Long‐term post‐treatment follow‐up of onychomycosis treated with terbinafine: a multicentre trial

Abstract

Between 1991 and 1993, 32 cases of fingernail mycosis and 20 cases of toenail mycosis caused by dermatophytes were treated with terbinafine. For 8 weeks, 250 mg of terbinafine was given daily for fingernail infections, and for 12 weeks the same dose was given for toenail involvement; the short-term follow-up was 24 and 48 weeks respectively. A long-term follow-up was performed twice, initially at 24 and then at 48 months after the end of the treatment. For fingernail mycosis, the mycological cure rate was 100% at the end of month 24 and 91% at the end of month 48. Mycological cultures gave negative results in toenail infections in 90% after 24 months and in 86% after 48 months. After 24 months, 23 out of 26 patients (88%) with fingernail and 17 out of 20 patients (95%) with toenail mycosis were clinically cured. After 48 months, 20 out of 22 cases (91%) with fingernail and 10 out of 14 cases (71%) with toenail involvement showed a complete cure.

Long-term efficacy of antifungals in toenail onychomycosis: a critical review

“…Side‐effects were not mentioned in seven of the 17 studies that consisted only of follow‐up results 15–17,20 , 23–25 . Discontinuation of the treatment for side‐effects was noted in 8% of patients treated with ketoconazole 21 and in 16% of those treated with griseofulvin 22 .…”

“…We identified 15 studies in which results beyond 48 weeks were available, plus one dealing with non‐dermatophyte fungi (Table 1). 9,11 , 14–27 In addition, one study using a combination of amorolfine and terbinafine was recently published 28 …”

Onychomycosis - a kórokozók fajspektruma és terápia

“…A forgalomban levô szisztémás antimikotikumok az ergosterol képzést gátolják. A leggyakoribbnak tekintett dermatophyton fertôzés esetén a terbinafin választandó 250 mg/nap dózisban (19)(20)(21)(22). Lábköröm érintettsége esetén 3-4 hétig, kézköröm érintettség esetén 2 hónapig javasolt a kezelés folytatása.…”

Medical management of Trichophyton dermatophytosis using a novel treatment regimen in L'Hoest's monkeys (Cercopithecus lhoesti)

“…Successful treatment has also been described in other zoo animal species with a range of topical and systemic antifungals (Rotstein and others 1999, Pollock and others 2000, Hahn and others 2003). More recently, treatment with oral terbinafine has been described in human beings for dermatophyte pedal onychomycosis (Török and others 1998) and in cats with M canis ringworm infections (Mancianti and others 1999, Nuttall and others 2008). Terbinafine is a new systemic antifungal drug that has been found to be more effective in cats with generalised dermatophytosis and dermatophyte mycetoma than previous therapies and requires a shorter treatment course with once‐daily dosing (Mancianti and others 1999).…”