Long-term Outcome After Survival of a Cardiac Arrest: A Prospective Longitudinal Cohort Study

Moulaert, Véronique; Heugten, Caroline van; Gorgels, Ton; Wade, Derick T; Verbunt, Jeanine

doi:10.1177/1545968317697032

Cited by 80 publications

(127 citation statements)

References 45 publications

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“…As regards self-assessed health, the improvements seen in this study confirm the results of two previous longitudinal studies 9 10. However, these previous studies found that the greatest health-related improvements occurred in the early stages of recovery, within 3 months after cardiac arrest 9 10. Moreover, although the ‘minimal clinically important difference’ in the HADS and EQ-5D-3L among survivors of cardiac arrest is unknown, estimates from other patient populations indicate that the improvements seen in this study might not be clinically noticeable 28 29…”

Section: Discussionsupporting

confidence: 89%

“…It is possible that the heterogeneity in psychological outcomes observed in this study could explain a part of the discrepancies in the available literature. As regards self-assessed health, the improvements seen in this study confirm the results of two previous longitudinal studies 9 10. However, these previous studies found that the greatest health-related improvements occurred in the early stages of recovery, within 3 months after cardiac arrest 9 10.…”

Section: Discussionsupporting

confidence: 89%

“…In this study, the outcome was dichotomised as good or bad in comparison to mean scores from the average Swedish population. Prior studies have concluded that many survivors reach an psychological state and health comparable to the average population, although no study has previously investigated predictors of this outcome 9 10 30. In addition, there is also a lack of knowledge regarding factors associated with postcardiac arrest improvement over time 13 31.…”

Section: Discussionmentioning

confidence: 99%

“…Time to awakening, gender, age, role of bystander, use of hypothermia and percutaneous coronary intervention have previously been related to the outcome after cardiac arrest 6 12 13. However, few studies have investigated the psychological and health-related outcome in the same sample over time,9 10 14 and little is known about factors associated with postcardiac arrest improvement in these aspects. The interpretation of the available literature is complicated by high heterogenicity in study outcomes, and knowledge regarding psychological distress and self-assessed health after OHCA in relation to the average population is lacking 7 15…”

Section: Introductionmentioning

confidence: 99%

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One-year longitudinal study of psychological distress and self-assessed health in survivors of out-of-hospital cardiac arrest

et al. 2019

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ObjectivesFew studies have investigated the psychological and health-related outcome after out-of-hospital cardiac arrest (OHCA) over time. This longitudinal study aims to evaluate psychological distress in terms of anxiety and depression, self-assessed health and predictors of these outcomes in survivors of OHCA, 3 and 12 months after resuscitation.MethodsRecruitment took place from 2008 to 2011 and survivors of OHCA were identified through the national Swedish Cardiopulmonary Resuscitation Registry. Inclusion criteria were age ≥18 years, survival ≥12 months and a Cerebral Performance Category score ≤2. Questionnaires containing the Hospital Anxiety and Depression Scale and European Quality of Life 5 Dimensions 3 Level (EQ-5D-3L) were administered at 3 and 12 months after the OHCA. Participants were also asked to report treatment-requiring comorbidities.ResultsOf 298 survivors, 85 (29%) were eligible for this study and 74 (25%) responded. Clinically relevant anxiety was reported by 22 survivors at 3 months and by 17 at 12 months, while clinical depression was reported by 10 at 3 months and 4 at 12 months. The mean EQ-5D-3L index value increased from 0.82 (±0.26) to 0.88 (±0.15) over time. There were significantly less symptoms of psychological distress (p=0.01) and better self-assessed health (p=0.003) at 12 months. Treatment-requiring comorbidity predicted anxiety (OR 4.07, p=0.04), while being female and young age predicted poor health (OR 6.33, p=0.04; OR 0.91, p=0.002) at 3 months. At 12 months, being female was linked to anxiety (OR 9.23, p=0.01) and depression (OR 14.78, p=0.002), while young age predicted poor health (OR 0.93, p=0.003).ConclusionThe level of psychological distress and self-assessed health improves among survivors of OHCA between 3 and 12 months after resuscitation. Higher levels of psychological distress can be expected among female survivors and those with comorbidity, while survivors of young age and who are female are at greater risk of poor health.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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One-year longitudinal study of psychological distress and self-assessed health in survivors of out-of-hospital cardiac arrest

et al. 2019

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“…Cardiogenic global brain hypoxia-ischemia is a devastating event that is associated with great morbidity and prolonged intensive medical treatment. 1 2 According to the 2013 update of Heart Disease and Stroke Statistics by the American Heart Association (AHA), only 9.5% of adult out-of-hospital cardiac arrest (CA) patients and 23.9% of adult in-hospital CA patients survived to hospital discharge. 3 For those patients who survive to hospital discharge, neurologic injury remains a source of significant morbidity.…”

Section: Introductionmentioning

confidence: 99%

Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest

et al. 2018

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Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia induced-cardiac arrest and global brain hypoxia-ischemia. High concentration hydrogen gas was either administered starting 1 hour prior to cardiac arrest for 1 hour and starting 1 hour post-resuscitation for 1 hour (pre- & post-treatment) or starting 1 hour post-resuscitation for 2 hours (post-treatment). In animals subjected to 9 minutes of asphyxia, both therapeutic regimens tended to reduce the incidence of seizures and neurological deficits within 3 days post-resuscitation. In rats subjected to 11 minutes of asphyxia, significantly worse neurological deficits were observed compared to 9 minutes asphyxia, and pre- & post-treatment had a tendency to improve the success rate of resuscitation and to reduce the seizure incidence within 3 days post-resuscitation. Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia.

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Out‐of‐hospital cardiac arrest research

Grunau¹,

Smith²,

Panchal³

2021

Emergency Medical Services

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Long-term Outcome After Survival of a Cardiac Arrest: A Prospective Longitudinal Cohort Study

Abstract: Overall, long-term outcome in terms of activities, participation, and quality of life after cardiac arrest is reassuring. Nevertheless, fatigue is common; problems with cognition and emotions occur; and return to work can be at risk.

Cited by 80 publications

References 45 publications

One-year longitudinal study of psychological distress and self-assessed health in survivors of out-of-hospital cardiac arrest

One-year longitudinal study of psychological distress and self-assessed health in survivors of out-of-hospital cardiac arrest

Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest

Out‐of‐hospital cardiac arrest research

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