Long-term outcomes of children and adolescents who had cerebral palsy with secondary osteoporosis

Iwasaki, Takuya; Nonoda, Yutaka; Ito, Masahiro

doi:10.1185/03007995.2011.645562

Cited by 22 publications

(11 citation statements)

References 30 publications

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“…Because the small sample size makes hard to obtain a statistically meaningful result, further research is necessary to recruit more subjects. Previous studies reported that use of anticonvulsants could increase secondary osteoporosis in children and adolescents with CP 15,16. But in this study, only 3 patients (8.5%) had medical history of taking anticonvulsants, so it was difficult to obtain a statistically significant result.…”

Section: Discussionmentioning

confidence: 64%

Factors Affecting Bone Mineral Density in Adults with Cerebral Palsy

Yoon

Kim

et al. 2012

Ann Rehabil Med

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ObjectiveTo clarify factors affecting bone mineral density (BMD) in adults with cerebral palsy (CP).MethodThirty-five patients with CP participated in this study. Demographic data including gender, age, body mass index (BMI), subtype according to neuromotor type and topographical distribution, ambulatory function, and functional independence measure (FIM) were investigated. The BMD of the lumbar spine and femur were measured using Dual-energy X-ray absorptiometry, and the factors affecting BMD were analyzed.ResultsThe BMD had no significant association with factors such as gender, age, and subtype in adults with CP. However, BMI was significantly correlated with the BMD of lumbar spine and femur (p<0.05). The FIM score was also positively correlated with the BMD of femur (p<0.05). Moreover, CP patients with higher ambulatory function had significantly higher BMD of femur (p<0.05).ConclusionThese findings suggest that BMI and functional levels such as FIM and ambulatory function can affect BMD in adults with CP. The results might be used as basic data, suggesting the importance of treatment including weight bearing exercise and gait training in adults with CP.

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Section: Discussionmentioning

confidence: 64%

Factors Affecting Bone Mineral Density in Adults with Cerebral Palsy

Yoon

Kim

et al. 2012

Ann Rehabil Med

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“…This study found bisphosphonate therapy superior to vitamin D and calcium alone in improving BMD and preventing fractures in this epileptic population [Lazzari et al 2013]. Similarly, bisphosphonates with calcium and vitamin D supplementation improves BMD in children with cerebral palsy on chronic AED therapy [Iwasaki et al 2012]. Larger randomized studies are needed to validate the prophylactic use of bisphosphonates in AED users, especially in younger patients.…”

Section: Antiepileptic Drugsmentioning

confidence: 99%

Medication-induced osteoporosis: screening and treatment strategies

Panday

Gona

Humphrey

2014

Therapeutic Advances in Musculoskeletal

152

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Drug-induced osteoporosis is a significant health problem and many physicians are unaware that many commonly prescribed medications contribute to significant bone loss and fractures. In addition to glucocorticoids, proton pump inhibitors, selective serotonin receptor inhibitors, thiazolidinediones, anticonvulsants, medroxyprogesterone acetate, aromatase inhibitors, androgen deprivation therapy, heparin, calcineurin inhibitors, and some chemotherapies have deleterious effects on bone health. Furthermore, many patients are treated with combinations of these medications, possibly compounding the harmful effects of these drugs. Increasing physician awareness of these side effects will allow for monitoring of bone health and therapeutic interventions to prevent or treat drug-induced osteoporosis.

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“…In addition, sunlight exposure, which increases serum 25-hydroxy vitamin D levels, is often insufficient because outdoor activities may be limited. Low BMD, stiffness in joints, and invasive seizures can contribute to spontaneous fractures in these patients (12). The incidence of fractures in children with severe CP is 7%-9.7% per year (13).…”

Section: Introductionmentioning

confidence: 99%