Long-term Outcomes on Lens Clarity after Lens-Sparing Vitrectomy for Retinopathy of Prematurity

Nudleman, Eric; Robinson, Joshua; Rao, Prethy; Drenser, Kimberly A.; Capone, Antonio; Trese, Michael T.

doi:10.1016/j.ophtha.2014.11.004

Cited by 47 publications

(48 citation statements)

References 33 publications

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“…26 In addition, myopia, strabismus, and amblyopia also occur frequently. 27,28 The pathogenesis of ROP is multifactorial: besides prematurity and low birth weight, factors such as high-concentration oxygen therapy and suboptimal postnatal nutrition could put infants at significant risk for this devastating eye disease, as established by clinical studies and animal studies. 9,29 The meta-analysis results of our study indicate that the overall incidence of ROP was reduced among infants fed human milk compared with those fed formula, and exclusive or mainly human milk feeding showed significant benefits in preventing severe ROP.…”

Section: Discussionmentioning

confidence: 99%

Human Milk Feeding as a Protective Factor for Retinopathy of Prematurity: A Meta-analysis

Zhou

Shukla

John³

et al. 2015

Pediatrics

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CONTEXT: Studies have suggested that human milk feeding decreases the incidence of retinopathy of prematurity (ROP); however, conflicting results have been reported. OBJECTIVE:The aim of this meta-analysis was to pool currently available data on incidence of ROP in infants fed human milk versus formula.DATA SOURCES: Medline, PubMed, and EBSCO were searched for articles published through February 2015.STUDY SELECTION: Longitudinal studies comparing the incidence of ROP in infants who were fed human milk and formula were selected. Studies involving donor milk were not included.DATA EXTRACTION: Two independent reviewers conducted the searches and extracted data. Metaanalysis used odds ratios (ORs), and subgroup analyses were performed.RESULTS: Five studies with 2208 preterm infants were included. Searches including various proportions of human milk versus formula, any-stage ROP, and severe ROP were defined to pool data for analyses. LIMITATIONS: Prospective randomized studies being impossible because of ethical issues, we chose observational studies for analysis. A few studies involving subgroup analyses presented high heterogeneity.CONCLUSIONS: Based on current limited evidence, in very preterm newborns, human milk feeding potentially plays a protective role in preventing any-stage ROP and severe ROP.

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Section: Discussionmentioning

confidence: 99%

Human Milk Feeding as a Protective Factor for Retinopathy of Prematurity: A Meta-analysis

Zhou

Shukla

John³

et al. 2015

Pediatrics

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“…Once an advancing stage 4 detachment is diagnosed, treatment with lens sparing vitrectomy (LSV) is recommended. In one large series, the reattachment rate after one LSV was 82% for stage 4A disease, 70% for stage 4B, and 43% for stage 5 47. Scleral buckles can also be used in the treatment of ROP detachments but often need to be divided to avoid significant induced refractive changes.…”

Section: Treatmentmentioning

confidence: 99%

Current screening and treatments in retinopathy of prematurity in the US

Suelves

Shulman

2016

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Retinopathy of prematurity (ROP) is a complex disease characterized by an aberrant developmental retinal angiogenesis in preterm infants and can carry significant visual morbidity, including retinal detachment and blindness. Though large scale, randomized clinical trials have improved our understanding of the pathophysiology and progression of the disease, the management of ROP remains a challenge for ophthalmologists. This review addresses the up-to-date screening approach, diagnosis, and treatment guidelines for ROP in the US.

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“…When progressive stage 4 ROP develops, a lens-sparing vitrectomy can be effective to prevent stage 5 ROP(120) and preserve the lens for visual rehabilitation of the infant. Although scleral buckling plays a role, lens-sparing vitrectomy has been reported to be more effective in addressing surgical goals in Zone I or Zone II progressive Stage 4 ROP.…”

Section: Change In Clinical Concepts Diagnosis and Management Imentioning

confidence: 99%

Advances in understanding and management of retinopathy of prematurity

Hartnett

2017

Survey of Ophthalmology

116

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The understanding, diagnosis and treatment of retinopathy of prematurity (ROP) have changed in the last seventy years since the original description of retrolental fibroplasia associated with high oxygenation. It is now recognized that ROP differs in appearance world-wide and as ever smaller and younger premature infants survive. New methods are being evaluated to image the retina, diagnose severe ROP, and determine windows of time for treatment to save eyes and improve visual and neural outcomes. New treatments to promote physiologic retinal vascular development, vascular repair, and inhibit vasoproliferation by regulating proteins involved in vascular endothelial growth factor, insulin-like growth factor, or erythropoietin signaling. Reducing excessive oxidative/nitrosative stress and understanding progenitor cells and neurovascular and glial vascular interactions are being studied.

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Long-term Outcomes on Lens Clarity after Lens-Sparing Vitrectomy for Retinopathy of Prematurity

Cited by 47 publications

References 33 publications

Human Milk Feeding as a Protective Factor for Retinopathy of Prematurity: A Meta-analysis

Human Milk Feeding as a Protective Factor for Retinopathy of Prematurity: A Meta-analysis

Current screening and treatments in retinopathy of prematurity in the US

Advances in understanding and management of retinopathy of prematurity

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