Long-term negative pressure wound therapy decreases a risk of diabetic foot amputation assessed in the university of Texas wound classification

Diabetic foot salvage: breaking paradigms through a case report

“…Similarly, Lavery et al (5) compared the efficacy of NPWT+saline irrigation with that of NPWT+polyhexanide-betaine 0.1% irrigation in patients with infected DF, finding that the latter did not demonstrate significant improvements in wound healing relative to saline. In our case, NPWT was applied for four weeks and, then, we proceeded to ambulatory healing for approximately ten months-these periods have been the subject of multiple studies, such as the one described by Węgrzynowski et al (6) , who evaluated NPWT for "extended time" (±4 weeks) in patients with DF and observed a significant decrease of 92% in the risk of amputation compared to that seen in the short-time NPWT group. The abovementioned study also highlights the importance of microbial control in DF lesions, describing the lack of any benefit from the use of NPWT in infected ischemic lesions or active sepsis.…”

“…This was initially managed in two stages, in-hospital and outof-hospital-the first one basically for surgical cleaning, stabilization of the internal environment, intravenous antibiotic therapy, and use of NPWT, while the second phase was exclusively focused on daily outpatient dressings and maintenance of DM2 management measures. This whole process has been almost systematically established as a part of the DF salvage protocol and is now a therapeutic model that has been progressively implemented in major healthcare institutions nationwide (5,6,9) .…”