Long-Term Outcome of Controlled, Non—Heart-Beating Donor Liver Transplantation

Manzarbeitia, Cosme; Ortíz, Jorge; Jeon, Hoonbae; Rothstein, Kenneth D.; Martínez, Óscar Núñez; Araya, Víctor; Muñoz, Santiago J.; Reich, David J.

doi:10.1097/01.tp.0000128327.95311.e3

Cited by 105 publications

(60 citation statements)

References 15 publications

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“…The follow-up is, however, still relatively short and more data are needed on the longerterm outcomes. The encouraging long-term results from Manzarbeitia et al with adult recipients show that the cautious use of NHBD livers produces survivals, which are no different than for those recipients receiving standard heartbeating deceased donor grafts, with a similar incidence of vascular and biliary complications (10).…”

Section: Discussionmentioning

confidence: 84%

Segmental Liver Transplantation from Non-Heart Beating Donors—An Early Experience with Implications for the Future

Muiesan

Jassem

Girlanda

et al. 2006

American Journal of Transplantation

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We report our experience of pediatric liver transplantation with partial grafts from non-heart beating donors (NHBD). Controlled donors less than 40 years of age with a warm ischemia time (WI) of less than 30 min were considered for pediatric recipients. Death was declared 5 min after asystole. A super-rapid recovery technique with aortic and portal perfusion was utilized. Mean donor age was 29 years and WI 14.6 min (range 11-18). Seven children, mean age 4.9 years (0.7-11), median weight 20 kg (8.4-53) received NHBD segmental liver grafts. Diagnoses included seronegative hepatitis, neonatal sclerosing cholangitis, familial intrahepatic cholestasis, hepatoblastoma, primary hyperoxaluria and factor VII deficiency (n = 2).The grafts included four reduced and one split left lateral segments, one left lobe and one right auxiliary graft. Mean cold ischemia was 7.3 h (6.2-8.8). Complications included one pleural effusion and one biliary collection drained percutaneously. At 20 months (10-36) followup all children are alive and well with functioning grafts. Donation after cardiac death is a significant source of liver grafts for adults and children with careful donor selection and short cold ischemic times.

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Section: Discussionmentioning

confidence: 84%

Segmental Liver Transplantation from Non-Heart Beating Donors—An Early Experience with Implications for the Future

Muiesan

Jassem

Girlanda

et al. 2006

American Journal of Transplantation

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“…Concerns regarding prolonged ischemia time and graft dysfunction have been raised; however, several reports have indicated that renal and liver grafts from DCD donors have graft function and transplant recipient survival rates comparable to those with organs recovered from braindead donors. [15][16][17][18][19] In addition, lungs from DCD donors are now being recovered with good success. 9 The Institute of Medicine and the American College of Critical Care Medicine both endorse DCD as a means to recover organs for transplantation.…”

Section: Organ Donationmentioning

confidence: 99%

Pediatric Organ Donation and Transplantation

Surgery¹

2010

Pediatrics

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Pediatric organ donation and organ transplantation can have a significant life-extending benefit to the young recipients of these organs and a high emotional impact on donor and recipient families. Pediatricians, pediatric medical specialists, and pediatric transplant surgeons need to be better acquainted with evolving national strategies that involve organ procurement and organ transplantation to help acquaint families with the benefits and risks of organ donation and transplantation. Efforts of pediatric professionals are needed to shape public policies to provide a system in which procurement, distribution, and cost are fair and equitable to children and adults. Major issues of concern are availability of and access to donor organs; oversight and control of the process; pediatric medical and surgical consultation and continued care throughout the organ-donation and transplantation process; ethical, social, financial, and follow-up issues; insurance-coverage issues; and public awareness of the need for organ donors of all ages.

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“…Increasing DRI has been strongly correlated with decreasing graft and patient survival. While these 'marginal' organs can be successfully used in the proper patient, they are at higher risk of graft dysfunction, graft failure and potentially decreased patient survival (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

The Economic Impact of the Utilization of Liver Allografts with High Donor Risk Index

Axelrod

Salvalaggio

Swindle

et al. 2007

American Journal of Transplantation

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Long-Term Outcome of Controlled, Non—Heart-Beating Donor Liver Transplantation

Abstract: CNHBD safely expands the donor pool with similar long-term results as those obtained in patients receiving organs from brain-dead donors under standard procurement techniques.

Cited by 105 publications

References 15 publications

Segmental Liver Transplantation from Non-Heart Beating Donors—An Early Experience with Implications for the Future

Segmental Liver Transplantation from Non-Heart Beating Donors—An Early Experience with Implications for the Future

Pediatric Organ Donation and Transplantation

The Economic Impact of the Utilization of Liver Allografts with High Donor Risk Index

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