Long-term Outcome of Chronic Hepatitis B in Adolescents or Young Adults in Follow-up From Childhood

Fujisawa, Tomoo; Komatsu, Haruki; Inui, Ayano; Sogo, Tsuyoshi; Miyagawa, Yoshihiro; Fujitsuka, Satoshi; Sekine, Isao; Kosugi, Takeshi; Inui, Michio

doi:10.1097/00005176-200002000-00019

Cited by 36 publications

(39 citation statements)

References 22 publications

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“…14 Fujisawa et al followed up 52 children around 11 years of age and they reported seroconversion rate of 50% that was slightly lower than our findings. 15 These findings show that the longer the duration of follow-up, the higher seroconversion to anti-HBe.In this study, we found that seroconversion rate in children born to antiHBeAg-positive mothers (66.1% of 115 cases) was higher than the HBeAg-positive mothers (p < 0.0001). Tseng et al reported that 48.8% children born to 80 HBeAg-positive mothers and 73.7% of 57 children born to anti-HBe-positive mothers seroconverted to anti-HBe.…”

Section: Discussionmentioning

confidence: 85%

HBeAg seroconversion in children infected during early childhood with hepatitis B virus

Roushan

Bijani

Ramzaninejad

et al. 2012

Journal of Clinical Virology

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Objective In this study we aimed to assess the attitudes and practices of medical students regarding hepatitis A immunization and also adverse reactions of associated with vaccine and effect on acceptability. Methods The study was performed on 103 medical students with ages between 20 and 26 years old. All the students vaccinated by the same nurse at Hacettepe University Faculty of Medicine on 14 days in December and answered a questionnaire and follow-up form. Results The mean student age was 21.69±0.97 years. Pain with movement (58.3%) and pain with touch (38.8%) were the most common side effects at vaccination site. Despite the side effects, all of the vaccinated students wanted to receive the following dose of vaccine. Twelve of the vaccinated students (11.7 %) indicated that the reason of their vaccination was the recommendation of a pediatric infectious disease specialist. One of the major reason for not wishing vaccination was the cost for 60 of them (58.3%).

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Section: Discussionmentioning

confidence: 85%

HBeAg seroconversion in children infected during early childhood with hepatitis B virus

Roushan

Bijani

Ramzaninejad

et al. 2012

Journal of Clinical Virology

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“…Three studies [13,19,21] were performed in Europe, three [14,17,20] in Japan, and one each in Thailand [12] and Taiwan [8]. The sample size of each study varied greatly, ranging from 52 [20] to 404 patients [13]. Variable IFN schedules were used, both for total dose and for length of treatment.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

2009

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“…During the observation period, 67 children remained untreated, and 41 were treated with IFN-a; these patients had been included in clinical trials performed at our department in previous years [21]. At baseline, treated and untreated patients were comparable with regard to demographic, clinical, and laboratory features (table 1).…”

Section: Resultsmentioning

confidence: 99%

“…In a study including 52 children followed up for 3-22 years, Fujisawa et al [21] reported a percentage of HBeAg clearance of 83.3% in untreated patients and 87.5% in treated patients; none of the patients achieved an undetectable HBsAg level. The authors explained that this lower rate of HBsAg clearance was a result of perinatal acquisition of HBV infection.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Outcome in Children with Chronic Hepatitis B: A 24-Year Observation Period

Iorio

Giannattasio

Cirillo

et al. 2007

Clinical Infectious Diseases

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Background. Chronic hepatitis B seems to manifest as mild disease in children and young adults. However, data regarding the long-term course of hepatitis B in untreated and interferon-treated children are still scarce. This study investigates the long-term outcome of disease in a large series of untreated and treated children with hepatitis B virus (HBV) infection.Methods. Clinical, biochemical, virological, and histological features were evaluated in children (age range, 2-18 years) with chronic HBV infection who did not have concomitant chronic systemic diseases other than HBV infection and who were admitted to the liver unit in the Department of Pediatrics at University "Frederico II" (Naples, Italy) during the period 1981-2005.Results. One hundred eight consecutive patients observed for up to 24 years were studied. During the observation period, 67 children remained untreated, and 41 were treated with interferon-a. After a median period of observation of 12.1 years (range, 5-23 years), hepatitis B early antigen loss and serum HBV DNA clearance occurred in 43 untreated patients (69.3%) who were hepatitis B early antigen positive at study entry and in 33 treated children (80%; the P value is not statistically significant). In addition, 6 untreated patients (9.7%) and 4 treated patients (9.7%) became hepatitis B surface antigen positive at the end of the follow-up period. Histological assessment, evaluated for 57 children, showed mild-to-moderate disease in 91.2% of cases of HBV infection. No patient developed end-stage liver disease or hepatocellular carcinoma.Conclusions. Children with chronic HBV infection are symptom free, with morphologically mild liver disease. Considering that the overall long-term outcomes did not differ between treated and untreated patients, the real impact of therapy on the long-term course of HBV infection remains to be established. Additional studies are needed to confirm our conclusions.

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Long-term Outcome of Chronic Hepatitis B in Adolescents or Young Adults in Follow-up From Childhood

Abstract: All children carrying hepatitis B surface antigen should be observed carefully to monitor the possible development of hepatocellular carcinoma, especially in the antihepatitis B e-positive phase after spontaneous seroconversion or even after interferon treatment.

Cited by 36 publications

References 22 publications

HBeAg seroconversion in children infected during early childhood with hepatitis B virus

HBeAg seroconversion in children infected during early childhood with hepatitis B virus

Meta-analysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Long-Term Outcome in Children with Chronic Hepatitis B: A 24-Year Observation Period

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