Long-term outcomes of diabetic patients undergoing endovascular infrainguinal interventions

Abularrage, Christopher J.; Conrad, Mark F.; Hackney, Lauren A.; Paruchuri, Vikram; Crawford, Robert S.; Kwolek, Christopher J.; LaMuraglia, Glenn M.; Cambria, Richard P.

doi:10.1016/j.jvs.2010.03.015

Cited by 60 publications

(26 citation statements)

References 36 publications

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“…Although surgical bypass grafting is the gold standard, acceptable midterm secondary patency and limb salvage rates have led us to consider percutaneous transluminal angioplasty (PTA) as the first-line treatment for patients with lower extremity ischemia (Abularrage et al 2010). Successful revascularization of the lower limbs by PTA can improve patients' quality of life and functional status and decrease future atherothrombotic events (Giugliano et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model

Zhou¹,

Dong²,

Zhang³

et al. 2014

Journal of Endocrinology

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It is well known that hyperglycemia is a trigger of atherosclerosis in patients with diabetes mellitus. However, the role of hyperglycemia in restenosis remains unclear. In this study, we investigated the effects of hyperglycemia on restenosis. Stenosis was evaluated in two sets of diabetic rabbit models: i) diabetic restenosis versus nondiabetic restenosis and ii) diabetic atherosclerosis versus nondiabetic atherosclerosis. Our results indicated that there was no difference in rates of stenosis between the diabetic and the nondiabetic groups in restenosis rabbit models. However, the incidence of stenosis was significantly higher in the diabetic atherosclerosis group compared with the nondiabetic atherosclerosis group. Similarly, the intima-media thickness and cell proliferation rate were significantly increased in the diabetic atherosclerosis group compared with the nondiabetic atherosclerosis group, but there was no difference between the diabetic restenosis and the nondiabetic restenosis groups. Our results indicate that hyperglycemia is an independent risk factor for atherosclerosis, but it has no evident effect on restenosis. These findings indicate that the processes of atherosclerosis and restenosis may involve different pathological mechanisms.

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Section: Introductionmentioning

confidence: 99%

Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model

Zhou¹,

Dong²,

Zhang³

et al. 2014

Journal of Endocrinology

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“…Our registry study is one of the first to describe such patients [9][10]. In the current analysis we tried to predict outcome in diabetic patients which are known to have poor survival not only after coronary PCI procedures but also after PTA [8,12].…”

Section: Discussionmentioning

confidence: 99%

“…It is quite common that the atherosclerosis coexists in many arterial beds -in coronary artery disease patients in up to 30% of the cases. The presence of diabetes has also predicted poor outcome after lower limb percutaneous transluminal angioplasty (PTA) [8]. There are still insufficient data concerning long-term clinical outcome for patients with diabetes treated with PTA, especially in the setting of ACS.…”

Section: Introductionmentioning

confidence: 99%

Long-term follow-up of percutaneous peripheral interventions in lower limb arteries in patients with acute coronary syndrome and diabetes

Bartuś¹,

Siudak²,

Chyrchel³

et al. 2010

pwki

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A b s t r a c tBackground: Diabetes mellitus is a quite frequent comorbidity among patients with acute coronary syndromes (ACS). The presence of diabetes has also predicted poor outcome after lower limb percutaneous transluminal angioplasty (PTA).Aim: To determine outcomes of patients with and without diabetes mellitus treated with PCI and PTA at index hospital stay during a 12-month follow-up.Material and methods: There were 116 NSTACS (non ST elevation acute coronary syndromes) patients gathered in this prospective registry study in [2003][2004][2005][2006][2007][2008][2009] in one academic center in Krakow, Poland.Results: Data on consecutive patients who underwent PTA and PCI procedure during the same hospital stay were analyzed. Of these, 16 (14%) had diabetes mellitus, the other 100 (86%) had no history of diabetes. Both groups differed significantly with regard to gender and past medical history. During one-year observation 12.5% patients died in diabetes group vs. 2% in non-diabetes group (p = 0.033). Diabetes mellitus has turned out to be a strong predictor of outcome measured by the occurrence of repeated percutaneous peripheral procedure in 12-month observation.Conclusions: Patients with diabetes mellitus have more aggravating past medical history with more frequently coexisting comorbidities. Diabetes mellitus in patients with ACS treated by PCI and PTA is associated with impaired 1-year survival. Diabetes itself is a strong predictor of repeated PTA procedures.Key words: peripheral angioplasty, diabetes, acute coronary syndrome, limb ischaemia S t r e s z c z e n i e Wstęp: Współwystępowanie cukrzycy i ostrych zespołów wieńcowych (OZW) jest częstym zjawiskiem. Obecność cukrzycy jest predyktorem niekorzystnego rokowania chorych po zabiegach przezskórnej angioplastyki tętnic kończyn dolnych (ang. percutaneous transluminal angioplasty, PTA).Cel: Porównanie bezpośrednich wyników leczenia chorych z cukrzycą i bez cukrzycy metodą przezskórnej interwencji wieńcowej (ang. percutaneous coronary intervention, PCI) oraz PTA w czasie tej samej hospitalizacji oraz określenie wyników leczenia w 12-miesięcznej obserwacji.Materiał i metody: Stu szesnastu chorych z OZW bez uniesienia odcinka ST zostało włączonych do prospektywnego rejestru w czasie badania w latach 2003-2009 w jednym centrum akademickim w Krakowie.Wyniki: Analizowano dane chorych, którzy przebyli procedury PCI i PTA w czasie jednego pobytu szpitalnego. Spośród tych chorych 16 (14%) miało rozpoznaną cukrzycę, pozostali nie byli leczeni z tego powodu [100 (86%)]. Obie grupy różniły się istotnie statystycznie ze względu na płeć i wywiad. W ciągu rocznej obserwacji 12,5% osób zmarło w grupie chorych na cukrzycę w przeciwieństwie do 2% zgonów w grupie chorych bez cukrzycy (p = 0,033). Cukrzyca okazała się również silnym czynnikiem konieczności wykonania ponownych interwencji przezskórnych w ciągu 12-miesięcznej obserwacji.

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“…Our infrainguinal interventional technique has been reported previously. 19 In brief, all infrainguinal interventions were performed by a team of vascular surgeons who satisfied the Massachusetts General Hospital Vascular Center credentialing and Society for Vascular Surgery criteria for performance of endovascular procedures. Selective angiography was performed under local anesthesia and systemic heparin, with a target activated clotting time of 200 to 250 seconds.…”

Section: Methodsmentioning

confidence: 99%

Long-term outcomes of patients undergoing endovascular infrainguinal interventions with single-vessel peroneal artery runoff

Abularrage

Conrad

Haurani

et al. 2011

Journal of Vascular Surgery

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Long-term outcomes of diabetic patients undergoing endovascular infrainguinal interventions

Cited by 60 publications

References 36 publications

Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model

Hyperglycemia has no effect on development of restenosis after percutaneous transluminal angioplasty (PTA) in a diabetic rabbit model

Long-term follow-up of percutaneous peripheral interventions in lower limb arteries in patients with acute coronary syndrome and diabetes

Long-term outcomes of patients undergoing endovascular infrainguinal interventions with single-vessel peroneal artery runoff

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