Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes

Kramer, Morton; Chiu, C.-Y. Peter; Walz, Nicolay Chertkoff; Holland, Scott K.; Yuan, Weihong; Karunanayaka, Prasanna; Wade, Shari L.

doi:10.1017/s1355617708080545

Cited by 49 publications

(43 citation statements)

References 54 publications

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“…21 This developmental effect occurs despite the generally larger capacity for plasticity and repair in younger brains but may be secondary to the disruption of neurodevelopmental processes. 22,23 The dopamine system is positioned to serve as a key mediator of TBI-induced alterations in reward processing. Dopaminergic agonists have shown some clinical efficacy in alleviating cognitive and mood dysfunction following TBI.…”

Section: Weil Et Almentioning

confidence: 99%

Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

Weil

Karelina

Gaier

et al. 2016

Journal of Neurotrauma

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Traumatic brain injury (TBI) is closely and bi-directionally linked with alcohol use, as by some estimates intoxication is the direct or indirect cause of one-third to one-half of all TBI cases. Alcohol use following injury can reduce the efficacy of rehabilitation and increase the chances for additional injury. Finally, TBI itself may be a risk factor for the development of alcohol use disorders. Children who suffer TBIs have poorer life outcomes and more risk of substance abuse. We used a standardized closed-head injury to model mild traumatic brain injuries. We found that mice injured as juveniles but not during adulthood exhibited much greater alcohol self-administration in adulthood. Further, this phenomenon was limited to female mice. Using behavioral testing, including conditioned place preference assays, we showed that early injuries increase the rewarding properties of alcohol. Environmental enrichment administered after injury reduced axonal degeneration and prevented the increase in drinking behavior. Additionally, brain-derived neurotrophic factor gene expression, which was reduced by TBI, was normalized by environmental enrichment. Together, these results suggest a novel model of alterations in reward circuitry following trauma during development.

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Section: Weil Et Almentioning

confidence: 99%

Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

Weil

Karelina

Gaier

et al. 2016

Journal of Neurotrauma

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“…The few fMRI studies examining cognitive function following TBI in children and adolescents have primarily focused on more severely injured patients (Cazalis et al, 2011;Karunanayaka et al, 2007;Kramer et al, 2009Kramer et al, ,2008Newsome et al, 2007Newsome et al, ,2008Tlustos et al, 2011;Wilde et al, 2011), with only two studies focusing on a well-defined mTBI population (Krivitzky et al, 2011;Talavage et al, 2010). Krivitzky and colleagues (2011) reported no difference in brain activation between children with mTBI and healthy controls (HCs) on a working memory task, but they found hyperactivation in mTBI patients in the posterior cerebellum with the addition of a demand for inhibitory control processes.…”

Section: Introductionmentioning

confidence: 99%

An fMRI Study of Auditory Orienting and Inhibition of Return in Pediatric Mild Traumatic Brain Injury

Yang

Yeo

Peña

et al. 2012

Journal of Neurotrauma

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Studies in adult mild traumatic brain injury (mTBI) have shown that two key measures of attention, spatial reorienting and inhibition of return (IOR), are impaired during the first few weeks of injury. However, it is currently unknown whether similar deficits exist following pediatric mTBI. The current study used functional magnetic resonance imaging (fMRI) to investigate the effects of semi-acute mTBI ( < 3 weeks post-injury) on auditory orienting in 14 pediatric mTBI patients (age 13.50 -1.83 years; education: 6.86 -1.88 years), and 14 healthy controls (age 13.29 -2.09 years; education: 7.21 -2.08 years), matched for age and years of education. The results indicated that patients with mTBI showed subtle (i.e., moderate effect sizes) but non-significant deficits on formal neuropsychological testing and during IOR. In contrast, functional imaging results indicated that patients with mTBI demonstrated significantly decreased activation within the bilateral posterior cingulate gyrus, thalamus, basal ganglia, midbrain nuclei, and cerebellum. The spatial topography of hypoactivation was very similar to our previous study in adults, suggesting that subcortical structures may be particularly affected by the initial biomechanical forces in mTBI. Current results also suggest that fMRI may be a more sensitive tool for identifying semi-acute effects of mTBI than the procedures currently used in clinical practice, such as neuropsychological testing and structural scans. fMRI findings could potentially serve as a biomarker for measuring the subtle injury caused by mTBI, and documenting the course of recovery.

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“…In a follow-up study conducted 1 year after the injury, Kramer et al (2008) a group with CTBI and a control group with orthopaedic injuries activated similar networks relevant to sustained attention processing, but the group with CTBI showed a neural over-activation in these areas. The results for the group with CTBI contrasted with the under-activation documented in studies of children with attention-deficit/hyperactivity disorder, commonly referred to as ADHD (Kramer et al, 2008). Levin et al (2007) investigated changes in children"s symptoms related to inattention and hyperactivity 2 years after CTBI.…”

Section: Early Cognitive Outcomementioning

confidence: 97%

Long-term cognitive outcome of childhood traumatic brain injury

Jonsson¹

2010

PsycEXTRA Dataset

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There is limited knowledge of cognitive outcome extending beyond 5 years after childhood traumatic brain injury, CTBI. The main objectives of this thesis were to investigate cognitive outcome at 6 14 years after CTBI, and to evaluate if advancements in the neurosurgical care, starting 1992, did influence long-term outcome and early epidemiology. An additional aim was to study the relationship between early brain injury parameters and early functional outcome. Study 1 evaluated cognitive progress during 14 years after CTBI, over three neuropsychological assessments in 8 patients with serious CTBI. Study 2 used patient records to investigate early epidemiology, received rehabilitation and medical follow up in two clinical cohorts, n=82 and n=46, treated neurosurgically for CTBI before and after 1992. An exploratory cluster analysis was applied to analyse the relation between early brain injury severity parameters and early functional outcome. In Study 3, participants in the two cohorts, n=18 and n=23, treated neurosurgically for CTBI before and after 1992, were subject to an extensive neuropsychological assessment, 13 and 6 years after injury, respectively. Assessment results of the two cohorts were compared with each other and with controls. Data were analysed with multivariate analyses of variance. Results and discussion. There were significant long-term cognitive deficits of similar magnitude and character in the two cohorts with CTBI, treated before and after the advancements in neurosurgical care. At 6 14 years after injury, long-term deficits in verbal intellectual and executive functions were found, and were discussed in terms of their late maturation and a decreased executive control over verbal memory-functions after CTBI. Visuospatial functions had a slightly better long-term recovery. The amount of rehabilitation received was equally low in both cohorts. The length of time spent in intensive care and the duration of care in the respirator may have a stronger relationship to early outcome than does a single measure of level of consciousness at admission. Main conclusions are that cognitive deficits are apparent at longterm follow up, 6 13 years after neurosurgically treated CTBI, even after advancements in the neurosurgical care in Sweden. Measures of verbal IQ, verbal memory and executive functions were especially low while visuospatial intellectual functions appear to have a better long-term recovery.

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Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes

Cited by 49 publications

References 54 publications

Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

Juvenile Traumatic Brain Injury Increases Alcohol Consumption and Reward in Female Mice

An fMRI Study of Auditory Orienting and Inhibition of Return in Pediatric Mild Traumatic Brain Injury

Long-term cognitive outcome of childhood traumatic brain injury

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