Long-term morbidity and quality of life in patients with localized prostate cancer undergoing definitive radiotherapy or radical prostatectomy

Lilleby, Wolfgang; Fosså, Sophie D.; Wæhre, Håkon; Olsen, Dag Rune

doi:10.1016/s0360-3016(98)00475-1

Cited by 172 publications

(96 citation statements)

References 37 publications

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“…Monga et al, 12 in a study meeting this requirement, found the rate of severe fatigue to be 40% among RAD patients with no initial ADT, at a mean time of 16.2 months after initiation of RAD, however, without identification of current hormone users. Our observations add to the results of these studies of fatigue in prostate cancer survivors, [9][10][11][12][13] showing that fatigue is a problem after local treatment even in patients without ADT.…”

Section: Discussionsupporting

confidence: 75%

“…Younger age at diagnosis, high neuroticism, presence of pain, post-treatment co-morbidity and urinary and intestinal dysfunction were significantly associated with CF in the multivariate analysis, with the highest numerical point estimate for high neuroticism. Fatigue or loss of vitality, to a certain degree reflecting fatigue, has been reported in several surveys of prostate cancer survivors, [9][10][11][12][13] often assessed as a dimension of a generic QoL instrument such as the RAND 36-Item Health Survey (SF-36) or the EORTC QLQ C30. However, in most studies patients who never received ADT cannot be separated from those with previous or ongoing hormone treatment.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The prevalence of fatigue as a late adverse effect after treatment for localized prostate cancer is 15-40% after RAD 9-13 and 10-17% after RP. 9,10,13 However, there are differences in the definition of fatigue, followup time and heterogeneity of samples explaining the variation in prevalence figures. In particular, fatigue has rarely been studied in hormone-naïve prostate cancer survivors after RP and RAD, and no study has examined CF in such samples.…”

Section: Introductionmentioning

confidence: 99%

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Fatigue in hormone-naïve prostate cancer patients treated with radical prostatectomy or definitive radiotherapy

Kyrdalen

Dahl

Hernes

et al. 2010

Prostate Cancer Prostatic Dis

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Chronic fatigue (CF) is a distressing symptom that follows cancer treatment; however, it has rarely been studied in hormone-naïve prostate cancer survivors after radical prostatectomy (RP) or definitive radiotherapy (RAD). We investigated CF in prostate cancer survivors after RP or RAD as monotherapy and explored associations between CF and medical and psychosocial variables. A population-based, cross-sectional postal survey in 2006 included Norwegian hormone-naïve survivors with the diagnosis of prostate cancer in 2004 who were treated with RP (n ¼ 337) or RAD (n ¼ 184). The primary outcome variable was prevalence of CF (defined as fatigue lasting 6 months or longer). Twelve to 32 months after RP and RAD, 13.4 and 26.1% of the patients after, respectively, RP and RAD reported CF inversely associated with pretreatment age (P ¼ 0.003). In multivariate analysis, high neuroticism, post-treatment co-morbidity, pain, urinary and intestinal dysfunction, but not sexual dysfunction, were positively associated with reporting CF. Further studies of CF in prostate cancer survivors should take into consideration the survivors' pretreatment medical and psychosocial situation.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fatigue in hormone-naïve prostate cancer patients treated with radical prostatectomy or definitive radiotherapy

Kyrdalen

Dahl

Hernes

et al. 2010

Prostate Cancer Prostatic Dis

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“…The clinical impact of our findings might be somewhat limited since most of our toxicities were moderate ones (grade 2) althought even less intense late rectal reactions can bother patients quality of life and quality of function (Lilleby et al, 1999).…”

Section: Discussionmentioning

confidence: 83%

Adjuvant androgen deprivation impacts late rectal toxicity after conformal radiotherapy of prostate carcinoma

Sanguineti¹,

Agostinelli²,

Foppiano³

et al. 2002

Br J Cancer

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To evaluate whether androgen deprivation impacts late rectal toxicity in patients with localised prostate carcinoma treated with three-dimensional conformal radiotherapy. One hundred and eighty-two consecutive patients treated with 3DCRT between 1995 and 1999 at our Institution and with at least 12 months follow-up were analysed. three-dimensional conformal radiotherapy consisted in 70 -76 Gy delivered with a conformal 3-field arrangement to the prostate+seminal vesicles. As part of treatment, 117 patients (64%) received neo-adjuvant and concomitant androgen deprivation while 88 (48.4%) patients were continued on androgen deprivation at the end of three-dimensional conformal radiotherapy as well. Late rectal toxicity was graded according to the RTOG morbidity scoring scale. Median follow up is 25.8 (range: 12 -70.2 months). The 2-year actuarial likelihood of grade 2 -4 rectal toxicity was 21.8+3.2%. A multivariate analysis identified the use of adjuvant androgen deprivation (P=0.0196) along with the dose to the posterior wall of the rectum on the central axis (P=0.0055) and the grade of acute rectal toxicity (P=0.0172) as independent predictors of grade 2 -4 late rectal toxicity. The 2-year estimates of grade 2 -4 late rectal toxicity for patients receiving or not adjuvant hormonal treatment were 30.3+5.2% and 14.1+3.8%, respectively. Rectal tolerance is reduced in presence of adjuvant androgen deprivation.

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“…Prior studies have been mixed with regard to whether prostate-specific dysfunction is associated with general HRQOL. 19,20 Our findings suggest that Japanese men may be better prepared for the complications that may ensue from RP or BT. That is, their anticipation of longterm problems may ameliorate any negative psychological consequences by allowing coping strategies that are more culturally consonant.…”

Section: Discussionmentioning

confidence: 73%

Distress and social dysfunction following prostate cancer treatment: a longitudinal cross-cultural comparison of Japanese and American men

Namiki

Kwan

Kagawa‐Singer

et al. 2008

Prostate Cancer Prostatic Dis

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We assessed the impact of bother with urinary and bowel dysfunction on social activities among men in Japan and the United States following primary therapy for localized prostate cancer. In paired longitudinal outcomes studies, we measured general and disease-specific health-related quality of life in 400 Japanese and 427 American men who underwent radical prostatectomy or brachytherapy for localized prostate cancer. Outcomes included the social function domain of the Medical Outcomes Study Short Form-36 and the University of California, Los Angeles Prostate Cancer Index, all of which are scored 0-100. Participants completed the questionnaires before and 1, 12 and 24 months after treatment. Among men who reported any urinary bother, Japanese men had slightly better urinary function than American men (84 vs 77, Po0.01). Before brachytherapy, urinary bother was weakly correlated with social function in both the countries; after brachytherapy, urinary bother was strongly correlated with social function in American but not Japanese men. After brachytherapy, bowel dysfunction had a stronger correlation with social function in American than Japanese men (Po0.05). The bother associated with urinary and bowel dysfunction after surgery or brachytherapy for prostate cancer has a greater impact on social function in American men than in Japanese men.

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Long-term morbidity and quality of life in patients with localized prostate cancer undergoing definitive radiotherapy or radical prostatectomy

Cited by 172 publications

References 37 publications

Fatigue in hormone-naïve prostate cancer patients treated with radical prostatectomy or definitive radiotherapy

Fatigue in hormone-naïve prostate cancer patients treated with radical prostatectomy or definitive radiotherapy

Adjuvant androgen deprivation impacts late rectal toxicity after conformal radiotherapy of prostate carcinoma

Distress and social dysfunction following prostate cancer treatment: a longitudinal cross-cultural comparison of Japanese and American men

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