Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

Harris, Eric W.; Ganong, Alan H.; Cotman, Carl W.

doi:10.1016/0006-8993(84)90275-0

Cited by 877 publications

(312 citation statements)

References 21 publications

Supporting

Mentioning

299

Contrasting

Order By: Relevance

“…However, the partial effect of AP5 on the Ca, transient induced by glutamate limits the interpretation of this result, even when the presence of APS-sensitive sites in hippocampus has been confirmed by several groups in cultures (Harada et al, 1992) in slice preparations (Collingridge and Singer, 1990) and in vivo (Morris et al, 1986). Moreover, it is well documented that block of these sites with AP5 does not detectably affect synaptic transmission but prevents the induction of hippocampal long-term potentiation (LTP) following brief high-frequency stimulation (Bliss and Lomo, 1973;Collingridge et al, 1983;Harris et al, 1984). It might be that Ca entry through NMDA receptor channels plays a critical role under glutamate stimulation (Lynch et al, 1983;Malenka et al, 1988).…”

Section: Specificity Of H Va I Enhancementmentioning

confidence: 99%

Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate

1994

View full text Add to dashboard Cite

The regulation of calcium channel currents (ICa) induced by daily stimulation (1 hr) with 10 microM glutamate was studied in full differentiated hippocampal cells in culture. We report a specific enhancement of the high-voltage-activated current type (HVA ICa) ongoing over days. The density of HVA ICa increased about twofold after the second glutamate session, and this enhancement was still observed after the fifth day of treatment, while low-voltage-activated calcium currents (LVA ICa) remained unchanged. During glutamate application, a transient increase of intracellular calcium (Cai) was observed, followed by a slow decay within 2–3 min, and substantial recovery in about 10 min. Similarly, Cai transients induced by periodic membrane depolarization mimicked the long-term effect of glutamate on ICa. These results demonstrate for the first time an increase of ICa in a time frame of days. Since the effect of glutamate on ICa was prevented by cycloheximide, neosynthesis of channel proteins presumably supports this enhancement.

show abstract

Section: Specificity Of H Va I Enhancementmentioning

confidence: 99%

Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate

1994

View full text Add to dashboard Cite

show abstract

“…Previously, functions of the NMDA receptor have 197 been primarily associated with long-term synaptic plasticity (Harris et al 1984;Herron et al 1986;Melchers et al 1988). In the present study it was shown that this receptor contributes, albeit modestly, to paired-pulse facilitation in the Acb.…”

Section: Paired~pulse Facilitationmentioning

confidence: 99%

“…Exceptions to this generalization, however, have been reported (Jones 1987;Nakanishi et al 1988;D'Angelo et al 1990). One of the main reasons for the recent interest in the NMDA receptor is its central role in induction of long-term potentiation, a form of synaptic plasticity that has been associated with memory formation (Harris et al 1984;Herron et al 1986;Melchers et al 1988). Behavioral experiments have shown that injection of the specific NMDA receptor antagonist D-amino-7-phosphonoheptanoic acid into the Acb impairs spatial navigation learning in rats without causing motor disturbances (Scheel-Krtiger and Willner 1991).…”

Section: Introductionmentioning

confidence: 99%

Contribution of NMDA receptors to postsynaptic potentials and paired-pulse facilitation in identified neurons of the rat nucleus accumbens in vitro

et al. 1991

View full text Add to dashboard Cite

Summary. The principal aim of this study was to characterize the transmitter mechanisms mediating fast postsynaptic potentials in identified neurons of the rat nucleus accumbens. Using the biocytin-avidin labeling technique, impaled neurons were identified as medium spiny neurons. The basic membrane characteristics of these neurons were determined. Local electrical stimulation or stimulation of the corpus callosum elicited a depolarizing postsynaptic potential consisting of an EPSP often followed by an IPSP. The quisqualate/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (4 gM) abolished most of the depolarizing postsynaptic potential. The N-methyl-D-aspartate receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid depressed a small part of the decay phase of the depolarizing postsynaptic potential. Paired-pulse facilitation of postsynaptic potentials was found using interstimulus-intervals between 10 and 150 ms. N-methyl-D-aspartate receptors were found to contribute only slightly to the facilitation of the decay phase of the depolarizing postsynaptic potential, but not to its rising phase. This contribution was particularly clear under conditions of reduced GABAA receptor mediated inhibition. The present study indicates that postsynaptic responses of medium spiny neurons in the nucleus accumbens to local stimulation or stimulation of neocortical afferents are primarily mediated by quisqualate/kainate receptors. The contribution of NMDA receptors is normally limited to a portion of the decay phase of these responses, but is enlarged in the absence of GABAergic inhibition and following paired-pulse stimulation.

show abstract

“…On the other hand, antagonists of the NMDA receptors; for example, AP5, MK-801 (dizocilpine), and phencyclidine (PCP) have been shown to block hippocampal LTP in vitro and to impair hippocampal-dependent behavior; for example, place and spatial learning (Bischoff and Tiedtke 1992;Coan et al 1987;Eichenbaum et al 1990; Morris et al 1986). These findings have led to the suggestions that NMDA receptors play a critical role in cognitive functions involving corticohippocampal circuits and that mechanisms underlying LTP and the behavioral manifestations of spatial learning are related (Collingridge et al 1988;Harris et al 1984;Morris et al 1986).…”

mentioning

confidence: 99%

A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat

Åhlander

1999

Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

Cited by 877 publications

References 21 publications

Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate

Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate

Contribution of NMDA receptors to postsynaptic potentials and paired-pulse facilitation in identified neurons of the rat nucleus accumbens in vitro

A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat

Contact Info

Product

Resources

About