Long-term mortality of elderly patients after intensive care unit admission for COVID-19

Guillon, Antoine; Laurent, E.; Godillon, Lucile; Kimmoun, Antoine; Grammatico‐Guillon, Leslie

doi:10.1007/s00134-021-06399-x

Cited by 32 publications

(28 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only 1% of patients discharged died within the first year of follow-up. Mortality observed after hospital discharge was lower than that reported in other studies on COVID-19 [ 3 ]. When compared with other causes of pneumonia, long-term mortality related to COVID-19 is lower as well.…”

contrasting

confidence: 71%

One-year mortality after ICU admission due to COVID-19 infection

et al. 2022

View full text Add to dashboard Cite

contrasting

confidence: 71%

One-year mortality after ICU admission due to COVID-19 infection

et al. 2022

View full text Add to dashboard Cite

“…We found a strong association of age with mortality. This is, at least in part, in line with previous studies showing that age is a risk factor for mortality in invasively ventilated ICU patients in general [ 37 – 40 ], and in COVID–19 in particular [ 13 , 41 – 43 ]. After adjusting for comorbidities and other effect modifiers, mortality rates remained significantly higher in the older patients.…”

Section: Discussionsupporting

confidence: 90%

The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID study

Hol

Oosten

Nijbroek

et al. 2022

Aging

View full text Add to dashboard Cite

Introduction: We analyzed the association of age with ventilation practice and outcomes in critically ill COVID–19 patients requiring invasive ventilation. Methods: Posthoc analysis of the PRoVENT–COVID study, an observational study performed in 22 ICUs in the first 3 months of the national outbreak in the Netherlands. The coprimary endpoint was a set of ventilator parameters, including tidal volume normalized for predicted bodyweight, positive end–expiratory pressure, driving pressure, and respiratory system compliance in the first 4 days of invasive ventilation. Secondary endpoints were other ventilation parameters, the use of rescue therapies, pulmonary and extrapulmonary complications in the first 28 days in the ICU, hospital– and ICU stay, and mortality. Results: 1122 patients were divided into four groups based on age quartiles. No meaningful differences were found in ventilation parameters and in the use of rescue therapies for refractory hypoxemia in the first 4 days of invasive ventilation. Older patients received more often a tracheostomy, developed more frequently acute kidney injury and myocardial infarction, stayed longer in hospital and ICU, and had a higher mortality. Conclusions: In this cohort of invasively ventilated critically ill COVID–19 patients, age had no effect on ventilator management. Higher age was associated with more complications, longer length of stay in ICU and hospital and a higher mortality.

show abstract

“…Finally, two recently published large-scale studies by Guillon et al [ 32 ] and Dres et al [ 33 ], the latter focusing exclusively on elderly patients over 70 years old, demonstrated similar results with reported mortality rates 38.7% in patients ≥ 65 years and 45.8% in patients ≥ 70 years, respectively. Moreover, both studies showed that elderly patients over 80 years old were remarkably more susceptible to death (62.5% and 66.8%) compared to young- and middle-old patients.…”

Section: Resultssupporting

confidence: 68%

“…Thus, we included those studies that provided separate data for elderly patients, as a subgroup, in the analyses of the whole study ICU population with COVID-19. However, during the revision process of the present review article, two additional studies have been recently released; therefore they have been added to the present review[ 32 , 33 ].…”

Section: Methodsmentioning

confidence: 99%

Elderly adults with COVID-19 admitted to intensive care unit: A narrative review

Gkoufa¹,

Maneta²,

Ntoumas³

et al. 2021

wjccm

View full text Add to dashboard Cite

BACKGROUND In the context of the Coronavirus disease 2019 (COVID-19) pandemic, it has been reported that elderly patients are particularly at risk of developing severe illness and exhibiting increased mortality. While many studies on hospitalized elderly patients with COVID-19 have been published, limited information is available on the characteristics and clinical outcomes of those elderly patients admitted to intensive care unit (ICU). AIM To review the available evidence of the clinical data of elderly patients admitted to the ICU due to COVID-19. METHODS We searched for published articles available in English literature to identify those studies conducted in critically ill patients admitted to the ICU due to COVID-19, either exclusively designed for the elderly or for the whole ICU population with COVID-19, provided that analyses according to the patients’ age had been conducted. RESULTS Only one study exclusively focusing on critically ill elderly patients admitted to the ICU due to COVID-19 was found. Eighteen additional studies involving 17011 ICU patients and providing information for elderly patients as a subset of the whole study population have also been included in the present review article. Among the whole patient population, included in these studies, 8310 patients were older than 65 years of age and 2630 patients were older than 70 years. Clinical manifestations were similar for all patients; however, compared to younger ones, they suffered from more comorbidities and showed a varied, albeit high mortality. CONCLUSION In summary, at present, although elderly patients constitute a considerable proportion of critically ill patients admitted to the ICU due to severe COVID-19, studies providing specific information are limited. The evidence so far suggests that advanced age and comorbidities are associated with worse clinical outcome. Future studies exclusively designed for this vulnerable group are needed.

show abstract

Long-term mortality of elderly patients after intensive care unit admission for COVID-19

Cited by 32 publications

References 5 publications

One-year mortality after ICU admission due to COVID-19 infection

One-year mortality after ICU admission due to COVID-19 infection

The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID study

Elderly adults with COVID-19 admitted to intensive care unit: A narrative review

Contact Info

Product

Resources

About