic areas. Levels of plasma EBV DNA have been shown to be the most attractive potential biomarker to predict prognosis and provide accurate risk stratification in NPC [ 20 ]. Intriguingly, a recent prospective screening study that involved 20,174 participants showed that plasma EBV DNA detection was useful to screen for NPC, as it was associated with 97.1% sensitivity and 98.6% specificity.…”
Section: Discussionmentioning
confidence: 99%