Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus

Harashima, Keiichiro; Hoshino, Junichi; Miwa, Takashi; Tsunoda, Tooru

doi:10.1016/j.metabol.2008.09.015

Cited by 30 publications

(21 citation statements)

References 36 publications

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“…[25][26][27][28] However, although the frequency of use of these medications differed in the two groups in this study, no significant correlation between CAVI and the frequency of use of these medications was observed in the entire study group. Possible explanations for this result are that (1) as the majority of our study subjects were taking at least one of these medications, the interindividual variability of the effect of those medications on CAVI might have been small, (2) this study differed from previous studies [25][26][27][28] in that all our study subjects had significant CAD and several coronary risk factors, which might have resulted in an even smaller favorable effect on arterial stiffness with such medications in this study as compared with previous studies.…”

Section: Discussioncontrasting

confidence: 62%

Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris

et al. 2010

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We aimed to evaluate whether there was a difference in the arterial stiffness assessed by the cardio-ankle vascular index (CAVI) between patients with acute coronary syndrome (ACS) and those with stable angina pectoris (SAP). A total of 199 consecutive patients, 79 with ACS and 120 with SAP, who underwent emergency or elective coronary revascularization were enrolled. The CAVI was measured within 2 days after the procedures, and was compared between the ACS and SAP patients. As parameters related to arteriosclerosis, carotid intima-media thickness (IMT) and number of stenotic coronary vessels were also evaluated. Although IMT was significantly greater in SAP patients (2.1 ± 1.1 vs. 2.4 ± 0.9; P¼0.022), CAVI was significantly higher in ACS patients (10.0±1.7 vs. 9.3±1.3; P¼0.0012). After an adjustment for the clinical parameters with a significant difference between the two patient groups, CAVI remained significantly higher in ACS patients than in SAP patients (odds ratio 1.92, 95% confidence interval 1.30-3.02; P¼0.0023). A multiple linear regression analysis revealed that age (b¼0.44; Po0.0001) and ACS (b¼0.3; Po0.0001) were the independent determinants of CAVI. A significant decrease in CAVI was observed at 6 months of follow-up as compared with the acute phase in 18 patients with ACS (10.9±1.6 vs. 10.0±1.5; P¼0.019). In conclusion, CAVI was significantly and independently higher in patients with ACS than in those with SAP, which might result from a transient increase in the CAVI caused by acute myocardial ischemia.

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Section: Discussioncontrasting

confidence: 62%

Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris

et al. 2010

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“…In the pioglitazone group, compared to other groups, fewer patients used antihypertensive medications to achieve normal peripheral blood pressure. This finding could reflect independence of pioglitazone on antihypertensive therapies 83 . Acarbose treatment reduces the risk of cardiovascular disease by altering the arterial stiffness in the postprandial hyperglycaemic status in patients with type 2 diabetes.…”

Section: Peroral Antidiabetic Drugsmentioning

confidence: 88%

Pulse wave analysis and diabetes mellitus. A systematic review

Gajdova

Karásek

Goldmannová

et al. 2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Cardiovascular (CV) disease is the primary cause of death in diabetic patients and one of the explanations may be increased arterial stiffness. Arterial stiffness assessment using pulse wave analysis, is a predictive factor of CV events. The aim of this paper is to review the current knowledge of relations between diabetes mellitus and pulse wave analysis. A MEDLINE search was performed to retrieve both original and review articles addressing the relations and influences on arterial stiffness in diabetics. Pulse wave analysis is considered as a gold standard in CV risk evaluation for patients at risk, especially diabetics. Arterial stiffness assessment may be helpful for choosing more aggressive diagnostic and therapeutic strategies, particularly in younger patients to reduce the incidence of CV disease in these patients.

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“…Treatment with glitazones, peroxisome proliferator-activated receptor gamma (PPAR- γ ) agonists, was shown not only to improve insulin resistance and glycemic control, but also to decrease arterial stiffness in patients with type 2 diabetes mellitus [64, 100, 101]. PPAR receptors were also proven to be expressed in the vascular tissue and influence vascular homeostasis [118].…”

Section: Influence Of Drugs On Arterial Stiffnessmentioning

confidence: 99%

Arterial Stiffness and Cardiovascular Therapy

Janić

Lunder

Šabovič

2014

BioMed Research International

121

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The world population is aging and the number of old people is continuously increasing. Arterial structure and function change with age, progressively leading to arterial stiffening. Arterial stiffness is best characterized by measurement of pulse wave velocity (PWV), which is its surrogate marker. It has been shown that PWV could improve cardiovascular event prediction in models that included standard risk factors. Consequently, it might therefore enable better identification of populations at high-risk of cardiovascular morbidity and mortality. The present review is focused on a survey of different pharmacological therapeutic options for decreasing arterial stiffness. The influence of several groups of drugs is described: antihypertensive drugs (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, diuretics, and nitrates), statins, peroral antidiabetics, advanced glycation end-products (AGE) cross-link breakers, anti-inflammatory drugs, endothelin-A receptor antagonists, and vasopeptidase inhibitors. All of these have shown some effect in decreasing arterial stiffness. Nevertheless, further studies are needed which should address the influence of arterial stiffness diminishment on major adverse cardiovascular and cerebrovascular events (MACCE).

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Long-term pioglitazone therapy improves arterial stiffness in patients with type 2 diabetes mellitus

Cited by 30 publications

References 36 publications

Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris

Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris

Pulse wave analysis and diabetes mellitus. A systematic review

Arterial Stiffness and Cardiovascular Therapy

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