Long-term outcome following radical prostatectomy for Gleason 8–10 prostatic adenocarcinoma

Abstract

Although historically underutilized in patients with poorly differentiated disease, radical prostatectomy provides excellent long-term survival and should be offered to healthy patients.

Extended versus limited pelvic lymph node dissection during bilateral nerve-sparing radical prostatectomy and its effect on continence and erectile function recovery: long-term results and trifecta rates of a comparative analysis

“…This difference might be explained in part by the fact that patients with lPLND (low-risk PCa) display more favorable parameters in terms of PSA/Gleason score with decreased likelihood of BCR in comparison with intermediate-and high-risk PCa (ePLND) [16][17][18][19]. In this regard, it should be emphasized that most of the results of our study did not show a significant difference between the ePLND and lPLND groups.…”

Added Value of Multiparametric Ultrasonography in Magnetic Resonance Imaging and Ultrasonography Fusion–guided Biopsy of the Prostate in Patients With Suspicion for Prostate Cancer

“…However, a recent analysis of 30,379 men identified from the Surveillance, Epidemiology, and End Results (SEER) 18 registry data set with high-grade disease undergoing radical prostatectomy showed an excellent long-term survival. 24 Although a recent study 16 found a 32% rate of increased or upgraded Gleason score in comparison to a standard extended 12-core biopsy alone, we did not include an analysis of the postoperative Gleason scores. Because upgrading could also result in upstaging, preoperative predictors about the presence of occult extraprostatic and/or highgrade PCa need to be urgently investigated in future studies.…”

Pelvic lymph node dissection and its extent on survival benefit in prostate cancer patients with a risk of lymph node invasion >5%: a propensity score matching analysis from SEER database

“…reviewed data of 752 patients in the USA and reported that PLND status was not associated with CSS 13 . Interestingly, Pokala and colleagues analyzed long-term outcomes in patients with high-grade PCa and found that patients with PLND had shorter CSS than patients without PLND 14 . However, no obvious difference in OS was observed between two groups.…”