Long-term persistence of hepatitis C virus antibodies in a single source outbreak

Dittmann, S; Roggendorf, Michael; Dürkop, J; Wiese, Manfred; Lorbeer, Bernd; Deinhardt, Friedrich

doi:10.1016/0168-8278(91)90076-n

Cited by 103 publications

(42 citation statements)

References 14 publications

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“…Even in recipients of batch 237, the most infectious batch, only 60% of those tested some 17 years later show serological evidence of exposure to HCV and of these only 60% are still viraemic. These findings are however in accord with a similar outbreak of HCV in Germany in 1978–1979 [18]. …”

Section: Discussionsupporting

confidence: 79%

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti–D Immunoglobulin Preparation

et al. 1999

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Background and Objectives: The aim of this study was to determine the hepatitis C virus (HCV) infection rate of recipients of different batches of anti–D immunoglobulin associated with an outbreak of HCV infection which occurred in 1977 and its relationship to the polymerase chain reaction (PCR) status of the implicated batches. This study was undertaken to determine the predictive value of HCV genome detection and quantification for subsequent infection in recipients of an HCV–contaminated anti–D immunoglobulin product for intravenous use. Materials and Methods: Sera from recipients of anti–D were tested by HCV enzyme immunoassay and if found positive were subsequently tested by recombinant immunoblot assay and HCV PCR in a national HCV anti–D screening programme set up in 1994. The HCV status of 1,342 known recipients of infectious or potentially infectious batches has been compared to the amount of HCV RNA in the anti–D batch they received so as to determine the value of PCR in the prediction of infectivity in immunoglobulin preparations. Results: It has been demonstrated that HCV–infected plasma derived from batches of anti–D showing levels of viral genome in excess of 10⁴ genomes per millilitre led to infection of up to 60% of recipients. In contrast, batches with undetectable levels of HCV genome very rarely transmitted infection. Conclusions: The presence of HCV RNA in intravenous immunoglobulin preparations which have not undergone a specific viral inactivation step is a predictor of HCV infection in recipients.

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Section: Discussionsupporting

confidence: 79%

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti–D Immunoglobulin Preparation

et al. 1999

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“…Between August 1978 and March 1979, 14 batches of the same virus-contaminated anti-D Ig had been administered to 2,867 women in East Germany for the prevention of hemolytic disease in newborns through Rhesus incompatibility, leading to a single-source outbreak of HCV infection (16). The HCV isolate obtained from one of the batches of the contaminated globulin was designated HCV-AD78 (genotype 1b) (17).…”

Section: Methodsmentioning

confidence: 99%

“…Thus, cohorts of patients with a homogenous viral inoculum derived from a single source, such as the East German hepatitis C outbreak in 1978-1979 involving a large well defined cohort of young pregnant women who received anti-D Ig contaminated with a single HCV strain (genotype 1b, isolate AD78) (16)(17)(18), represent a unique opportunity to study the impact of neutralizing antibodies for control of viral infection.…”

mentioning

confidence: 99%

Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

Pestka

Zeisel

Bläser

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

487

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In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of neutralizing responses has been hampered by the fact that patient cohorts as well as hepatitis C virus (HCV) strains are usually heterogeneous, and that clinical data from acute-phase and long-term follow-up after infection are not readily available. Using an infectious retroviral HCV pseudoparticle model system, we studied a cohort of women accidentally exposed to the same HCV strain of known sequence. In this single-source outbreak of hepatitis C, viral clearance was associated with a rapid induction of neutralizing antibodies in the early phase of infection. Neutralizing antibodies decreased or disappeared after recovery from HCV infection. In contrast, chronic HCV infection was characterized by absent or low-titer neutralizing antibodies in the early phase of infection and the persistence of infection despite the induction of cross-neutralizing antibodies in the late phase of infection. These data suggest that rapid induction of neutralizing antibodies during the early phase of infection may contribute to control of HCV infection. This finding may have important implications for understanding the pathogenesis of HCV infection and for the development of novel preventive and therapeutic antiviral strategies.vaccines ͉ pathogenesis ͉ host reponses

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“…Approximately 90% of patients develop chronic hepatitis (11), of which 20 to 30% progress to liver cirrhosis and end-stage liver disease (20,43). HCV is an enveloped positive-stranded RNA virus (8) that belongs to the Flaviviridae family.…”

mentioning

confidence: 99%

Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation

Ludwig¹,

Lekkerkerker²,

Depla

et al. 2004

J Virol

129

113

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Long-term persistence of hepatitis C virus antibodies in a single source outbreak

Cited by 103 publications

References 14 publications

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti–D Immunoglobulin Preparation

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti–D Immunoglobulin Preparation

Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation

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Long-term persistence of hepatitis C virus antibodies in a single source outbreak

Cited by 103 publications

References 14 publications

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti&ndash;D Immunoglobulin Preparation

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti&ndash;D Immunoglobulin Preparation

Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation

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Product

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Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti–D Immunoglobulin Preparation

Transmission Rates of Hepatitis C Virus by Different Batches of a Contaminated Anti–D Immunoglobulin Preparation