Long Term Observation of the Growth Promoting Action of Human Chorionic Gonadotrophin

Reiß, M.; Hillman, Janet; Pearse, J; Reiss, Jean M.; Daley, N; Suwalski, R.

doi:10.1530/acta.0.0490349

Cited by 4 publications

(3 citation statements)

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“…We are particularly encouraged by our finding that in all five patients treated over a period of three to four weeks with HCG fasting plasma HGH levels were unequivocally increased, supporting our original assumption (Reiss, et al, 1965a;Reiss, 196.5;Reiss, Sideman and Plichta, 1965b) that the growth promoting action of HGG is mediated through a stimulation of endogenous HGH production.…”

Section: Changes In Plasma Hgh Levels After a Single Hcg Injection Ansupporting

confidence: 63%

“…These compounds may even reduce the 17-keteosteroid excretion rate but they increase blood alkaline phosphatase levels, as HGH does (Reiss, 1965). The lack of any evidence of premature epiphyseal closure after HGG treatment in our patients would seem to support this assumption; longitudinal growth continued long after HGG treatment was completed (Reiss, et al, 1965a).…”

Section: Changes In Plasma Hgh Levels After a Single Hcg Injection Anmentioning

confidence: 58%

“…

We have studied the growth patterns of young physically and mentally retarded males for a numher of years and have deserihed such children and the effect of treatment with human ehorionic gonadotrophin (HCG) on their growth rate, sexual development and urinary steroid excretion rate (Reiss, Hillman and Davis, 1963;Reiss, Hillman, Pearse, Reiss, Daley and Suwalski, 1965a). We have expressed the opinion that the growth spurt produced in many of these hoys hy the gonadotrophin treatment was brought ahout hy an increased secretion of growth hormone (HGH) hy the pituitary, triggered most prohahly hy a rise in steroid production, hut it is only during the last three years, since the establishment of a relial)le radioimmunoassay technique in our lahoratory, that we have heen ahle to measure the level of growth hormone in the hlood of our patients.

…”

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confidence: 99%

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Changes in Plasma Growth Hormone Levels in Retarded Children

Hillman

Hammond

et al. 1968

J intellect Disabil Res

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Section: Changes In Plasma Hgh Levels After a Single Hcg Injection Ansupporting

confidence: 63%

Section: Changes In Plasma Hgh Levels After a Single Hcg Injection Anmentioning

confidence: 58%

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confidence: 99%

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Changes in Plasma Growth Hormone Levels in Retarded Children

Hillman

Hammond

et al. 1968

J intellect Disabil Res

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Lack of Difference in Growth Stimulating Effect Between Weekly Single and Multiple Human Chorionic Gonadotrophin Administration in Boys With Delayed Puberty

Bosch

Smals

Valk

et al. 1982

Clinical Endocrinology

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SUMMARYUsing a non‐invasive sensitive technique measuring ulnar length, short‐term growth was studied in two groups of boys with constitutional delay in growth. In one (group A) a protocol of multiple hCG injections weekly was used (3 × 1500 iu), whereas the other (group B) received a single dose of hCG weekly (1 × 1500 iu), both during 6 weeks. The two hCG protocols appeared to be equally potent in stimulating 3‐week Ulnar Growth rates (TUG‐rates), tripling the growth velocities from prepubertal to pubertal levels. After stopping hCG treatment the mean TUG‐rate decreased again to a post‐treatment level that, taking both groups together, was significantly higher than the mean pretreatment TUG‐rate. During hCG administration mean body growth rates also rose significantly in the two groups. The extent of the changes, however, only allowed evaluation for the whole group in contrast to the changes in TUG‐rates which far exceeded the limits of confidence in all but one boy. Serum alkaline phosphatase activities (APA) increased significantly during hCG treatment and almost paralleled the increase in TUG‐rates. The APA response (ΔAPA) in group A, however, was unexpectedly higher than in group B. After stopping hCG treatment the mean APA significantly decreased taking both groups together to an almost pretreatment level. The results showed that a weekly single dose hCG regimen was as effective as the weekly multiple injection protocol in stimulating TUG‐rates to pubertal levels in the groups of constitutionally delayed boys studied.

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Influence of Anabolic Hormones on Phenylalanine Metabolism:

Reiß¹,

Jc²,

Reiss³

et al. 1966

J intellect Disabil Res

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In the preceding communication, Reiss, Hillman, Reiss, Daley and Haylock (1966) the influence of anabolic steroids on the blood phenylalanine level of chronic phenylketonuric patients was reported. It was hoped to reach a better understanding of the various changes observed by further investigations carried out on animals.This study involved : (1) changes in the blood phenylalanine concentration in rabbits after intraperitoneal injection of phenylalanine and the influence of anabolic hormones on these changes; (2) the influence of anabolic hormones on the blood, brain and liver phenylalanine and tyrosine content of phenylalanine-fed rats and (3) the phenylalanine hydroxylase activity of the liver of the phenylalanine-fed animals with and without treatment with anabolic steroids. MATERIALWhite New Zealand rabbits weighing from 2.2 kg. to 2.7 kg. were used, litter-mates of the same sex being taken for each experiment. Sprague-Dawley rats from our own colony were 17 to 20 days of age when placed on experiment.The basic diet fed to the rats, both control and experimental animals, consisted of ground Purina Labchow with 18% Starlac powdered milk and 8.7% Mazola corn oil, as described by Yuwiler, et al. (1965).The diet fed to the experimental animals was supplemented with 6% 1-phenylalanine and 2% d-phenylalanine. Food and water were available ad libitum. PREPARATIONSWY-4071 (Wyeth Laboratories) dl-13-ethyl-17/8-hydroxygon-4-en-3-one decanoate, a long acting slowly absorbed anabolic steroid. Bovine growth hormone. Lot B-9, supplied by the Endocrinology Study section of National Institute of Health.* * In a biological assay on rat uterus it was found that 1.0 mg. ol this preparation contained 0.02 i.u. of oxytocin. In order to exclude the possibility that this oxytocin contamination could be reponsible for the action of intravenously injected growth hormone, as described in Table I, control experiments were carried out using 1.0 i.u. of oxytocin. No reduction in the plasma phenylalanine content was observed.

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Long Term Observation of the Growth Promoting Action of Human Chorionic Gonadotrophin

Cited by 4 publications

References 0 publications

Changes in Plasma Growth Hormone Levels in Retarded Children

Changes in Plasma Growth Hormone Levels in Retarded Children

Lack of Difference in Growth Stimulating Effect Between Weekly Single and Multiple Human Chorionic Gonadotrophin Administration in Boys With Delayed Puberty

Influence of Anabolic Hormones on Phenylalanine Metabolism:

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