Long-term outcomes of CT-guided percutaneous cryoablation of T1a and T1b renal cell carcinoma

Spiliοpoulos, Stavros; Marzoug, Abdelaziz; Ra, Hae; Ragupathy, SK Arcot

doi:10.5152/dir.2021.20342

Cited by 7 publications

(4 citation statements)

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“…For cT1b, the results were: 77.78%, 92.68%, 93.8%, 93.7% for OS, RFS, DSS and MFS, respectively. Which, when compared to the work of Aron et al 2010 [ 49 ] with OS, RFS, DSS and MFS results of 84%, 87%, 89% and 89% for cT1a, presents results in favor of the more recent work [ 15 , 16 , 26 , 27 , 28 , 34 ], presented in our review.…”

Section: Discussioncontrasting

confidence: 60%

The Role of Focal Therapy and Active Surveillance for Small Renal Mass Therapy

2022

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Small and low-grade renal cell carcinomas have little potential for metastasis and disease-related mortality. As a consequence, the main problem remains the use of appropriately tailored treatment for each individual patient. Surgery still remains the gold standard, but many clinicians are questioning this approach and present the advantages of focal therapy. The choice of treatment regimen remains a matter of debate. This article summarizes the current treatment options in the management of small renal masses.

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Section: Discussioncontrasting

confidence: 60%

The Role of Focal Therapy and Active Surveillance for Small Renal Mass Therapy

2022

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“…Percutaneous ablation is a recommended alternative treatment for renal-cell carcinoma [8] . Radiofrequency ablation and cryoablation have shown good long-term results for early tumors [9] . However, microwave ablation is increasingly used and has slightly better technical and local tumor control rates compared to other methods, with lower major complication rates [10] .…”

Section: Discussionmentioning

confidence: 99%

Combined therapy for managing a clear cell renal cell carcinoma in a horseshoe kidney: A case report

Mejía-Quiñones,

García-Pretelt,

Holguín-Holguín

et al. 2024

Radiology Case Reports

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“…In recent years, surgeons, physicians, and researchers have collaborated to enhance the use of surgical techniques and novel chemotherapeutic interventions ( Bibok et al, 2021 ). However, complexities in local relapse and in distant metastasis are inevitable for some ccRCC patients, which seriously affects their survival interval and prognoses ( Spiliopoulos et al, 2021 ). Therefore, it is very necessary to explore novel molecular markers and therapeutic targets for predicting the clinical outcome of ccRCC patients, preventing disease progression, and even completely curing ccRCC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma

Zhang²,

Shen

et al. 2023

Front. Genet.

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Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma (ccRCC) is still unclear. The study aimed to investigate the roles and mechanisms of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma.Methods: The level of cytoskeleton-associated protein 2-like protein in tumors was explored by using UALCAN and Oncomine databases. Gene expression datasets of clear cell renal cell carcinoma from The Cancer Genome Atlas and Gene Expression Omnibus (GEO) were also used to validate the cytoskeleton-associated protein 2-like protein level in clear cell renal cell carcinoma. Survival analysis was performed to investigate the relationship between cytoskeleton-associated protein 2-like protein level and prognosis of clear cell renal cell carcinoma patients. Cox regression analysis was used for identifying the independent prognostic factors. Gene set enrichment analysis (GSEA), gene set variation analysis (GSVA), protein–protein interaction analysis, co-expression analysis, and immune infiltration analysis were used to explore the potential mechanisms of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma. Moreover, the levels of cytoskeleton-associated protein 2-like protein in clinical clear cell renal cell carcinoma tissues were also measured using RT-PCR, immunohistochemical analysis, and Western blotting. M1 macrophages and CD4+ T cells were also detected by immunohistochemistry between tumor and normal tissues.Results: The level of cytoskeleton-associated protein 2-like protein was upregulated in clear cell renal cell carcinoma according to multiple databases and experimental verification. Upregulated cytoskeleton-associated protein 2-like protein is an independent prognostic factor, which might activate the JAK–STAT signaling pathway, the P53 signaling pathway, the TGF-β signaling pathway, the WNT signaling pathway, etc., in clear cell renal cell carcinoma. Protein–protein interaction analysis and co-expression analysis suggest that cytoskeleton-associated protein 2-like protein might interact with some proliferation proteins. Immune infiltration analysis indicates that cytoskeleton-associated protein 2-like protein may affect the level of activated CD4+ memory T cells, M1 macrophages, CD8+ T cells, and neutrophils in clear cell renal cell carcinoma. More M1 macrophage infiltrations in tumor tissues with higher cytoskeleton-associated protein 2-like protein were validated by clear cell renal cell carcinoma tumor tissues.Conclusion: Cytoskeleton-associated protein 2-like protein is upregulated in clear cell renal cell carcinoma tissues, which may promote progression of the disease. Cytoskeleton-associated protein 2-like protein is a potential target for prognostic markers and a potential treatment target in clear cell renal cell carcinoma.

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Long-term outcomes of CT-guided percutaneous cryoablation of T1a and T1b renal cell carcinoma

Cited by 7 publications

References 0 publications

The Role of Focal Therapy and Active Surveillance for Small Renal Mass Therapy

The Role of Focal Therapy and Active Surveillance for Small Renal Mass Therapy

Combined therapy for managing a clear cell renal cell carcinoma in a horseshoe kidney: A case report

Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma

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