Long‐term outcome of patients with bipolar disorder commenced on lithium prophylaxis during hospitalization: a complete 15‐year register‐based follow‐up

Licht, Rasmus W; Vestergaard, Per; Brodersen, A.

doi:10.1111/j.1399-5618.2008.00499.x

Cited by 36 publications

(21 citation statements)

References 19 publications

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“…People who attempt suicide once are more likely to die from all other causes of death in the next 5 years in comparison with the rest of the population 16, 17. Different studies have reported somewhat different findings, with death rates ranging from 4% to 15% 5 to 15 years after a suicide attempt 16, 18, 19. This is actually similar to the overall 5‐year patient survival rate after LT.…”

Section: Discussionsupporting

confidence: 52%

Overdose with suicidal intent: Ethical considerations for liver transplant programs

Aggarwal

Schiano

2011

Liver Transpl

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Liver transplantation (LT) programs encounter patients with fulminant hepatic failure resulting from suicide attempts involving acetaminophen or multidrug ingestion. Members of transplant teams often have different opinions about whether these patients should be offered transplantation. Disagreements can delay the transfer of these patients to a transplant facility and negatively affect their management. Currently, transplant programs have no guidelines to help them with their decisions about the appropriateness of LT for these patients. Here we present a clinical case encountered at our facility, and we discuss ethical principles that should help programs to make informed decisions about transplantation for these patients. Liver

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Section: Discussionsupporting

confidence: 52%

Overdose with suicidal intent: Ethical considerations for liver transplant programs

Aggarwal

Schiano

2011

Liver Transpl

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“…-the question raised in an editorial [41] , can now be answered conclusively: yes, it does, if the treatment is applied and monitored in a rational, careful and individualized way. While there are rare negative findings in this respect [42] , they can most likely be explained by incomplete patient follow-up and insufficient information on patients' compliance with lithium. This saving of lives considerably adds to the preference of lithium when the cost-effectiveness of treatment with various mood stabilizers is assessed [43] .…”

Section: Resultsmentioning

confidence: 94%

Lithium Reduces Pathological Aggression and Suicidality: A Mini-Review

2010

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From a practical point of view, the well-proven antisuicidal and anti-aggressive effects of lithium are of utmost importance for a rational, safe and economical treatment of patients with affective disorders. Regular lithium long-term treatment reduces the otherwise 2- to 3-fold increased mortality of untreated patients with severe affective disorders down to the level of the general population. This is mainly due to the reduced suicide risk. Many international studies have confirmed this fascinating property of lithium which so far has not been demonstrated with comparable evidence for any other psychotropic compound. The antisuicidal effects of lithium might possibly be related to its anti-aggressive effects which have been shown in various species, populations and settings, such as animals, inhabitants of nursing homes for the elderly, mentally handicapped subjects, children and adolescents with hyperactive, hostile and aggressive behavior, and particularly in hyperaggressive inmates of correction units and prisons.

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“…Despite the widespread clinical belief that antidepressants may trigger bipolar symptoms in susceptible individuals, empirical evidence for this is lacking (19). However, addition of a mood stabilizer after response to antidepressant treatment may be beneficial in those who manifest sub-threshold bipolarity (38). …”

Section: Discussionmentioning

confidence: 99%

Major Depressive Disorder With Subthreshold Bipolarity in the National Comorbidity Survey Replication

Angst

Cui²,

Swendsen³

et al. 2010

AJP

275

248

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Objectives There is growing clinical and epidemiologic evidence indicating that major mood disorders form a spectrum from Major Depressive Disorder (MDD) to pure mania. The present investigation examined the prevalence and clinical correlates of MDD with sub-threshold bipolarity vs. pure MDD in the National Comorbidity Survey Replication (NCS-R). Methods The NCS-R is a nationally representative face-to-face household survey of the U.S. population conducted between February, 2001 and April, 2003. Lifetime history of mood disorders, symptoms and clinical indicators of severity were collected using version 3.0 of the WHO Composite International Diagnostic Interview, a fully structured lay-administered diagnostic interview. Results Nearly 40% of study participants with a history of major depressive disorder had a history of sub-threshold hypomania. This subgroup had a younger age of disorder onset, more episodes of depression, and higher rates of comorbidity than those without a history of hypomania, and lower levels of clinical severity than those with bipolar II disorder. Conclusions The findings demonstrate heterogeneity of major depressive disorder and support the validity of inclusion of sub-threshold mania in the diagnostic classification. The broadening of criteria for bipolar disorder would have important implications for research and clinical practice.

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Long‐term outcome of patients with bipolar disorder commenced on lithium prophylaxis during hospitalization: a complete 15‐year register‐based follow‐up

Abstract: The overall outcome in patients beginning prophylactic treatment is unsatisfactory. However, due to the observational design and the lack of detailed treatment information during the long follow-up period, inferences about the efficacy of lithium cannot be made from this study.

Cited by 36 publications

References 19 publications

Overdose with suicidal intent: Ethical considerations for liver transplant programs

Overdose with suicidal intent: Ethical considerations for liver transplant programs

Lithium Reduces Pathological Aggression and Suicidality: A Mini-Review

Major Depressive Disorder With Subthreshold Bipolarity in the National Comorbidity Survey Replication

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