Long-term physical training increases liver IGF-I in diabetic rats

Leme, José Alexandre C.A; Silveira, Ricardo dos Reis; Gomes, Ricardo José; Moura, Rodrigo Ferreira de; Sibuya, C.A.; Mello, María Alice Rostom de; Luciano, Eliete

doi:10.1016/j.ghir.2008.12.004

Cited by 22 publications

(18 citation statements)

References 59 publications

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“…Therefore, regular exercise can infl uence glucose homeostasis in rats subjected to neonatal administration of alloxan, by increasing muscle glucose uptake and oxidation. Glucose utilization is synergistically stimulated by exercise training and insulin, and chronic exercise induces a decrease in the blood glucose levels of diabetic rats [43,44]. The mechanisms that locally act to improve glucose uptake are increased muscle blood fl ow, insulin binding to its receptor (the insulin receptor, IR), IR turnover, stimulated AMPK (adenosine monophosphate-activated protein kinase), AS160 (AKT substrate) and increased glucose transport by stimulating GLUT4 translocation to the muscle cell surface [43,45].…”

Section: Discussionmentioning

confidence: 99%

Continuous and Intermittent Exercise Training and Glucose Metabolism in Neonatal Alloxan Administered Rats

Ribeiro

2011

J Endocrinol Metab

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Section: Discussionmentioning

confidence: 99%

Continuous and Intermittent Exercise Training and Glucose Metabolism in Neonatal Alloxan Administered Rats

Ribeiro

2011

J Endocrinol Metab

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“…Prévios estudos demonstraram que o exercício físico crônico de natação, realizado na intensidade de transição metabólica aeróbia/anaeróbia em ratos, causa alterações relevantes no eixo GH/IGF (Gomes et al, 2006;Leme, Gomes, Mello, & Luciano, 2007 Os animais foram alojados em gaiolas de polietileno (5 ratos por gaiola), mantidos à temperatura ambiente de 25º C e fotoperíodo de 12 horas de claro/12 horas de escuro e alimentados com ração balanceada padrão Purina® e água "ad libitum".…”

Section: Effect Of Oral Arginine Supplementation On Gh Secretion and unclassified

Efeito da suplementação oral de arginina sobre a secreção de GH e metabolismo de lipídios em ratos Wistar treinados

Chiyoda¹,

Nakamura²,

Codogno³

et al. 2009

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A Suplementação Oral de Arginina (SOA) e o exercício físico são capazes de modificar a secreção do Hormônio de Crescimento (GH), interferindo no metabolismo lipídico. O objetivo do estudo foi verificar o efeito da SOA, do exercício físico aeróbio e a combinação da suplementação com o exercício sobre a secreção de GH e metabolismo lipídico em ratos. A amostra foi composta por 40 ratos machos da linhagem Wistar, divididos em grupos Controle Sedentário (CS), Arginina Sedentário (AS), Controle treinado (CT) e Arginina Treinado (AT). O AS e AT receberam a suplementação oral de arginina em dias alternados e os CT e AT realizaram exercícios de natação por 1 hora/dia com sobrecarga equivalente à 5% do peso corporal 5 dias por semana durante 4 semanas. Em conclusão, os resultados demonstram que o treinamento físico aeróbio não alterou o metabolismo lipídico e diminuiu os valores séricos de GH e a SOA não alterou a concentração de GH em ratos Wistar.Palavras-chave: suplementação oral, metabolismo lipídico, exercício aeróbio, hormônio de crescimento Submetido: 09

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“…Furthermore, in the case of physiological disorders such as Diabetes Mellitus, GH can contribute to an increase in IGF-1 (Leme et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Morphometric Study of Muscle Fibers in Rats Submitted to Strength Training and Growth Hormone

et al. 2017

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SUMMARY:The aim of the present study was to observe the changes in the muscle tissue of rats after application of growth hormone (GH) and performing a strength training protocol (ST). In total, 40 male Wistar rats, 60 days old, were used, divided into four groups: control (C), control and application of GH (GHC), strength training (T), and strength training with the application of GH (GHT). The physical training protocol (PT) was composed of four series of 10 jumps in water, 3x/week, with an overload of 50 % of body weight for four weeks. GH was administered intraperitoneally at a dose of 0.2 IU/Kg to the GHC and GHT groups and saline (0.9 % sodium chloride) to the C and T groups. After four weeks of PT, the animals were euthanized and samples taken from the Soleus muscle. Histological sections were produced with a thickness of 5 mm and stained with hematoxylin-eosin (HE) and nicotinamide adenine dinucleotide tetrazolium reductase (NADH-TR). The markings for determining the measurement of the smallest diameter of muscle fibers (MF) were carried out using the software (AuxioVisionRel 4.8-Carl Zeiss ® and NIS-Elements D3.0-SP7-Nikon ® ). After obtaining the data, the Shapiro-Wilk test for normality was performed and then the nonparametric Kruskal-Wallis with Dunn post-test were used for analysis of MF and the Student t test for the analysis of intragroup body weights. All procedures adopted a 5 % significance value (p <0.05) and were performed using the software SPSS 22.0 for Windows ® . It was observed that both the GH and PT were able to generate increased diameter of MF (C:31.81±6.35; GHC:36.88±6.38; T:38.38± 6.94; GHT:36.89±7.16). Moreover, when analyzing the type, a significant increase was found only in the fast twitch MF (C:33.78±7.78; GHC:37.80±6.03; T:38.53±6.94; GHT:37.98±7.65) when compared to the slow twitch (C:25.93±6.66; GHC:26.95±8.03; T:26.24±6.90; GHT:27.20±5.77).

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Long-term physical training increases liver IGF-I in diabetic rats

Cited by 22 publications

References 59 publications

Continuous and Intermittent Exercise Training and Glucose Metabolism in Neonatal Alloxan Administered Rats

Continuous and Intermittent Exercise Training and Glucose Metabolism in Neonatal Alloxan Administered Rats

Efeito da suplementação oral de arginina sobre a secreção de GH e metabolismo de lipídios em ratos Wistar treinados

Morphometric Study of Muscle Fibers in Rats Submitted to Strength Training and Growth Hormone

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