Long-term neuropsychological outcome of closed head injury

Levin, Harvey S.; Grossman, Robert G.; Rose, James E.; Teasdale, Graham M.

doi:10.3171/jns.1979.50.4.0412

Cited by 314 publications

(85 citation statements)

References 19 publications

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“…Alternative methods for measuring therapeutic benefit within this lower end of the ability spectrum, such as neurobehavioral rating scales, will be preferable. 95 Whereas cognitive impairment remains detectable many years after severe TBI, [13][14][15]19 impairment is no longer detectable at the group level by 3 months after a mild TBI in most controlled studies. 11 There is a debate in the literature as to whether neuropsychological tests are inadequately sensitive to detect subtle deficits in post-acute mild TBI (i.e., the tests are too imprecise to detect the signal) or whether mild TBI does not result in lasting neurocognitive impairment (i.e., there is no signal to detect).…”

Section: Limitations Of Cognition Endpointmentioning

confidence: 99%

“…12 The risk of persistent or permanent cognitive impairment increases with the severity of injury. [9][10][11][13][14][15] Patient characteristics such as age further modify the recovery curve. [16][17][18][19] Cognition is associated with functional outcome in most studies, as measured by rehabilitation gains, functional independence, community reintegration, and employment.…”

Section: Introductionmentioning

confidence: 99%

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Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials

Silverberg

Crane

Dams-O’Connor

et al. 2017

Journal of Neurotrauma

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Cognitive impairment is a core clinical feature of traumatic brain injury (TBI). After TBI, cognition is a key determinant of post-injury productivity, outcome, and quality of life. As a final common pathway of diverse molecular and microstructural TBI mechanisms, cognition is an ideal endpoint in clinical trials involving many candidate drugs and nonpharmacological interventions. Cognition can be reliably measured with performance-based neuropsychological tests that have greater granularity than crude rating scales, such as the Glasgow Outcome Scale-Extended, which remain the standard for clinical trials. Remarkably, however, there is no well-defined, widely accepted, and validated cognition endpoint for TBI clinical trials. A single cognition endpoint that has excellent measurement precision across a wide functional range and is sensitive to the detection of small improvements (and declines) in cognitive functioning would enhance the power and precision of TBI clinical trials and accelerate drug development research. We outline methodologies for deriving a cognition composite score and a research program for validation. Finally, we discuss regulatory issues and the limitations of a cognition endpoint.

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Section: Limitations Of Cognition Endpointmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials

Silverberg

Crane

Dams-O’Connor

et al. 2017

Journal of Neurotrauma

View full text Add to dashboard Cite

show abstract

“…Memory is the cognitive part that is usually impaired in a traumatic brain injury patient, and this impairment may persist for several years [1]. Many batteries exist to evaluate neuropsychological and neurophysiological tests among TBI patients, such as MMSE, WAIS-R, and SDS, which are thought to reflect the cognitive processes of memory function, intelligence, and affective disorders neuropsychologically.…”

Section: (Text)mentioning

confidence: 99%

Correlations between neuropsychological test results and P300 latency during silent-count and button-press tasks in post-traumatic brain injury patients

Reza

Ikoma

Chuma

et al. 2006

Journal of Clinical Neuroscience

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Abstract:To evaluate the correlations between memory function and intelligence and event-related potential, the P300 component for different tasks was studied for 30 post-traumatic brain injury patients (mean age 31.6 ± 13.7 years; 23 male and 7 female). Memory function, intelligence, and depression were measured by using the Mini-Mental State Examination, the revised Wechsler Adult Intelligence Scale and the Self-Rating Depression Scale, respectively. P300 latency was measured during silent-count and button-press tests at three midline scalp (Fz, Cz, and Pz) sites for all subjects by using an auditory 'odd-ball' paradigm. Neuropsychological memory score was predicted by intelligence score, but neurophysiological P300 latency was predicted by memory score for the silent-count test and by intelligence score for the button-press test. These results show that the P300 event-related potential component is sensitive to the diverse nature of cognitive deficits in post-traumatic brain injury patients during different types of discrimination tasks.However, future research is necessary to replicate and extend these findings.

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“…Individuals who sustained a traumatic brain injury often experienced a combination of physical, cognitive, emotional and behavior symptoms in the days or weeks after injury 38,39) . In more severe cases, intellectual impairment and executive dysfunction were observed 40,41) . Therefore, intracranial injuries in our study workers affected the coping skills required to handle the psychological distress 42) .…”

Section: Discussionmentioning

confidence: 99%

Psychological Outcome of Injured Workers at 3 Months after Occupational Injury Requiring Hospitalization in Taiwan

Lin

Guo

Liao

et al. 2012

Journal of Occupational Health

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Kuan-Han LIN, et al.: Psychological Outcome after Occupational Injury among workers who suffered from intracranial injury, fracture, burn, crushing injury, and open wound of upper limbs were 10.4, 6.9, 5.9, 5.8 and 0%, respectively. Conclusions: At three months after occupational injuries, a significant proportion of workers suffered from psychiatric disorders. The rates of psychiatric disorders occurring after intracranial injuries were significantly higher than those occurring after non-intracranial injuries. ( . According to the Institute of Occupational Safety and Health in Taiwan in 2004, occupational accidents were the 2nd most important cause of death among workers 2) . Occupational injury is defined as death, any personal injury or disease resulting from an occupational accident 3) . According to the Bureau of Labor Insurance, there are three types of medical benefits for occupational injury, including inpatient benefits, outpatient benefits, and medical examination benefits. In 2008, of the workers who received medical benefits for occupational injury, more than 14,000 workers received inpatient benefits due to occupational injuries 4) . Traumatic events or natural disasters are known to induce psychiatric disorders, including post-traumatic stress disorder (PTSD), major depression, anxiety, etc. [5][6][7] . PTSD is the most commonly studied and probably the most frequent psychological disorder that

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Long-term neuropsychological outcome of closed head injury

Cited by 314 publications

References 19 publications

Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials

Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials

Correlations between neuropsychological test results and P300 latency during silent-count and button-press tasks in post-traumatic brain injury patients

Psychological Outcome of Injured Workers at 3 Months after Occupational Injury Requiring Hospitalization in Taiwan

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