Long-Term Observation of the Vitreomacular Relationship in Normal Fellow Eyes of Patients with Unilateral Idiopathic Macular Holes

Otsuji, Futoshi; Uemura, Akinori; Nakano, Tetsuro; Sakamoto, Taiji

doi:10.1159/000362460

Cited by 4 publications

(7 citation statements)

References 22 publications

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“…Chan et al [8] in 2004 and Takahashi et al [10] in 2011 found rates of evolution towards MH of 42 and 12%, respectively. In another TD-OCT study, Otsuji et al [13] reported a 13.8% incidence of MH occurring in fellow eyes with persistent vitreomacular attachment, with a follow-up duration similar to that in our series. These studies were conducted with TD-OCT analysis of the vitreomacular interface, and if the distinction between PVD stages was well performed, the distinction between VMA, a physiological stage of perifoveal PVD, and abnormal vitreofoveal attachment such as VMT was not explicit.…”

Section: Discussionsupporting

confidence: 87%

“…Nevertheless, among the 18 fellow eyes followed up for less than 1 year, PVD or MH occurred in 12 eyes: 8/9 eyes with VMT at baseline and 4/9 eyes without VMT. Moreover, the follow-up interval was similar to that reported in previous reports [13]. Thirdly, we excluded 55 eyes because their vitreofoveal status could not be defined.…”

Section: Discussionmentioning

confidence: 89%

“…However, with 77 patients included, this is one of the two largest series of MH in fellow eyes without PVD at baseline [13]. Secondly, the follow-up intervals between SD-OCT examinations varied between patients because of the retrospective design of this study, and some follow-ups were limited to 6 months, which could have led to an underestimation of the occurrence of MH in fellow eyes.…”

Section: Discussionmentioning

confidence: 99%

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Incidence of Macular Holes in the Fellow Eye without Vitreomacular Detachment at Baseline

Philippakis¹,

Astroz²,

Tadayoni³

et al. 2018

Ophthalmologica

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Purpose: To determine the rate of macular holes (MH) occurring in the fellow eyes of eyes with MH depending on the vitreomacular interface at baseline. Methods: This was a retrospective study of patients operated on for idiopathic MH, with persistent vitreofoveal attachment in the fellow eye assessed by spectral-domain optical coherence tomography (SD-OCT). Follow-up lasted 6 months or more, and the main outcome was the occurrence of an MH. Results: The 77 fellow eyes included had a mean follow-up of 34.11 ± 22.3 months (6–78.4). At baseline, 31 eyes had vitreomacular traction (VMT), 35 vitreomacular adhesion, and 11 no posterior vitreous detachment. MH occurred in 19.5% of the cases (15/77). The rate of MH was significantly higher among the eyes with VMT than among the eyes without VMT at baseline (35.5 vs. 8.7%; p = 0.009). Conclusion: One-third of eyes with VMT at baseline identified by SD-OCT will develop an MH in the following 5 years.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Incidence of Macular Holes in the Fellow Eye without Vitreomacular Detachment at Baseline

Philippakis¹,

Astroz²,

Tadayoni³

et al. 2018

Ophthalmologica

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“…SD-OCT based studies also showed that fellow eyes of patients with VMT or FTMH are at increased risk of developing VMI disorders. 34,35,36,37 It is important to examine the fellow eye and follow up with OCT. In our study, 8 of 12 patients had VMI disorders such as VMT, FTMH, and ERM.…”

Section: Discussionmentioning

confidence: 99%

Pneumatic Vitreolysis for the Treatment of Vitreomacular Traction Syndrome

Özdemir¹,

Özdek²,

Hasanreisoğlu³

2019

tjo

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Objectives:To evaluate the posterior vitreous release rates after a single injection of expansile gas in patients with vitreomacular traction (VMT) syndrome with or without associated full-thickness macular hole (FTMH).Materials and Methods:Thirteen eyes of 12 consecutive patients with VMT (11 eyes) or VMT+FTMH (2 eyes) were reviewed retrospectively. Intravitreal injection of 0.3 mL of pure sulfur hexafluoride (SF6) (9 eyes) or perfluoropropane (C3F8) (4 eyes) was performed. Bobbing the head forward and backward similar to ‘drinking bird’ head movements was instructed until VMT release. Full ophthalmic examination and optical coherence tomography was performed at each visit.Results:VMT was released in all patients (100%) and mean release time was 5.2 days (1-19 days). Macular hole closure was not achieved in either of the two eyes with FTMH. Mean central subfield thickness decreased significantly from 361 μm to 263 μm (p=0.007). The mean pretreatment visual acuity was 0.44 LogMAR, which significantly improved to 0.25 LogMAR at the last visit (p=0.003). One of 13 eyes had retinal tear after the procedure which was successfully treated with laser retinopexy. Gas migration to the anterior chamber occurred in one patient. No other complications were observed.Conclusion:Pneumatic vitreolysis with C3F8 and SF6 gases is a relatively safe, low-cost, and minimally invasive treatment modality for VMT. However, FTMH closure could not be achieved with pneumatic vitreolysis.

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“…Previous longitudinal studies of PVD stage in fellow eyes of macular holes demonstrated that partial PVD Stages 1 and 2 (termed vitreomacular adhesion) progress to Stages 3 and 4 (termed vitreomacular separation). 7–9 Our longitudinal data demonstrate the geographical progression of partial PVD from Stage 0 to 1, 1 to 2, 2 to 3, and 3 to 4. In contrast to the expected course, we found one eye which appeared to progress from Stage 1 to Stage 0 over 4 visits, and another eye which increased in VMAA over time at each of 2 follow-up visits.…”

Section: Discussionmentioning

confidence: 66%

Progression of Partial Posterior Vitreous Detachment Over Time

Koller

Kraker²,

Hwang³

2021

Retina

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Purpose: We investigated interindividual differences in the rate of change of posterior vitreous detachment (PVD) stage and vitreomacular adhesion area (VMAA). Crosssectional studies demonstrated increasing PVD stage and decreasing VMAA with age, but population-level means may mask interindividual variation in the rate of change.Methods: We retrospectively evaluated PVD stage and VMAA in asymptomatic eyes of subjects who underwent repeated optical coherence tomography screening for high-risk medication use or isolated retinal disease in the fellow eye. A Turnbull estimator modeled changes in the PVD stage, and linear mixed models evaluated VMAA change.Results: We evaluated 101 eyes of 101 subjects. Seventy-six eyes remained in the same stage. Twenty-three eyes progressed to a higher stage. Modeling of longitudinal data predicts that at age 30, time to convert to Stage 4 is 26 years; at age 40, it is 16 years; at age 50, it is 9 years; and at age 60, it is 8 years. In 37 eyes with Stage 1 partial PVD, VMAA decreased at a similar rate. The average population level decline in VMAA was 0.13 mm 2 /year.Conclusion: Individuals vary in age at which they progress to complete PVD. In early partial PVD, VMAA decreases at a similar rate across individuals.

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Long-Term Observation of the Vitreomacular Relationship in Normal Fellow Eyes of Patients with Unilateral Idiopathic Macular Holes

Cited by 4 publications

References 22 publications

Incidence of Macular Holes in the Fellow Eye without Vitreomacular Detachment at Baseline

Incidence of Macular Holes in the Fellow Eye without Vitreomacular Detachment at Baseline

Pneumatic Vitreolysis for the Treatment of Vitreomacular Traction Syndrome

Progression of Partial Posterior Vitreous Detachment Over Time

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