Long‐Term Outcome of Home Parenteral Nutrition in Patients With Ultra‐Short Bowel Syndrome

Abstract

The survival of patients with U-SBS receiving HPN was good. Although IFALD was frequent, it had been manageable in most of the patients, but in a single complex case, it led to death. The multidisciplinary management warranted to these patients to approach the school age, to grow, and to maintain the oral intake. Patients with U-SBS are rare, and to better understand their long-term survival, further studies, including more large patient populations, are required.

Management of intestinal failure in children

“…The outcome for children is excellent as reported by the larger centres in Europe and North America,12 with 90% of children achieving independence from artificial nutrition support within 2 years and a mortality rate of <10%. Most deaths occur within the first 6 months and are due to sepsis, IFALD,11 13 and associated system abnormalities.…”

Clinical case and short review of extreme short bowel syndrome: an update 21 years after

“…who survived in good clinical condition, but in all these cases the ileocecal valve had been spared, and PN support could not be eliminated in most cases. 6,[14][15][16][17] The main factor that could explain such a successful recovery may have been, in our hypothesis, the protracted breast-feeding. Human milk plays a very positive influence on cell proliferation and on adaptive transformation of the residual intestine.…”

Ethical aspects of care in the newborn surgical patient

“…Intestinal transplantation is emerging as a potential option for these children. 34 On the other hand, Diamanti et al 35 found good quality of life in a small group of children with ultra-short bowel syndrome. Although still dependent on parenteral nutrition, the children regularly attended school and none was listed for intestinal transplantation.…”

“…Although still dependent on parenteral nutrition, the children regularly attended school and none was listed for intestinal transplantation. 35 Today, intestinal transplantation for newborns with ultra-short bowel syndrome is certainly not standard practice. Cummings et al 36 asked neonatologists and pediatric surgeons whether they viewed intestinal transplant in neonates with severe short bowel syndrome as impermissible, optional, or obligatory.…”