Long-term Persistence of Zoster Vaccine Efficacy

Abstract

Estimates of vaccine efficacy decreased over time in the LTPS population compared with modeled control estimates. Statistically significant vaccine efficacy for HZ BOI persisted into year 10 postvaccination, whereas statistically significant vaccine efficacy for incidence of HZ persisted only through year 8.

Varicella Zoster Virus: A Common Cause of Stroke in Children and Adults

“…Thus, the FDA has approved its administration in healthy adults ≥ 50 years of age, with contraindications including anaphylaxis to gelatin or neomycin, immunosuppression, immunodeficiency and pregnancy. The SPS demonstrated efficacy for 4 years after vaccination, while subsequent studies (52,53) indicated efficacy for 8 years (54). Currently, CDC does not recommend booster doses of zoster vaccine, but may in the future.…”

Background paper to the decision not to recommend a standard vaccination with the live attenuated herpes zoster vaccine for the elderly in Germany

“…In the LTPS study, parts of the cohort of the SPS and STPS studies were followed up for a period of up to 11 years after vaccination [39]. The study was conducted from March 2006 to December 2010.…”

Varicella zoster virus infection

“…In additional substudies 159,160 , efficacy for burden of disease persisted for 10 years after vaccination but efficacy for the incidence of zoster persisted only for 8 years 160 . The CDC currently does not recommend booster doses of the zoster vaccine, but it might do in the future.…”