2020
DOI: 10.1093/ejcts/ezaa042
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Long-term outcomes of upfront surgery in patients with resectable pathological N2 non-small-cell lung cancer

Abstract: OBJECTIVES Although the standard treatment for pathological N2 (pN2) non-small-cell lung cancer (NSCLC) patients is definitive chemoradiation, surgery can be beneficial for resectable pN2 disease. Herein, we report the long-term clinical outcomes of upfront surgery followed by adjuvant treatment for selected patients with resectable pN2 disease. METHODS We performed a retrospective analysis of clinical outcomes for patients w… Show more

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Cited by 34 publications
(32 citation statements)
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“…According to multivariable Cox analysis, the VATS approach was not a significant prognostic factor of OS and RFS among patients with cN2 disease. www.nature.com/scientificreports/ In our institution, upfront surgical resection followed by adjuvant therapy has been prospectively performed for patients with resectable N2 disease for 20 years 15 . Initially, open thoracotomy was usually performed for these patients.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…According to multivariable Cox analysis, the VATS approach was not a significant prognostic factor of OS and RFS among patients with cN2 disease. www.nature.com/scientificreports/ In our institution, upfront surgical resection followed by adjuvant therapy has been prospectively performed for patients with resectable N2 disease for 20 years 15 . Initially, open thoracotomy was usually performed for these patients.…”
Section: Discussionmentioning
confidence: 99%
“…In our institution, upfront surgical resection followed by adjuvant therapy has been prospectively performed for patients with resectable N2 disease for 20 years 15 . Initially, open thoracotomy was usually performed for these patients.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Yun et al [84] recently reported their outcomes of upfront surgery followed by adjuvant treatment for resectable N2 diseases. Following the previously described IASCL subdivision of lymph nodes, they found similar results to those of Asamura: patients with pN2a1 had excellent survival outcomes, similar to stage II patients (5YOS 58.0%) when compared to pN2a2 (5YOS 46.2%, p = 0.032) and pN2b (5YOS 39.0%, p = 0.0006); moreover, the addition of RT to postoperative chemotherapy, had positive prognostic effect for patients with pN2b (5YOS 47.0% vs 27.9%, p = 0.013).…”
Section: Single or Multiple-station N2mentioning
confidence: 99%