Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern

Ko, Kyung Rae; Lee, Sang Cheol; Oh, Seo Yoon; Kim, Ki-duk; Park, Sin Hyung; Lee, Soonchul

doi:10.2147/ppa.s266697

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…[3,4] Given the chronic nature and prolonged treatment required for this disease, https://doi.org/10.11005/jbm.2024.31.1.63 drug compliance is essential for successful treatment. [5] However, adherence to osteoporosis medications is known to be suboptimal, varying from 34% to 75% in the first year of treatment [6,7] and persistence levels at 1 year were reported to be between 18% and 75%. [8] This suboptimal adherence and persistence not only lead to increased fracture rate but also result in worse health outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…[9,10] Therefore, research aimed at improving compliance must be prioritized. [5] Various factors including dosing requirements, medical insurance impediments, medication, costs, side-effects of medications, and patient-physician rapport are mentioned, [11,12] but their effect on compliance is not fully understood. Recently, patient perception has been found to predict adherence to medication in a variety of chronic conditions [13] including osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

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Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis

Lee,

Lee

et al. 2024

J Bone Metab

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Background: Patient perception is a key element in improving compliance with medications for osteoporosis. This study evaluated the awareness, perception, sources of information, and knowledge of osteoporosis among Korean women with osteoporosis.Methods: A questionnaire survey was conducted from July 22, 2021 to 13 August 2021. Patients who were followed up in endocrinology (Endo), orthopedic surgery (OS), and gynecology (GY) were recruited (N=40, 40, and 20 in each group). Patients were allocated according to their age, as follows: 15, 15, and 10 patients in their 60s, 70s, and 80s for Endo and OS, and 10 and 10 patients in their 60s and 70s for GY. The questionnaire was composed of the following topics: patient journey to the hospital, drug-related issues, communication with medical doctors, patient knowledge, and sources of information about osteoporosis.Results: The results of medical check-ups were the most common reason for patient visits to the hospital for an initial diagnosis of osteoporosis (61%). A knowledge gap regarding mortality, refracture, and drug-induced osteoporosis was observed. Doctors were the most preferred and trustful source of information, while health-related TV shows were the second most common source of information. Patients with OS reported lower perceived severity and higher drug discontinuation, along with a higher proportion of fractures, as the initial reasons for hospital visits for osteoporosis.Conclusions: Variations in perceptions according to the issue and group were identified. These should be considered during patient consultations to improve compliance with osteoporosis treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis

Lee,

Lee

et al. 2024

J Bone Metab

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“…It was reported one-year compliance was lower than 25% in all osteoporosis therapies, leaving patients with higher risk for fractures and public health costs. [7] Among the antiresorptive osteoporosis drugs, there are numerus studies on compliance of BP, [8][9][10][11][12][13][14] whereas, there are relatively few studies on compliance of SERM. [3,15,16] The primary objective of this study was (1) to evaluate the compliance to SERM medication in postmenopausal women with osteoporosis; and (2) to determine the risk of osteoporotic fractures according to the compliance or other patient characteristics, using the Korean National Health Insurance (KNHI) claims database.…”

Section: Introductionmentioning

confidence: 99%

Osteoporotic Fractures among Selective Estrogen Receptor Modulator Users in South Korea: Analysis Using National Claims Database

et al. 2022

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Background: We evaluated (1) compliance with selective estrogen receptor modulator (SERM) use in postmenopausal women; and (2) the risk of osteoporotic fractures according to compliance and other patient characteristics.Methods: National claims data of postmenopausal women from January 2013 to December 2014 were reviewed. Demographics, comorbidities, type of medical institution, and patient compliance were investigated. Compliance was measured according to medication possession ratio (MPR) and the patients were classified into compliant (MPR ≥80%) or non-compliant (MPR <80%) groups. Osteoporotic fractures were followed up for 2 years after prescription.Results: Among 15,166 postmenopausal women, 4,130 were categorized as compliant. Osteoporotic fractures were confirmed in 669 patients. The hip fracture rate in the non-compliant group (0.39%) was marginally higher than that in the compliant group (0.36%; P=0.06). Compared to age 50 to 54 years, age 55 to 59 years showed protection against fractures (hazard ratio [HR], 0.57; 95% confidence interval [CI], 0.379–0.857; P=0.007), while those over 70 years showed a higher risk of fractures (HR, 2.035; 95% CI, 1.485–2.789; P<0.0001 for age 70–74 years; HR, 2.197; 94% CI, 1.588–3.041; P<0.0001 for age 75–79 years; and HR, 3.53; 95% CI, 2.493–4.999; P<0.0001 for age ≥80 years). Patients with mild (HR, 1.29; 95% CI, 1.088-1.530; P=0.0034) and moderate (HR, 1.286; 95% CI, 1.002–1.652; P=0.0486) comorbidities were associated with higher risks of fractures compared to those without comorbidities.Conclusions: Among postmenopausal women with osteoporosis, only 27.2% complied with SERM therapy. A marginal difference in hip fracture rate was observed between the compliant and non-compliant groups. Older age and severe comorbidities were associated with higher risks of osteoporotic fractures.

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Long-Term Oral Bisphosphonate Compliance Focusing on Switching of Prescription Pattern

Cited by 2 publications

References 39 publications

Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis

Patient Perception on Osteoporosis in Korean Female Patients with Osteoporosis

Osteoporotic Fractures among Selective Estrogen Receptor Modulator Users in South Korea: Analysis Using National Claims Database

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