2011
DOI: 10.1007/s00431-010-1390-5
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Long-term outcomes of pneumococcal meningitis in childhood and adolescence

Abstract: A vaccine to prevent pneumococcal meningitis (PM) has recently been introduced. However, contemporary data to inform cost-effectiveness analysis and justify its routine use are sparse. We examined the cognitive, educational, psychological and social outcomes of PM in childhood. We completed a population-based case-control study in two regions of the UK. Children and young people currently between 3 and 20 years of age that had been diagnosed with PM ≤14 years of age were identified from active regional surveil… Show more

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Cited by 37 publications
(21 citation statements)
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“…These results corroborate the findings of prior studies in children with these disorders (16)(17)(18)(19)(20)(21).…”
Section: Discussionsupporting
confidence: 83%
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“…These results corroborate the findings of prior studies in children with these disorders (16)(17)(18)(19)(20)(21).…”
Section: Discussionsupporting
confidence: 83%
“…Discrepancies may be related to differences in inclusion criteria; length of follow-up; and use or not of healthy controls. Cognitive sequelae have been identified in sub-groups of acutely ill children, including meningitis (16)(17)(18)(19), sepsis or septic shock (7,20,21), and meningococcal disease (22,23).…”
Section: Introductionmentioning
confidence: 99%
“…There are limited robust data about QALY losses associated with sequelae in children, but efforts are being made to get more reliable data. 26 We excluded QALY losses associated with acute forms of disease or minor vaccine-related adverse events, because of the limited duration of these events and accurate estimates of QALY losses associated with such acute events in children are lacking.…”
Section: Resultsmentioning
confidence: 99%
“…Short and long-term neurocognitive abnormalities including decreased verbal IQ are well documented following early life CNS infections (Christie et al, 2011). Neurological complications have also been reported to accompany systemic infections (Khandaker et al, in press).…”
Section: Discussionmentioning
confidence: 99%