Long-term physico-chemical stability of standard parenteral nutritions for neonates

Bouchoud, Lucie; Sadeghipour, Farshid; Klingmüller, Martin; Fonzo-Christe, Caroline; Bonnabry, Pascal

doi:10.1016/j.clnu.2010.04.004

Cited by 22 publications

(32 citation statements)

References 19 publications

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“…The influence of packaging on the stability of parenteral nutrition mixture was also studied [10, 11]. It was found that storage time and temperature as well as exposure to light had the greatest effect on the stability of parenteral nutrition mixtures.…”

Section: Methods Of Parenteral Nutrition Analysismentioning

confidence: 99%

“…Both assays can be done directly, without any initial extractions, using commercial tests. The hexokinase method was used successfully by Bouchoud et al [11]. If an assay indicates a lowered concentration of glucose in the parenteral nutrition than expected, a reaction between some amino acid (lysine, histidine, or cysteine) and glucose can be suspected.…”

Section: Methods Of Parenteral Nutrition Analysismentioning

confidence: 99%

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Pharmaceutical Point of View on Parenteral Nutrition

Stawny

Olijarczyk

Jaroszkiewicz

et al. 2013

The Scientific World Journal

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Parenteral nutrition—a form of administering nutrients, electrolytes, trace elements, vitamins, and water—is a widely used mode of therapy applied in many diseases, in patients of different ages both at home and in hospital. The success of nutritional therapy depends chiefly on proper determination of the patient's energetic and electrolytic needs as well as preparation and administration of a safe nutritional mixture. As a parenterally administered drug, it is expected to be microbiologically and physicochemically stable, with all of the components compatible with each other. It is very difficult to obtain a stable nutritional mixture due to the fact that it is a complex, two-phase drug. Also, the risk of incompatibility between mixture components and packaging should be taken into consideration and possibly eliminated. Since parenteral nutrition is a part of therapy, simultaneous use of drugs may cause pharmacokinetic and pharmacodynamic interactions as well as those with the pharmaceutical phase. The aim of this paper is to discuss such aspects of parenteral nutrition as mixture stability, methodology, and methods for determining the stability of nutritional mixtures and drugs added to them.

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Section: Methods Of Parenteral Nutrition Analysismentioning

confidence: 99%

Section: Methods Of Parenteral Nutrition Analysismentioning

confidence: 99%

Pharmaceutical Point of View on Parenteral Nutrition

Stawny

Olijarczyk

Jaroszkiewicz

et al. 2013

The Scientific World Journal

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“…Water and fat soluble vitamins (Soluvit and Vitalipid 10%) are added to the lipid emulsion to increase the vitamin stability [82]. Table 2 shows the amount of vitamins supplied to infants through the proposed lipid emulsion when run at 3 g/kg/day.…”

Section: Consensus Aa/dextrose Formulationsmentioning

confidence: 99%

Standardised neonatal parenteral nutrition formulations – an Australasian group consensus 2012

et al. 2014

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Standardised parenteral nutrition formulations are routinely used in the neonatal intensive care units in Australia and New Zealand. In 2010, a multidisciplinary group was formed to achieve a consensus on the formulations acceptable to majority of the neonatal intensive care units. Literature review was undertaken for each nutrient and recommendations were developed in a series of meetings held between November 2010 and April 2011. Three standard and 2 optional amino acid/dextrose formulations and one lipid emulsion were agreed by majority participants in the consensus. This has a potential to standardise neonatal parenteral nutrition guidelines, reduce costs and prescription errors.

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“…From February 2009 the pharmacy produced standard PN solution for the first 5 days of life of premature newborns 8. The availability of these new PNs decreased the number of prescriptions for individual PN 9.…”

Section: Introductionmentioning

confidence: 99%

Validation of a once-a-week set up for an automated compounder device for parenteral nutrition solutions

et al. 2013

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Background Setting up an automated compounder device (ACD) takes time and money. Daily production of paediatric parenteral nutrition (PN) solutions in our pharmacy decreased after implementing standard PN for neonatology. To keep the production of a limited number of PN bags cost effective, we wished to set up the ACD weekly rather than daily. Objectives This study aims to validate (operational and performance qualification (PQ)) use of an ACD (Baxa MM12) for once-a-day and once-a-week set up. Methods Accuracy and precision of the ACD were evaluated using water (operational qualification) on a daily basis, and using the products for preparing PN solutions (PQ) on a daily and a weekly basis. Nutrient dosage was measured for specific PN solutions after daily or weekly ACD set ups. Particle contamination of PN solutions produced were controlled throughout the week. To validate the aseptic process, media-fill tests of the once-a-week set ups were carried out over three consecutive weeks. Results Accuracy and precision of the ACD were validated for small (0.5 ml) and high (100 ml) volumes. Precision improved when pumped volumes increased. Nutrient dosage in PN solutions following daily and weekly set ups were always in conformity with specification limits. No particles or microbiological contaminations were detected following the week-long set ups. Conclusions Validation proved good accuracy, precision and aseptic conditions existed throughout each week. PN solutions can be produced safely all week long with one set up. A week-long set up saves technician time and money.

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Long-term physico-chemical stability of standard parenteral nutritions for neonates

Cited by 22 publications

References 19 publications

Pharmaceutical Point of View on Parenteral Nutrition

Pharmaceutical Point of View on Parenteral Nutrition

Standardised neonatal parenteral nutrition formulations – an Australasian group consensus 2012

Validation of a once-a-week set up for an automated compounder device for parenteral nutrition solutions

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