Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

Douglas, Robert M.; Goddard, Graham V.

doi:10.1016/0006-8993(75)90697-6

Cited by 477 publications

(123 citation statements)

References 19 publications

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“…Thus, both the spike changes mentioned above and the EPSP changes reported here have some characteristics in common with LTE and may share ovedapping mechanisms. It is possible that the high-frequency stimulation used to induce LTE actually results in several separable types of plasticity, as has been suggested by other workers (Andersen, Sundberg, Sveen, Swann, & Wigström, 1980;Bliss & Lomo, 1973;Douglas & Goddard, 1975;Taube & Schwartzkroin, 1988;Wilson, 1981;Wilson, Levy, & Steward, 1981) and that under natural circumstances these may occur in isolation, and with very different time courses. Of course, it is also possible that other, as yet unknown, processes are responsible for these environmentally induced changes.…”

Section: Discussionmentioning

confidence: 85%

Exploration-dependent modulation of evoked responses in fascia dentata: Fundamental observations and time course

1989

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The hippocampal formation is thought to be involved in spatiallearning. A role as a more general, intermediate-term memory store has also been suggested. In this report, we address a moderately persistent change in propagation of excitation through hippocampal circuitry which resulted from exposure of animals to environments in which they were free to move and explore. Rats were prepared for chronic recording of perforant path-evoked dentate granule-cell population responses. A large increase in the synaptic component of this response developed over the first several minutes after the animals were transferred to a different but not necessarily novel environment, and decayed with a time constant of about 5 min. This apparent growth in synaptic strength was remarkably weIl correlated with the animal's recent history of exploratory behavior, and was not due simply to handling or to the electrical stimulation. The amplitude of the population-spike component also varied over time, but was not obviously correlated with changes in the synaptic component. These response changes were different in both apparent mechanism and time course from previously reported, longer lasting, environmentally induced changes in the population-spike component. They also differed from the behavioral state-dependent gating effect reported by Winson and Abzug (1977) to the extent that the present effects long outlasted the behaviors that produced them. Although further analysis is required, it is possible that this phenomenon may reflect one mode of information storage in the hippocampal formation.

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Section: Discussionmentioning

confidence: 85%

Exploration-dependent modulation of evoked responses in fascia dentata: Fundamental observations and time course

1989

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“…In the first analysis of this phenomenon, an event of 30 years ago, which is the reason for the present set of articles, Bliss & Lømo (1973) called the phenomenon long-lasting potentiation. A few years later, Douglas & Goddard (1975) proposed the name longterm potentiation, which has been generally accepted, perhaps because of its easily pronounced acronym. While both facilitation (Katz & Miledi 1968), augmentation and PTP (Magleby & Zengel 1982) are due to presynaptic increased calcium levels after the activation, LTP is probably more complex, employing a set of both pre-and postsynaptic processes each with a different time profile.…”

Section: Facilitated Synaptic Transmissionmentioning

confidence: 99%

A prelude to long-term potentiation

Andersen

2003

Phil. Trans. R. Soc. Lond. B

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“…This phenomenon came to be commonly known as long-term potentiation (LTP; Douglas and Goddard, 1975) or long-term enhancement (LTE). Early experiments suggested that LTP could be a cause of synaptic changes underlying memory formation (see Rosenzweig and Barnes, 2003 for a review).…”

Section: Introductionmentioning

confidence: 99%

The aging hippocampus: A multi-level analysis in the rat

et al. 2006

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The purpose of the current thesis was twofold: (1) to examine various factors that might be contributing to age-related learning and memory deficits specifically related to the hippocampus, and (2) to validate our rat model of aging, employing a multilevel analysis. We found age-related deficits on both spatial and non-spatial hippocampus-dependent tasks that were accompanied by structural alterations observed both in vivo (volume, but not neuronal metabolic function) and post mortem (neuronal density and neurogenesis, but not synaptic or mitochondrial density). Furthermore, our results suggest that the observed hippocampal structural changes, namely decreased volume and neurogenesis, predict learning and memory deficits, and both can be accounted for by neurogenic reduction. In addition, the above-mentioned pattern of age-related deficits closely resembles that seen in humans, suggesting the present rat version of aging to be a very useful model for investigating hippocampal aging in humans.

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Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

Cited by 477 publications

References 19 publications

Exploration-dependent modulation of evoked responses in fascia dentata: Fundamental observations and time course

Exploration-dependent modulation of evoked responses in fascia dentata: Fundamental observations and time course

A prelude to long-term potentiation

The aging hippocampus: A multi-level analysis in the rat

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