Long-term neurologic outcome in children with opsoclonus-myoclonus associated with neuroblastoma: A report from the Pediatric Oncology Group

Russo, Carolyn; Cohn, Susan L.; Petruzzi, Mary Jane; Alarcón, Pedro A. de

doi:10.1002/(sici)1096-911x(199704)28:4<284::aid-mpo7>3.0.co;2-e

Cited by 162 publications

(99 citation statements)

References 13 publications

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“…Ig, but residual central nervous system signs are frequent [59,63,73]. Treatment of the tumor with chemotherapy is the most important predictor of good neurological recovery [74].…”

Section: Treatment and Prognosismentioning

confidence: 99%

Managing Paraneoplastic Neurological Disorders

2006

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“…Ig, but residual central nervous system signs are frequent [59,63,73]. Treatment of the tumor with chemotherapy is the most important predictor of good neurological recovery [74].…”

Section: Treatment and Prognosismentioning

confidence: 99%

Managing Paraneoplastic Neurological Disorders

2006

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“…These paraneoplastic manifestations have an immunologic basis and are associated with IgG and IgM antibodies that bind to the cytoplasm of cerebellar Purkinje's cells and to some axons of the peripheral nerves [157]. In one patient with occult neuroblastoma, encephalitis-like features of ataxia, generalized seizures, decreased consciousness, and involuntary movements were seen; however, this patient did not have any signs of opsoclonus-myoclonus at any time during his illness [158].…”

Section: Emergency Conditions Related To Neuroblastomamentioning

confidence: 99%

Emergencies Caused by Pheochromocytoma, Neuroblastoma, or Ganglioneuroma

Brouwers

Eisenhofer

Lenders

et al. 2006

Endocrinology and Metabolism Clinics of North America

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This article reviews emergency situations caused by diseases of the sympathetic nervous system. Pheochromocytoma is discussed first and most extensively, because there are numerous reports in the literature on patients with (unsuspected) pheochromocytoma presenting as an emergency. Two other tumors of the sympathetic nervous system are then discussed that less commonly result in endocrine emergencies: neuroblastoma and ganglioneuroma. PheochromocytomaParagangliomas are rare catecholamine-producing tumors derived from chromaffin cells that can be fatal if left undiagnosed.

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“…Although autopsy has been inconclusive in the localization of the specific area affected by this syndrome, autoimmune destruction of Purkinje cells, dentate demyelination, and damage to the cerebellum and brainstem have all been implicated in the pathophysiology of OMS (6). Finally, a retrospective chart review of children conducted by Russo et al aimed at addressing the long-term neurological outcome of patients who develop OMS found that 18 of 29 (62%) experienced a complete recovery, as was seen in our patient (7).…”

Section: Discussionmentioning

confidence: 99%