Long‐term outcome with focus on pulmonary hypertension in Obesity Hypoventilation Syndrome

Budweiser, Stephan; Tratz, Florian; Gfüllner, Florian; Pfeifer, Michael

doi:10.1111/crj.13225

Cited by 3 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Healthcare utilisation is high [ 10 ], with more frequent hospitalisations than for patients with OSA [ 11 ]. OHS also places a significant burden on health-related quality of life, which is worse than in patients with OSA [ 12 ] and worsens despite treatment with ventilator therapy [ 13 ].…”

Section: The Problem With Ohsmentioning

confidence: 99%

Defining obesity hypoventilation syndrome

Shah

Shrimanker

Kaltsakas

2021

Breathe

View full text Add to dashboard Cite

With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pickwickian syndrome” in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension >45 mmHg) in patients with body mass index >30 kg·m−2 in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion.Educational aimsTo provide an overview of the historical basis of the definition of obesity hypoventilation syndrome.To explain the rationale for the current definition of obesity hypoventilation syndrome.To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome.

show abstract