Long-term mortality and intestinal obstruction after laparoscopic cholecystectomy: A systematic review and meta-analysis

Jensen, Sofie Anne-Marie Skovbo; Fonnes, Siv; Gram-Hanssen, Anders; Andresen, Kristoffer; Rosenberg, Jacob

doi:10.1016/j.ijsu.2022.106841

Cited by 11 publications

(8 citation statements)

References 52 publications

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“…Nowadays, prompt treatment algorithm for gallstone-cholecystectomy is strongly recommended, to avoid amounts of severe biliary outcomes, of note acute cholecystitis, cholangitis, pancreatitis and even gallbladder cancer [1]. In addition, apart from binary complications, comorbidities and extra-biliary outcomes are drawn mounting attention [4]. Our results suggested that cholelithiasis and cholecystitis both increased the tendency of severe COVID-19, whereas cholecystectomy reduced the counterparts (Figure 3), though the statistic was not signi cant.…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, cholecystectomy, de ned as the gall bladder removal, has been widely perceived as the standard treatment for multiple gallbladder diseases, not least symptomatic cholelithiasis and cholecystitis [3]. With advanced technology, this surgical procedure can be successfully performed with little post-surgical complications [4]. Nonetheless, whether gallstone disorders or cholecystectomy directly in uences the quality of life or causally generates long-term detrimental impacts remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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No Causal Association Between Cholelithiasis and COVID-19: A Bidirectional Mendelian Randomization Study

Li,

Sun,

Shao

et al. 2023

Preprint

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Background: Gallstone diseases and cholecystectomy are possibly associated with the severity of COVID-19 bidirectionally, yet the casual association remains unclear. Method: Applying genome-wide association study summary statistics of primarily European individuals, we utilized 2-sample Mendelian randomization to estimate the bidirectional causal effects of cholelithiasis, cholecystitis and cholecystectomy on three COVID-19 phenotypes: SARS-CoV-2 infection, COVID-19 hospitalization and severe COVID-19. Results: Inverse variance weighted Mendelian randomization results from the FinnGen consortium showed that none of cholelithiasis, cholecystitis and cholecystectomy was not causally associated with COVID-19 phenotypes, and vice versa. In addition, other methods including MR-Egger, weighted median, weight mode and simple mode exhibited approximate tendency as IVW. These results were all robust to sensitivity analysis. Conclusion: The forward MR analysis showed no causally significant impact of cholelithiasis, cholecystitis and cholecystectomy on COVID-19 phenotypes. Similarly, reverse MR results also showed no causal association between COVID-19 and cholelithiasis events.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

No Causal Association Between Cholelithiasis and COVID-19: A Bidirectional Mendelian Randomization Study

Li,

Sun,

Shao

et al. 2023

Preprint

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“…The coexistence of these two conditions, known as multimorbidity, poses complex challenges for clinical management ( 3 ). For example, while laparoscopic cholecystectomy is the gold standard treatment for GSD ( 4 ), individuals with diabetes are usually high-risk candidates for any surgery. Therefore, it is imperative to comprehend the association between T2DM and GSD, as well as the underlying biological mechanisms, to ensure effective prevention and management of this multimorbidity.…”

Section: Introductionmentioning

confidence: 99%

Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease

Yan,

Zhang,

Yang

et al. 2024

Front. Endocrinol.

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BackgroundThe relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms underlying these associations.MethodsWe first evaluated the phenotypic association between T2DM and GSD using data from the UK Biobank (n>450,000) using a prospective observational design. We then conducted genetic analyses using summary statistics from a meta-analysis of genome-wide association studies of T2DM, with and without adjusting for body mass index (BMI) (Ncase=74,124, Ncontrol=824,006; T2DMadjBMI: Ncase=50,409, Ncontrol=523,897) and GSD (Ncase=43,639, Ncontrol=506,798).ResultsA unidirectional phenotypic association was observed, where individuals with T2DM exhibited a higher GSD risk (hazard ratio (HR)=1.39, P<0.001), but not in the reverse direction (GSD→T2DM: HR=1.00, P=0.912). The positive T2DM-GSD genetic correlation (rg=0.35, P=7.71×10-23) remained even after adjusting for BMI (T2DMadjBMI: rg=0.22, P=4.48×10-10). Mendelian randomization analyses provided evidence of a unidirectional causal relationship (T2DM→GSD: odds ratio (OR)=1.08, P=4.6×10-8; GSD→T2DM: OR=1.02, P=0.48), even after adjusting for important metabolic confounders (OR=1.02, P=0.02). This association was further corroborated through a comprehensive functional analysis reflected by 23 pleiotropic single nucleotide polymorphisms, as well as multiple neural and motor-enriched tissues.ConclusionThrough comprehensive observational and genetic analyses, our study clarified the causal relationship between T2DM and GSD, but not in the reverse direction. These findings might provide new insights into prevention and treatment strategies for T2DM and GSD.

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“…Cholelithiasis has become one of the most common diseases of the gallbladder [1][2][3]. As the development of the technology and biomedical developments, cholecystectomy can be treated with the laparoscopic method [4][5][6][7][8]. However, many patients undergoing laparoscopic cholecystectomy suffer from severe abdominal pain which was caused by surgical manipulation and peritoneal irritation due to CO2 gas dissolved in the abdomen [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Analgesic Efficacy of Foot and Hand Massage for Laparoscopic Cholecystectomy: A Meta-Analysis

Chen

Zhang

Wei

et al. 2023

Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

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Background Foot and hand massage may benefit to alleviate pain for laparoscopic cholecystectomy, and this meta-analysis is intended to study the influence of foot and hand massage on pain intensity after laparoscopic cholecystectomy. Methods We systematically searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases, and included randomized controlled trials (RCTs) assessing the effect of foot and hand massage on postoperative pain of laparoscopic cholecystectomy. Results Six RCTs and 663 patients were included in the meta-analysis. Compared with control intervention for laparoscopic cholecystectomy, massage intervention resulted in significantly decreased pain scores at 60 min (SMD=–0.73; 95% CI=–1.27 to –0.19; P=0.008), pain scores at 90 min (SMD=–0.80; 95% CI=–1.23 to –0.37; P=0.0003), pain scores at 120–150 min (SMD=–1.74; 95% CI=–1.96 to –1.52; P<0.00001) and the need of additional analgesia (OR=0.04; 95% CI=0.02 to 0.07; P<0.00001), but demonstrated no influence on pain scores at 10–30 min (SMD=–0.14; 95% CI=–0.39 to 0.12; P=0.29). Conclusions Foot and hand massage may be able to reduce pain intensity after laparoscopic cholecystectomy.

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Long-term mortality and intestinal obstruction after laparoscopic cholecystectomy: A systematic review and meta-analysis

Cited by 11 publications

References 52 publications

No Causal Association Between Cholelithiasis and COVID-19: A Bidirectional Mendelian Randomization Study

No Causal Association Between Cholelithiasis and COVID-19: A Bidirectional Mendelian Randomization Study

Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease

Analgesic Efficacy of Foot and Hand Massage for Laparoscopic Cholecystectomy: A Meta-Analysis

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