Long-Term Potentiation at Cerebellar Parallel Fiber–Purkinje Cell Synapses Requires Presynaptic and Postsynaptic Signaling Cascades

Wang, Dejuan; Su, Li-Da; Wang, Yanan; Yang, Dong Uk; Sun, Chengtao; Zhou, Lin; Wang, Xinxin; Shen, Ying

doi:10.1523/jneurosci.4064-13.2014

Cited by 75 publications

(98 citation statements)

References 68 publications

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“…Thus, local E2 could contribute to synaptic plasticity through pathways associated with rapid and moderate increases in calcium concentration that have been shown to be responsible for LTP in PCs (Coesmans et al 2004;Jorntell and Hansel 2006;Nilsen et al 2002;Wang et al 2014). Consistent with this idea, E2 may facilitate LTP induction as well as prevent inappropriate calcium increments that would switch the LTP into LTD (Fig.…”

Section: Possible E2 Functions On Pf Plasticity In Adult Cerebellumsupporting

confidence: 53%

Acute inhibition of estradiol synthesis impacts vestibulo-ocular reflex adaptation and cerebellar long-term potentiation in male rats

et al. 2017

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The vestibulo-ocular reflex (VOR) adaptation is an ideal model for investigating how the neurosteroid 17 beta-estradiol (E2) contributes to the modification of behavior by regulating synaptic activities. We hypothesized that E2 impacts VOR adaptation by affecting cerebellar synaptic plasticity at the parallel fiber-Purkinje cell (PF) synapse. To verify this hypothesis, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in adaptation of the VOR in male rats using an oral dose (2.5 mg/kg) of the aromatase inhibitor letrozole. We also assessed the effect of letrozole on synaptic plasticity at the PF synapse in vitro, using cerebellar slices from male rats. We found that letrozole acutely impaired both gain increases and decreases adaptation of the VOR without altering basal ocular-motor performance. Moreover, letrozole prevented long-term potentiation at the PF synapse (PF-LTP) without affecting long-term depression (PF-LTD). Thus, in male rats neurosteroid E2 has a relevant impact on VOR adaptation and affects exclusively PF-LTP. These findings suggest that E2 might regulate changes in VOR adaptation by acting locally on cerebellar and extra-cerebellar synaptic plasticity sites.

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Section: Possible E2 Functions On Pf Plasticity In Adult Cerebellumsupporting

confidence: 53%

Acute inhibition of estradiol synthesis impacts vestibulo-ocular reflex adaptation and cerebellar long-term potentiation in male rats

et al. 2017

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“…The defect in long-term depression by cPLA 2 ␣ defi ciency or COX-2 inhibition attenuates optokinetic eye movement adaptation, suggesting that cPLA 2 ␣ -regulated long-term depression is important for motor learning. Long-term potentiation is also important for motor learning and a recent report found that long-term potentiation in cerebellar parallel fi ber-Purkinje cell synapses is abolished in cPLA 2 ␣ KO mice ( 170,171 ).…”

Section: Nervous Systemmentioning

confidence: 99%

Cytosolic phospholipase A2: physiological function and role in disease

Leslie

2015

Journal of Lipid Research

350

257

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“…Thus, we may speculate that, in these individuals, non-modulated endothelial NO release and diffusion to the extracellular compartment could be detrimental for cerebellar maturation. In fact, NO is neurotoxic under conditions of excessive production [35]; in particular, abnormal NO availability impairs the regulation of granule maturation and, consequently, of the activity of Purkinje cells [36].…”

Section: Discussionmentioning

confidence: 99%

Hypnotizability and Performance on a Prism Adaptation Test

et al. 2015

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The susceptibility to hypnosis, which can be measured by scales, is not merely a cognitive trait. In fact, it is associated with a number of physiological correlates in the ordinary state of consciousness and in the absence of suggestions. The hypnotizability-related differences observed in sensorimotor integration suggested a major role of the cerebellum in the peculiar performance of healthy subjects with high scores of hypnotic susceptibility (highs). In order to provide behavioral evidence of this hypothesis, we submitted 20 highs and 21 low hypnotizable participants (lows) to the classical cerebellar Prism Adaptation Test (PAT). We found that the highs' performance was significantly less accurate and more variable than the lows' one, even though the two groups shared the same characteristics of adaptation to prismatic lenses. Although further studies are required to interpret these findings, they could account for earlier reports of hypnotizability-related differences in postural control and blink rate, as they indicate that hypnotizability influences the cerebellar control of sensorimotor integration.

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Long-Term Potentiation at Cerebellar Parallel Fiber–Purkinje Cell Synapses Requires Presynaptic and Postsynaptic Signaling Cascades

Abstract: Long-term depression (LTD) and long-term potentiation (LTP) at cerebellar parallel fiber-Purkinje cell (PF-PC

Cited by 75 publications

References 68 publications

Acute inhibition of estradiol synthesis impacts vestibulo-ocular reflex adaptation and cerebellar long-term potentiation in male rats

Acute inhibition of estradiol synthesis impacts vestibulo-ocular reflex adaptation and cerebellar long-term potentiation in male rats

Cytosolic phospholipase A2: physiological function and role in disease

Hypnotizability and Performance on a Prism Adaptation Test

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