Long-term outcomes after surgical resection for gastric cancer liver metastasis: an analysis of 64 macroscopically complete resections

Abstract

GLM patients with the maximum diameter of hepatic tumors of <5 cm and without serosal invasion of the primary gastric cancer are the best candidate for hepatectomy.

Surgical resection of hepatic metastasis from gastric cancer: a review and new recommendation in the Japanese gastric cancer treatment guidelines

“…The 5-year survival reported from each series ranged from 0 % to 37 % and exceeded 30 % in five series [6,10,12,15,16]. Median survival time ranged from 9 to 38.8 months.…”

“…Because most institutions needed more than a decade to accumulate 15 patients or more, there should have been much difference in the potential of imaging modalities at the beginning and the end of the study period. In the largest single-institution series, Takemura et al [6] reported a 5-year survival of 37 %. It may be of note that they currently consider surgery when the number of metastatic nodules was diagnosed as three or fewer, using state-ofthe-art imaging tools.…”

“…Takemura et al [6] took an aggressive approach in which 18 of 73 patients received neoadjuvant chemotherapy and 31 received postoperative chemotherapy, including 5 cases that received arterial infusion (HAIC) postoperatively. In contrast, Sakamoto et al [14] reported that they delivered chemotherapy only for those who subsequently had recurrences.…”

“…Sixty-eight articles were identified, of which the following were excluded: 15 articles that included either other types of distant metastases or hepatic metastasis from other cancer types with no independent outcome data for gastric cancer metastases, 15 articles with emphasis on treatment modalities other than hepatectomy, 6 articles with fewer than 15 cases, 5 articles on prediction and diagnosis of hepatic metastasis, 4 review articles, 3 articles on irrelevant subjects, and 1 article describing only hepatic metastasis from pT1 stage cancer. Three articles analyzed patients from the same institution, and the most recent report by Takemura et al [6] was selected and added to a total of 17 articles to be analyzed in the current review [2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Most of the papers were retrospective singleinstitution analyses of consecutive patients who underwent hepatectomy during a given period, with two exceptions in which patients were recruited from multiple institutions [5,7].…”

Surgical treatment of liver metastasis of gastric cancer: a retrospective multicenter cohort study (KSCC1302)

“…By contrast, colorectal liver metastases are widely considered as targets of surgery with an intent to cure because they often present as liver-only diseases, and R0 resection showed favorable survival in a recent clinical study [8]. Recently, the Guidelines Committee of the Japan Gastric Cancer Association reconsidered the treatment of potentially resectable M1 disease [9], on the basis of a report that showed favorable results in resectable liver metastases [10][11][12][13][14][15][16][17][18][19][20]. Therefore, the importance of liver resection for liver metastasis must be thoroughly analyzed.…”