Long-term outcome of laparoscopic sleeve gastrectomy from a single center in mainland China

Hans, Pankaj Kumar; Guan, Wei; Lin, Shibo; Liang, Hui

doi:10.1016/j.asjsur.2017.04.003

Cited by 29 publications

(23 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To best of our knowledge, the present study is the largest cohort study that evaluated the effectiveness of bariatric surgery among Chinese population using population-based data. [15][16][17][38][39][40] The results of this study were in line with the conclusion of previous observational studies and randomised controlled trials (RCTs), which found that bariatric surgery provided substantial and sustainable effects on weight loss, glycaemic control, and lipid profile improvement. 15,42,[44][45][46] However, observations of the present study were at variance with other studies regarding to diabetes remission and weight loss in quantitative aspect and hypertension remission from qualitative perspective.…”

Section: Discussionsupporting

confidence: 90%

“…To best of our knowledge, the present study is the largest cohort study that evaluated the effectiveness of bariatric surgery among Chinese population using population‐based data . Also, this study made a comprehensive illustration of metabolic and weight outcomes, including complete and partial remission rates of diabetes, remission rates of hypertension, high LDL‐C, low HDL‐C, high triglycerides and dyslipidaemia, and improvement of BMI, HbA 1c , SBP, DBP, LDL‐C, %TWL, %EWL, and %REWL.…”

Section: Discussionmentioning

confidence: 95%

“…[5][6][7] Around 75% to 90% of patients who underwent bariatric surgery achieved comorbidity resolution, particularly for patients with insulin resistance, hypertension, and respiratory disorders. 4 Though relapse in recovered patients may occur over time, the long-term effect of bariatric surgery on disease remission was supported by a systematic review, where 66.7% of T2DM patients, 38.2% of hypertensive patients, and 60.4% dyslipidaemia patients achieved disease remission at up to 5 years after bariatric surgery. 8 A prospective cohort study with a follow-up across 15 years found that diabetes remission rates dropped gradually but still exceeded 30% at 15 years after the surgery.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Five‐year effectiveness of bariatric surgery on disease remission, weight loss, and changes of metabolic parameters in obese patients with type 2 diabetes: A population‐based propensity score‐matched cohort study

Wong

Law

et al. 2020

Diabetes Metabolism Res

View full text Add to dashboard Cite

Aims To compare disease remission rates, weight loss, and changes of metabolic parameters of patients after bariatric surgery with nonsurgical patients. Methods Based on the 2006‐2017 Hospital Authority database, a population‐based retrospective cohort of obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery were identified. Surgical patients were matched with nonsurgical patients on 1‐to‐5 propensity score. Remission rates of diabetes, hypertension, and dyslipidaemia were reported annually up to 60 months. Changes in weight loss measurements (Body Mass Index [BMI], percentage of total weight loss [%TWL], percentage of excess weight loss [%EWL], and percentage of rebound in excess weight loss [%REWL]) and metabolic parameters (haemoglobin A1c [HbA1c], systolic blood pressure [SBP], diastolic blood pressure [DBP], and low‐density lipoprotein cholesterol [LDL‐C]) were measured for both groups. Results Four hundred one surgical patients (310 restrictive surgeries; 91 bypass surgeries) and 1894 nonsurgical patients were included. Surgical patients had higher remission rates in diabetes and dyslipidaemia and better glycaemic control at 12 to 60 months (all Ps < .01). SBP and DBP were significantly lower for surgical group up to 12 months and similar between two groups after 12 months. Surgical patients had significantly lower BMI during follow‐up period. %TWL and %EWL were higher in the surgery group (15.7% vs 3.7%; 48.8% vs 12.0%) at 60 months (P < .001); differences in %REWL between two groups were insignificant. The effectiveness of restrictive and bypass surgeries was similar at 60 months, although restrictive surgeries were slightly more effective in T2DM remission. Conclusions Bariatric surgery was effective in weight loss, remission of diabetes, and dyslipidaemia in 5‐year post‐surgery.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Five‐year effectiveness of bariatric surgery on disease remission, weight loss, and changes of metabolic parameters in obese patients with type 2 diabetes: A population‐based propensity score‐matched cohort study

Wong

Law

et al. 2020

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…Waist circumference: male >90 cm, female >85 cm. The weight of subjects was stable for at least 3 months prior to surgery [13].…”

Section: Study Design and Subjectsmentioning

confidence: 99%

“…Subjects were excluded if they had cardiovascular dis-ease, arthritis, acute inflammatory disease, infectious disease, gastrointestinal surgery previously or were receiving drugs that could alter the lipid profile or the metabolic parameters at inclusion in the study [13].…”

Section: Study Design and Subjectsmentioning

confidence: 99%

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity

Guan

et al. 2019

Endocr J

Self Cite

View full text Add to dashboard Cite

Obesity is linked to a low-grade systemic inflammation and lipopolysaccharide (LPS) is a key factor. Sleeve gastrectomy (SG) can significantly cause weight loss, but few reports have looked into the changes of LPS and inflammatory cytokines after surgery. To explore the potential short-term impact of SG on LPS and inflammatory cytokines and their relationship to early metabolic changes in obesity. 30 Chinese adults with obesity (BMI 39.37 ± 8.22 kg/m 2 , 25 female) receiving SG were included in this study. Fasting blood samples were collected at baseline and 30 days after SG. Serum LPS markedly reduced from 336.50 (73.54, 500) pg/mL to 5.00 (5.00, 5.24) pg/mL at 1 month after SG (p < 0.05). There was a significant decrease in plasma IL-6, IL-8, and serum CRP after SG (all p < 0.05). Insulin resistance improved remarkably after surgery as displayed by reductions in fasting insulin level (FINS, p < 0.001), and HOMA-IR (p < 0.001). In addition, visceral fat area (VFA) decreased from 209.70 ± 39.96 cm 2 to 193.28 ± 43.68 cm 2 after SG (p < 0.001). LPS was positively correlated with FINS (r = 0.391, p = 0.033) and HOMA-IR (r = 0.38, p = 0.038) before SG. Meanwhile, VFA was positively associated with CRP (r = 0.388, p = 0.034) before surgery. When assessing 30-days postoperative changes, a positive correlation was found between the variations of LPS, IL-8 and the reduction of VFA. After multivariate analyses, only the reduced IL-8 level was independently associated with the reduction of VFA (p = 0.015). In conclusion, SG can significantly relieve the inflammation in obesity in the short term and LPS might be an earlier predictor of inflammatory changes after surgery.

show abstract

Functional Characterization of MC4R Variants in Chinese Morbid Obese Patients and Weight Loss after Bariatric Surgery

Gong

Huang

et al. 2023

Advanced Biology

Self Cite

View full text Add to dashboard Cite

Mutations in MC4R are the most common genetic cause of obesity. In the reported Chinese morbid obesity cohort, 10 out of 59 harbor six MC4R variants, including Y35C, T53I, V103I, R165W, G233S, and C277X, among which V103I has a relatively high frequency, while other five variants are rare in the population. The prevalence of MC4R carriers in Chinese morbid obese patients (body mass index ≥ 45 kg m−2) is detected as 16.9% in this study. R165W and C277X are loss‐of‐function variants. The patient with R165W achieves excess weight loss (%EWL) as high as 20.6% and 50.3% at 1 and 8 months after surgery, respectively. G233S is reported for the first time in Asia obese population. The patient harboring G233S has a %EWL as 23.3% one month postsurgery. It is concluded that morbid obese patients with rare MC4R variants can benefit from metabolic surgery. More importantly, the choice of surgery procedure and MC4R variant should be taken into consideration for personalized treatment. In the future, a larger size cohort, accompanied with regular and longer follow‐up, would be helpful.

show abstract

Long-term outcome of laparoscopic sleeve gastrectomy from a single center in mainland China

Abstract: LSG is a safe and effective procedure with good five year results. Weight regain remains a concern two years post surgery. Standardization of LSG is important to reduce major complications.

Cited by 29 publications

References 30 publications

Five‐year effectiveness of bariatric surgery on disease remission, weight loss, and changes of metabolic parameters in obese patients with type 2 diabetes: A population‐based propensity score‐matched cohort study

Five‐year effectiveness of bariatric surgery on disease remission, weight loss, and changes of metabolic parameters in obese patients with type 2 diabetes: A population‐based propensity score‐matched cohort study

Lipopolysaccharide and inflammatory cytokines levels decreased after sleeve gastrectomy in Chinese adults with obesity

Functional Characterization of MC4R Variants in Chinese Morbid Obese Patients and Weight Loss after Bariatric Surgery

Contact Info

Product

Resources

About