Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time

Kashikar‐Zuck, Susmita; Cunningham, N.; Peugh, James; Black, William R.; Nelson, Sarah Milledge; Lynch-Jordan, A.; Pfeiffer, Megan; Tran, Susan T.; Ting, Tracy V.; Arnold, Lesley M.; Carle, Adam C.; Noll, Jennie G.; Powers, Scott W.; Lovell, Daniel J.

doi:10.1097/j.pain.0000000000001415

Cited by 57 publications

(56 citation statements)

References 51 publications

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“…The primary symptom of JPFS is widespread musculoskeletal pain that persists in the absence of an underlying inflammatory disease or other medical condition. In at least a subset of youth with JPFS, pain is associated with significant and enduring impairment in the ability to participate in usual activities and maintain positive well-being [4][5][6][7]. Reducing this functional impairment often is regarded as a primary goal of treatment for JPFS.…”

Section: Introductionmentioning

confidence: 99%

Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

Connelly

Weiss

2019

Pediatr Rheumatol

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Background: Severe pain and impairments in functioning are commonly reported for youth with juvenile fibromyalgia. The prevalence and impact of pain in other diseases commonly managed in pediatric rheumatology comparatively have been rarely systematically studied. The objective of the current study was to determine the extent to which high levels of pain and functional limitations, and the strength of their association, are unique to youth with juvenile primary fibromyalgia syndrome/JPFS) relative to other pediatric rheumatic diseases. Methods: Using data from 7753 patients enrolled in the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, we compared the levels and association of pain and functional limitations between youth with JPFS and those with other rheumatic diseases. Results: Pain levels were rated highest among youth with JPFS (M = 6.4/10, SD = 2.4) and lowest for juvenile dermatomyositis (M = 1.7/10, SD = 2.2), with pain significantly higher in the JPFS group than any other pediatric rheumatic disease (effect sizes = .22 to 1.05). Ratings on measures of functioning and well-being also were significantly worse for patients with JPFS than patients with any other rheumatic disease (effect sizes = .62 to 1.06). The magnitude of association between pain intensity and functional disability, however, generally was higher in other rheumatic diseases than in JPFS. Pain was most strongly associated with functional limitations in juvenile dermatomyositis, juvenile idiopathic arthritis, and mixed connective tissue disease. Conclusions: JPFS is unique among conditions seen in pediatric rheumatology with regard to ratings of pain and disability. However, pain appears to be comparably or more highly associated with level of functional impairment in other pediatric rheumatic diseases. Pain in childhood rheumatic disease thus would benefit from increased prioritization for research and treatment.

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Section: Introductionmentioning

confidence: 99%

Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

Connelly

Weiss

2019

Pediatr Rheumatol

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“… 46 These findings on educational impacts attributed to endometriosis-associated pain are consistent with other chronic pain conditions (such as adolescent fibromyalgia) in young women, which are also associated with increased risk of reduced educational attainment. 49 , 50 …”

Section: Educational Attainmentmentioning

confidence: 99%

Impact of Endometriosis on Life-Course Potential: A Narrative Review

Missmer¹,

Tu²,

Agarwal³

et al. 2021

IJGM

127

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Endometriosis may exert a profound negative influence on the lives of individuals with the disorder, adversely affecting quality of life, participation in daily and social activities, physical and sexual functioning, relationships, educational and work productivity, mental health, and well-being. Over the course of a lifetime, these daily challenges may translate into limitations in achieving life goals such as pursuing or completing educational opportunities; making career choices or advancing in a chosen career; forming stable, fulfilling relationships; or starting a family, all of which ultimately alter one's life trajectory. The potential for endometriosis to impact the life course is considerable, as symptom onset generally occurs at a time of life (menarche through menopause, adolescence through middle age) when multiple life-changing and trajectory-defining decisions are made. Using a lifecourse approach, we examine how the known effects of endometriosis on life-domain satisfaction may impact health and well-being across the life course of affected individuals. We provide a quasi-systematic, narrative review of the literature as well as expert opinion on recommendations for clinical management and future research directions.

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“…The characteristic symptom of JPFS is widespread musculoskeletal pain, usually with a very high subjective severity score [ 3 , 74 – 76 ] . In adolescents with JPFS, pain has a negative effect on well-being and is associated with functional impairment, commonly leading to avoidance of regular daily activities [ 77 , 78 ], school absenteeism [ 79 ], and poor social functioning [ 1 , 80 ]. Pain severity, as well as measures of function and well-being, are significantly worse in youth with JPFS, as compared to those with other pediatric rheumatic diseases, as was shown in a study of 7753 patients enrolled in a multinational registry [ 81 ].…”

Section: Clinical Manifestations Of Jpfsmentioning

confidence: 99%

Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis

2021

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Juvenile primary fibromyalgia syndrome (JPFS) is a chronic, musculoskeletal pain syndrome affecting children and adolescents, most commonly adolescent girls. The syndrome has a multifactorial etiology, with altered central pain processing playing an important role. The hallmark symptom is severe, widespread musculoskeletal pain. Other symptoms include sleep and mood disturbances, headaches, stiffness, and subjective joint swelling. Physical examination can reveal multiple tender points. The diagnosis is clinical, with defined criteria. Early diagnosis and intervention are important. In this part of the review, we discuss the epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis of JPFS. Part two will focus on treatment and prognosis.

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Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time

Cited by 57 publications

References 51 publications

Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases

Impact of Endometriosis on Life-Course Potential: A Narrative Review

Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis

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